Body

A small drug molecule that appears to protect normal tissue from the damaging effects of radiation, may simultaneously be able to boost the cancer-killing effect of radiation therapy, according to a new study led by scientists at University of Iowa, University of Texas Southwestern Medical Center, and Galera Therapeutics, Inc.

Irvine, CA - May 13, 2021 - A new University of California, Irvine-led study finds low serum levels of the sugar N-acetylglucosamine (GlcNAc), is associated with progressive disability and neurodegeneration in multiple sclerosis (MS).

The study, done in collaboration with researchers from Charité - Universitätsmedizin Berlin, Germany, and the University of Toronto, Canada, is titled, "Association of a Marker of N-Acetylglucosamine With Progressive Multiple Sclerosis and Neurodegeneration," The study was published this week in JAMA Neurology.

Laura Riesenberg was visiting a local amusement park with three of her children when she suffered a massive heart attack.

"I was down for about 20 minutes and they defibrillated me twice on site, possibly three times," she says. "Obviously, I was unaware of it. I know from reading the reports what happened."

"I was extremely fortunate that someone found me within seconds of collapsing," says Riesenberg. "Had it happened anywhere else I wouldn't be talking to you right now. If I had been in the basement doing laundry, I would have been in trouble."

A large-scale randomised trial of annual screening for ovarian cancer, led by UCL researchers, did not succeed in reducing deaths from the disease, despite one of the screening methods tested detecting cancers earlier.

Results from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) have been published in a report in the medical journal The Lancet.

BOSTON - B cells are the immune cells responsible for creating antibodies, and most B cells, known as B2 cells, produce antibodies in response to a pathogen or a vaccine, providing defense and immunity against infections. But a small subset of long-lived B cells, known as B1 cells, are quite different from their short-lived cousins, the B2 cells. Instead of producing antibodies in response to invaders, they spontaneously make antibodies that perform vital housekeeping functions, such as removing waste like oxidized LDL cholesterol from the blood.

Bethesda, MD (May 14, 2021) -- Daily probiotic use was associated with fewer upper respiratory symptoms in overweight and older people, according to a study that suggests a potential role for probiotics in preventing respiratory infections. The study was selected for presentation at Digestive Disease Week® (DDW) 2021.

Monash University researchers have validated a way to successfully detect a diverse range of bacteria (pathogens) that cause diarrhoeal disease in informal settlements.

Better protection from disease for people living in communities facing water, sanitation and hygiene challenges is essential, as microbes that cause gastrointestinal disease (enteropathogens) are responsible for 1.4 million deaths per year, predominantly in children under five, and cause impaired nutrition and development.

Two-thirds of California prisoners who were offered a COVID-19 vaccine accepted at least one dose, according to a new study by researchers at the Stanford University School of Medicine.

"We found that many incarcerated people in California prisons were willing to be vaccinated for COVID-19," said Elizabeth Chin, the lead author of the study and a PhD candidate in biomedical data science. "This is an encouraging sign for other states at an early stage of rolling out vaccination programs in their prisons and jails."

LA JOLLA, CA--Scientists at Scripps Research have unveiled a new Ebola virus vaccine design, which they say has several advantages over standard vaccine approaches for Ebola and related viruses that continue to threaten global health.

Environmental enrichment -- with infrastructure, unfamiliar odors and tastes, and toys and puzzles -- is often used in zoos, laboratories, and farms to stimulate animals and increase their wellbeing. Stimulating environments are better for mental health and cognition because they boost the growth and function of neurons and their connections, the glia cells that support and feed neurons, and blood vessels within the brain. But what are the deeper molecular mechanisms that first set in motion these large changes in neurophysiology?

Researchers used genetic engineering tools to create a virus that can enter specific neurons and insert into the prefrontal cortex a new genetic code that induces the production of modified proteins. In tests with mice, the alteration of these proteins was sufficient to modify brain activity, indicating a potential biomarker for the diagnosis of psychiatric disorders such as schizophrenia and autism.

UCLA life scientists have identified six "words" that specific immune cells use to call up immune defense genes -- an important step toward understanding the language the body uses to marshal responses to threats.

The immune system's main job is identifying things that can make us sick. In the language of immunology, this means distinguishing "self" from "non-self": The cells of our organs are self, while disease-causing bacteria and viruses are non-self.

But what about the billions of bacteria that live in our guts and provide us with benefits like digesting food and making vitamins? Are they friend or foe?

Our body's relationship with bacteria is complex. While infectious bacteria can cause illness, our gut is also teaming with "good" bacteria that aids nutrition and helps keep us healthy. But even the "good" can have bad effects if these bacteria end up in tissues and organs where they're not supposed to be.

The quest to create safer, more successful pregnancies is one of the top goals of modern science. While pregnancy is better understood today than ever before, with improvements in technology helping to lower the risk of negative outcomes, there is much researchers still don't know about a vital part of the pregnancy process: uterine fluid.