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Glenview, Illinois - The American College of Chest Physicians® (CHEST) announced the publication of updates to the evidence-based guidelines on therapy for pulmonary arterial hypertension (PAH). PAH is a progressive disease that affects the small arteries in the lungs, which can lead to right-sided heart failure and death. There is no cure for PAH; there are several medications approved for the treatment of the disease.

CRISPR is a technique that is revolutionizing biomedical research through high-precision genome editing. However, even though it allows the creation or correction of mutations consisting of a single or few nucleotides with relative ease, it still possesses limitations upon introducing larger fragments of DNA in the genome. For instance, the genomic insertion of a gene that produces a fluorescent protein such as the widely-used GFP suffers from poor efficiency and involves complicated cloning steps.

HONOLULU, Feb. 6, 2019 -- Intravenous (IV) insulin did not improve stroke outcomes compared to standard blood sugar (glucose) control using insulin shots - answering a worldwide debate about the best way to control glucose in stroke patients. These primary late-breaking findings were presented at the American Stroke Association's International Stroke Conference 2019, a world premier meeting for researchers and clinicians dedicated to the science and treatment of cerebrovascular disease.

HONOLULU, Feb. 6, 2019 -- Lowering blood pressure in the ambulance with a nitroglycerin patch for suspected stroke didn't lessen post-stroke disability, according to late breaking science presented at the American Stroke Association's International Stroke Conference 2019, a world premier meeting for researchers and clinicians dedicated to the science and treatment of cerebrovascular disease.

HONOLULU, Feb. 6, 2019 -- Stroke survivors taking a combination of the blood thinner cilostazol with aspirin or clopidogrel had a lower risk of ischemic stroke recurrence than those who received aspirin or clopidogrel alone, according to late breaking science presented at the American Stroke Association's International Stroke Conference 2019, a world premier meeting for researchers and clinicians dedicated to the science and treatment of cerebrovascular disease.

Researchers at the University of Waterloo have developed a new way to prevent and treat Chlamydia, the most common sexually transmitted bacterial infection in the world.

The new treatment differs from the traditional anti-biotic treatment as it is a type of gene therapy that is delivered via nanotechnology and is showing a 65 per cent success rate in preventing chlamydia infection on a single dose.

MYC, a gene with high cancer-initiating potential, is overexpressed in over 40% of breast cancers. While MYC programs breast cancer cells to build more macromolecules (anabolic metabolism) it also creates a metabolic vulnerability by making them more sensitive to a type of cell death known as apoptosis. Research Director Juha Klefstrom, PhD, University of Helsinki, Finland, has worked for a long time to exploit this apoptosis-sensitizing effect of MYC in the battle against the cancer.

CHAPEL HILL, NC - Results from a study published in the journal Cancer Medicine show that a pragmatic system-based intervention within cancer treatment centers can eliminate existing disparities in treatment and outcomes for black patients with early-stage lung cancer across the U.S. The treatment rates before this three-part intervention were 78 percent for white patients versus 69 percent for black patients. With the intervention in place, treatment rates climbed to 95 percent for white patients and 96.5 percent for black patients.

Highlight

Certain practices in dialysis facilities related to managing fluid volume and low blood pressure during dialysis are important to patients' health and survival.

Washington, DC (February 5, 2019) -- A new study highlights the importance of regular and careful assessment of dry or target weight and fluid balance in patients undergoing hemodialysis. The study appears in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN).