Although largely paralyzed, ALS patients can communicate through eye-tracking devices because they retain eye movement until the disease's late stages. Yet, how some motor neurons resist ALS to allow for this movement has been a mystery.
Now, scientists have developed a stem-cell-based modeling system that identifies how some neurons are resistant to ALS--a breakthrough that offers potential for battling neurodegeneration.
Altered blood flow resulting from heart injury switches on a communication cascade that reprograms heart cells and leads to heart regeneration in zebrafish, says a new study in eLife.
The findings reveal signalling pathways important for heart regeneration in zebrafish that are also present in mammals, providing insights that could help scientists find new ways to repair the organ after a heart attack in future.
Glioblastomas, the deadliest type of brain tumor in adults, attract "turncoats." These are macrophages, a type of immune cell, which promote tumor progression and mask tumors from the immune system's scrutiny. To better understand the cells that brain tumors recruit, scientists led by Dolores Hambardzumyan, PhD, developed advanced imaging techniques to visualize macrophages found in the brain tumors of living mice.
The results were published Monday, June 24 in PNAS.
Tuesday, June 25, 2019, Cleveland: Implemented back in 2005, the lung allocation score is used to prioritize patients awaiting lung transplants in the United States. Sicker transplant candidates have a higher calculated score and are placed at the top of the list. But a recent study led by Maryam Valapour, M.D., MPP, director of Lung Transplant Outcomes in Cleveland Clinic's Respiratory Institute, found including new clinical variables helped to better identify the sickest cystic fibrosis and chronic obstructive pulmonary disease (COPD) patients awaiting transplants.
A biological pathway previously found to contribute to the impact of stress on the risk of cardiovascular disease also may underlie the increased incidence of such disease experienced by individuals with lower socioeconomic status.
As a sugar substitute, zero-calorie sweeteners may reduce tooth decay and blood sugar spikes. Seven are approved worldwide and safe for humans - but does this mean they're healthy?
For the first time, scientists exposed pregnant and lactating mice to sucralose and acesulfame-K - a common combination in soda, sports supplements and other sweetened products - and found their pups developed harmful metabolic and gut bacteria changes.
They have been called the 'time bomb' of cardiology - ascending aortic aneurysms grow for decades without any warning signs and can be fatal once they rupture. They have taken the lives of well-known actors Alan Thicke and John Ritter and are a leading cause of death in North America.
In a new study published in EBioMedicine, researchers at Western University and Lawson Health Research Institute demonstrate what might be causing these aneurysms and potentially how to treat them.
ANAHEIM, CA (Embargoed until 9 a.m. PDT, Tuesday, June 25, 2019) - Acute kidney injury (AKI) often complicates the treatment outcomes of hospitalized patients, resulting in dangerous levels of toxic chemicals accumulating in the blood and causing numerous deaths annually. Currently, only supportive treatment is available for AKI, but two related research studies presented at the 2019 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging offer hope for effective treatment and prevention.
ANAHEIM, CA (Embargoed until 9 a.m. PDT, Tuesday, June 25, 2019) - A novel therapy using two targeted treatments for prostate cancer has been shown to maximize efficacy while reducing side effects according to research presented at the Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2019 Annual Meeting.
Columbia researchers have created a way to grow human hair in a dish, which could open up hair restoration surgery to more people, including women, and improve the way pharmaceutical companies search for new hair growth drugs.
It is the first time that human hair follicles have been entirely generated in a dish, without the need for implantation into skin.
Using 3D-Printing to Stop Hair Loss
For years it's been possible to grow mouse or rat hairs in the lab by culturing cells taken from the base of existing follicles.
Research into the hearts of zebrafish, a pet shop staple marked by their eponymous stripes, has shed light on ways the human heart muscle could be healed following damage.
A team of researchers led by Neil Chi, MD, PhD, professor of medicine at University of California San Diego School of Medicine, and Manuel Galvez-Santisteban, PhD, a postdoctoral scientist working alongside him, have pinpointed a signaling pathway in zebrafish heart cells that leads to the regeneration of damaged tissue. The findings are published in the June 25, 2019 issue of eLife.
A 10 per cent tax on sugary drinks has cut the purchase and consumption of sugary drinks by an average of 10 per cent in places it has been introduced, a just published major review has found.
WASHINGTON--Women exposed to triclosan are more likely to develop osteoporosis, according to a study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.
A new study soon to appear in the Journal of Public Health suggests that air pollution and living in apartment buildings may be associated with an increased risk for dangerous conditions like heart disease, stroke, and type 2 diabetes.
Vienna, 25 June 2019: The adverse effect of maternal smoking during pregnancy is well established and associated with several negative neonatal outcomes (such as low birth weight and preterm birth). It is also evident in some studies that the semen quality of men exposed to prenatal maternal smoking is generally more impaired than that of unexposed men.(1) However, there is little known about the effect of paternal smoking in the time leading up to and during pregnancy.