Body

The cover for issue 65 of Oncotarget features Figure 7, "EGFR activated cases compared to pathway markers," by Kucherlapati, et al.

Molecular subtypes based on copy number, DNA methylation, and mRNA expression had variable proliferation levels, the highest correlating with decreased survival.

BLOOMINGTON, Ind. -- Romantic partners aren't always honest about money in their relationships, but when does hiding purchases, debt and savings constitute "financial infidelity"? Research by professors at four universities, including Indiana University, defines the concept and provides a means for predicting its occurrence within relationships.

"Love, Lies and Money: Financial Infidelity in Romantic Relationships," forthcoming in the Journal of Consumer Research, is the first systematic investigation of financial infidelity in committed romantic relationships.

Efforts to prevent new HIV transmissions in the United States must be accompanied by advances in addressing HIV-associated comorbidities to improve the health of people already living with HIV, National Institutes of Health experts assert in the third of a series of JAMA commentaries.

Emphasis on particular groups hinders efforts to address the problem of declining physical activity in children, according to a study led at the University of Strathclyde.

A review of more than 50 published studies, covering a total of 22,000 children, found that children of all ages around the world are at risk from a decline in physical activity. It fell steadily from the age of four or five, in both boys and girls and in every part of the world covered by the study.

DES PLAINES, IL -- Video discharge instructions in the emergency department are associated with less perceived acute otitis media (AOM) symptomatology compared to a paper handout. That is the finding of a study published in the December 2019 issue of Academic Emergency Medicine (AEM), a journal of the Society for Academic Emergency Medicine (SAEM).

Neuroblastoma can grow and spread in the body very aggressively, making it very difficult to treat. New research has shed important light on the factors at play in the metastasis of neuroblastoma, which could potentially lead to new treatment strategies.

The findings, recently published in the British Journal of Cancer, were discovered by Professor Maria Kavallaris and her team, through scientific research funded by The Kids Cancer Project.

The aggressive nature of neuroblastoma

Boston, MA -- Psoriasis is a skin disorder that affects at least 100 million individuals worldwide. Its economic impact is more than $10 billion annually in the U.S. alone. Involved skin becomes thickened, red, and covered with silvery scales, while changes to the nails and deforming inflammation of the joints may also occur in up to one-third of affected individuals. The underlying cause of psoriasis remains a mystery, and effective targeted therapies remain to be developed.

ATLANTA--Targeted immunization against bacterial flagellin, a protein that forms the appendage that enables bacterial mobility, can beneficially alter the intestinal microbiota, decreasing the bacteria's ability to cause inflammation and thus protecting against an array of chronic inflammatory diseases, according to a new study by the Institute for Biomedical Sciences and the Neuroscience Institute at Georgia State University.

DALLAS, Dec. 11, 2019 -- Low-dose aspirin was not associated with a reduced risk of a fatal heart attack among African Americans, according to an observational study published in the Journal of the American Heart Association, the open access journal of the American Heart Association.

December 11, 2019 -- Results of a new study suggest that over the past decade (2005-2017), the prevalence of cannabis use in the United States has increased among persons with and without depression, though the increase is significantly more rapid among those with depression. At the same time, the perception of risks associated with cannabis use have declined overall, and the decline has been more rapid among those with depression. The findings, which are published in Addiction, come from a survey-based study of 728,691 persons aged 12 years or older.

SAN ANTONIO -- Researchers from The University of Texas MD Anderson Cancer Center today reported study results showing the addition of tucatinib to capecitabine (Xeloda) and trastuzumab (Herceptin) significantly improved progression-free survival (PFS) and overall survival (OS) in patients with advanced HER2-positive breast cancer, with and without brain metastasis according to results of the HER2CLIMB clinical trial.

SPOKANE, Wash. - A new study conducted by researchers at Washington State University shows that individuals with chronic sleep-onset insomnia who pulled an all-nighter performed up to twice as bad on a reaction time task as healthy normal sleepers. Their findings were published today in the online journal Nature and Science of Sleep.

The tropical disease Leishmaniasis is being tackled by catching female sand flies who carry the parasite that causes the disease.

Scientists led by Professors Orin Courtenay of Warwick University and Gordon Hamilton of Lancaster University, developed the concept as part of a £2.5M project funded by The Wellcome Trust and published in PLOS Neglected Tropical Diseases.

There are now plans to commercialise the research which involves using male pheromones to attract female sand flies towards insecticide-treated areas.

Edith Cowan University researchers have found that a chronic disease affecting up to 80 per cent of overweight people may be causing an iron deficiency that simply leaves them too tired to get off the couch.

Fatty liver disease affects about one in three Australians and is often associated with being overweight or obese. If left untreated, it can lead to liver cirrhosis, liver cancer and increase the risk of a heart attack.

But the remedy - to lose weight through diet or exercise - is often difficult to achieve for affected individuals.