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In patients presenting to an emergency department with severe traumatic pain, intranasal sufentanil was as good as standard-of-care intravenous morphine for pain relief, according to a new study published this week in PLOS Medicine by Marc Blancher of Grenoble Alpes University Hospital, France, and colleagues.

Initiating stroke treatment just 15 minutes faster can save lives and prevent disability, according to a new UCLA-led study, published today in JAMA.

First-ever study to ask people who use heroin what they want to be called finds "people first" language often best, and language suggesting misuse or dependence generally worst.

They are added to a large number of foods to perform various technological functions, e.g. as acidity regulators. These include soft drinks, especially cola beverages, whipped cream and cream products, milk drinks, milk powder and coffee whitener, as well as meat products.

This indicator should give information on total intake of plant protection product residues from food. The three categories of low, moderate and high intake to which the active substances in the plant protection products can then be allocated are essential here. "Consumer safety is strengthened by these valuable indicators for risk identification," says BfR President Professor Dr. Dr. Andreas Hensel. "Politics benefits from this too, because it is then easier to take specific measures to protect the population".

Carbofuran is a plant protection product which can be used against certain insects, mites, ticks and nematodes. On the basis of the amount of the carbofuran residues and estimated dietary intake of red chilies, an exceedance of the acute reference dose (ARfD) is not to be expected for children or adults. The ARfD describes the quantity of a substance per kilogram of body weight that consumers can ingest with their food in one meal or in several meals spread over one day without any recognisable effect on health.

One type is micro-RNA (miRNA), and its job is to regulate numerous processes in a cell. It has been suggested, however, that some of these miRNAs are involved in the emergence of tumours and other health problems.

According to the Centers for Disease Control and Prevention, opioid overdoses were responsible for more than 42,000 deaths in 2016. Access to family members' drugs may be a strong risk factor for overdose in individuals without their own prescriptions, according to a new study by investigators from Brigham and Women's Hospital. Their findings were published recently in JAMA Internal Medicine.

A molecular "trick" that kept our ancient ancestors from starving may now be contributing to the obesity epidemic, a new study finds.

In starvation times, researchers say, animals were more likely to survive if they could hoard and stretch out their stored energy. Even if an animal secured a rare feast, evolution smiled on the storage of excess fuel as fat, given the likelihood of a quick return to starvation.

PITTSBURGH, July 16, 2019 - Death rates from sepsis fell faster in New York than expected--and faster than in peer states--following the introduction of the nation's first state-mandated sepsis regulation, according to an analysis led by University of Pittsburgh researchers and published today in JAMA.

Bottom Line: A randomized clinical trial involving patients, family members and clinicians from 36 adult intensive care units in Brazil looked at whether flexible family visitation (up to 12 hours per day) plus family education on ICUs and delirium would reduce the occurrence of delirium compared to standard visitation of up to 4½ hours per day. The study included 1,685 patients. The authors report no significant difference in reducing the occurrence of delirium between flexible and standard visitation. Limitations of the study include that it was restricted to a single country.

What The Study Did: Hospital discharge data was used to examine the association between New York state sepsis regulations and the outcomes of patients hospitalized with sepsis.

Authors: Jeremy M. Kahn, M.D., M.S., of the University of Pittsburgh, is the corresponding author.

(doi:10.1001/jama.2019.9021)

Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Lung cancer patients who had a hurricane disaster declared during radiotherapy had worse overall survival than those who completed treatment in normal circumstances, with longer disaster declarations associated with increasingly worse survival. The finding comes from a report by American Cancer Society investigators published in JAMA, which suggests several mitigation strategies, including arranging for transferring treatment and eliminating patient out-of-network insurance charges during disasters.

Removing the barriers of access to technology does not close the digital divide for African American and older patients, according to new research from The Ohio State University College of Medicine.

BOSTON (July 16, 2019)-- A new study published in Cell Reports found that a transcription factor called Slug serves as 'command central' for determining breast stem cell health, regulating both stem cell activity and repair of DNA damage. The research team also discovered that Slug likely functions as a safeguard against age-related decline of breast stem cell function.