Body

Pores at the surface of neurons and muscle cells control your every thought, movement; the very beating of your heart. The way the pores behave - that is open, close, or lock for a short time (inactivate) depending on voltage - shapes signals in the form of ions moving across the cell surface.

ROCHESTER, Minn. -- For people with diabetes, taking medications and monitoring their blood sugar is part of the rhythm of their daily lives. However, according to new research from Mayo Clinic, more than 2.3 million adult patients in the U.S. are likely treated too intensively. This has caused thousands of potentially preventable emergency department visits and hospitalizations for hypoglycemia (low blood sugar).

Transgender men who become pregnant are at increased risk for depression and difficulty getting medical care due to a lack of knowledge among health care providers, a Rutgers study reports.

The study, published in the journal Maturitas, examined health care research on transgender men who become pregnant at or after age 35 to determine their medical and mental health needs.

Mothers who drink moderate to high levels of alcohol during pregnancy may be changing their babies' DNA, according to a Rutgers-led study.

LOS ANGELES — Despite numerous telephone, mail and internet scams directed toward older adults, relatives may perpetrate more financial elder abuse than strangers, suggests a new study by experts at the Keck School of Medicine of USC.

Westbury, NY - Aug. 15, 2019 - BioIVT, a leading provider of research models and services for drug and diagnostic development, today announced that researchers in its Transporter Sciences Group have co-authored a peer-reviewed DMD paper, which investigates the inhibitory effects of a class of HIV drugs known as integrase inhibitors on folate transporter pathways.1 Previously published studies had appeared to show a correlation between exposure to dolutegravir, and other HIV integrase inhibitor drugs, at conception and an increased risk of neural-tube defects (NTDs).

A drug developed by UCLA physician-scientists and chemists speeds up the regeneration of mouse and human blood stem cells after exposure to radiation. If the results can be replicated in humans, the compound could help people recover quicker from chemotherapy, radiation and bone marrow transplants.

Few people get their level of uric acid, a breakdown product of metabolism, measured in their blood. Based on Buck research published August 15 in PLOS Genetics, it might be time to rethink that, given that 20 percent of the population have elevated levels of uric acid, increasing their risk for gout, kidney stones, metabolic syndrome, obesity, diabetes and early death.

Patients with Lyme disease in England and Wales hospitals appear to be predominantly white, female and living in areas of low deprivation, according to a study published in the open access journal BMC Public Health. The study, which examined data on 2,361 hospital patients collected between 1998 and 2015, also found an increase in Lyme disease incidence over time, with the number of new cases peaking in August each year and higher rates in central southern and western England. The findings may inform and help target health promotion messages.

Having a hernia repaired, or an appendix or gallbladder removed, hurts. And for the past two decades, patients having these common operations in the U.S. have gone home from the hospital with prescriptions for dozens of opioid pills to ease that pain.

But with rising concern about the role of those pills in the national opioid epidemic, a new study shows how one state's surgeons reduced the number of opioids they prescribed to thousands of patients -- without causing patients to feel more pain or less satisfied with their surgical experience.

Immunotherapeutic drugs are a potent way of transforming the immune system into a ferocious guard dog that can sniff out and destroy tumor cells. But for some therapies, it helps to have a leash. Without one, immunotherapies can do their job too well, stimulating the immune system to overreact, causing systemic toxicity.

WHAT:

The All of Us Research Program at the National Institutes of Health has made strong progress in its efforts to advance precision medicine, according to program leadership in a forthcoming paper in the New England Journal of Medicine.

A phase 1 clinical trial has demonstrated that a two-step gene therapy treatment was safe and effective in 31 patients with recurrent glioblastoma - a stubborn form of brain cancer - potentially overcoming a major hurdle that has hindered the use of systemically administered interleukin 12 (IL-12)-based regimens. The therapy boosted the infiltration of immune cells into tumors and showed encouraging preliminary benefits, indicating it has promise as a treatment for patients with this usually fatal disease.

An international team of researchers led by scientists at Washington University School of Medicine in St. Louis has identified a pair of genes that influence risk for both late-onset and early-onset Alzheimer's disease.