Body

MINNEAPOLIS/ST.PAUL (05/12/2021) -- In a study recently published in Nature, University of Minnesota Medical School researchers found that senescent immune cells are the most dangerous type of senescent cell.

Cells become senescent when they are damaged or stressed in the body, and they accumulate in our organs as we age. Senescent cells drive inflammation and aging as well as most age-related diseases.

A portable, rapid testing platform can detect gonorrhea infections in patient samples in under 15 minutes, far faster than standard-of-care tests that can take hours or days. The platform accurately detected infections and determined resistance to a common antibiotic in 217 patient samples from sexual health clinics in Baltimore and Uganda. The technology's speed and low cost could empower quicker and more affordable gonorrhea testing in low-resource regions, as well as help combat the spread of drug-resistant strains.

DALLAS, May 13, 2021 -- Higher body mass index (BMI) in adolescence is associated with a significantly higher risk of first ischemic stroke in adults under age 50 regardless of whether they had Type 2 diabetes, according to new research published today in Stroke, a journal of the American Stroke Association, a division of the American Heart Association.

While rates of adolescent obesity and stroke among adults under the age of 50 years continue to rise around the world, the precise link between the two conditions is still not fully understood.

COLUMBUS, Ohio - A new study's findings dispel the misconception that patients and providers are at high risk of catching COVID-19 at the dentist's office.

SARS-CoV-2 spreads mainly through respiratory droplets, and dental procedures are known to produce an abundance of aerosols - leading to fears that flying saliva during a cleaning or a restorative procedure could make the dentist's chair a high-transmission location.

Philadelphia, May 12, 2021 - Researchers at the Center for Applies Genomics (CAG) at Children's Hospital of Philadelphia (CHOP) have revealed how variants of a gene responsible for packing and condensing genetic material present a novel cause for certain neurodevelopmental disorders. The findings were published today in Science Advances.

Stanford scientists' software turns 'mental handwriting' into on-screen words, sentences

Call it "mindwriting."

The combination of mental effort and state-of-the-art technology have allowed a man with immobilized limbs to communicate by text at speeds rivaling those achieved by his able-bodied peers texting on a smartphone.

What The Study Did: This survey study estimated the number of children and adolescents in the United States who have received medical care as a result of assault, abuse or exposure to violence.

Authors: David Finkelhor, Ph.D., of the University of New Hampshire in Durham, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2021.9250)

LA JOLLA, CALIF. - May 12, 2021 - Scientists at Sanford Burnham Prebys Medical Discovery Institute have taken a deep dive into a previously overlooked family of proteins and discovered that they are essential to maintaining the energy that cells need to grow and survive. The proteins, known as lipid kinases, produce messengers that help balance cellular metabolism and promote overall health. The findings, published in Developmental Cell, provide further support to pursue lipid kinases as promising therapeutic targets for diseases that demand excess energy, such as cancer.

PHILADELPHIA--A low-cost, rapid diagnostic test for COVID-19 developed by Penn Medicine provides COVID-19 results within four minutes with 90 percent accuracy. A paper published this week in Matter details the fast and inexpensive diagnostic test, called RAPID 1.0 (Real-time Accurate Portable Impedimetric Detection prototype 1.0).

Researchers from the £12 million Developing Human Connectome Project have used the dramatic advances in medical imaging the project has provided to visualise and study white matter pathways, the wiring that connects developing brain networks, in the human brain as it develops in the womb.

Researchers at the Francis Crick Institute and the Latvian Institute of Organic Synthesis have designed a drug-like compound which effectively blocks a critical step in the malaria parasite life cycle and are working to develop this compound into a potential first of its kind malaria treatment.

Multiple sclerosis, or MS for short, manifests itself slightly differently in each person - which is why some call it "the disease of a thousand faces." Arguably the worst manifestation of MS is its chronic progressive form. Unlike the more common relapsing-remitting variant (RRMS), in which sufferers are often symptom-free for months or even years, patients with the primary progressive form of the disease (PPMS) see their condition steadily deteriorate with no remissions.

Poorly insulated neurons die off

Modern vaccines such as those against Sars-CoV-2 use tiny lipid spheres to transport genetic information into cells and let the body build up an immune defense against the virus. A team of scientists from Erlangen, Dresden, and London has now developed a completely new method to very efficiently deliver not only genes but also drugs and other substances into cells.

Acta Pharmaceutica Sinica B Volume 11, Issue 4 Publishes

https://www.sciencedirect.com/journal/acta-pharmaceutica-sinica-b/vol/11/issue/4

Special Issue: The Biological Fate of Drug Nanocarriers

This special issue includes seven review and nine research articles from some leading scientists in the field that further the discussion on subtopics of in vivo fate of drug nanocarriers.

Meat that is certified organic by the U.S. Department of Agriculture is less likely to be contaminated with bacteria that can sicken people, including dangerous, multidrug-resistant organisms, compared to conventionally produced meat, according to a study from researchers at the Johns Hopkins Bloomberg School of Public Health.