Body

Research led by Dr. Wonmuk Hwang has led to better understanding on how components of the body's immune system find intruding or damaged cells, which could lead to novel approaches to viral and cancer treatments.

Hwang, associate professor in the Department of Biomedical Engineering at Texas A&M University, has written about this in an article recently published in the journal Proceedings of the National Academy of Sciences.

LA JOLLA, CA--Ever since SARS-CoV-2 first appeared, researchers have been trying to understand whether sometimes the immune system does more harm than good during the acute phase of COVID-19. The latest study by researchers at La Jolla Institute for Immunology clearly argues in favor of the immune system.

Out of any other racial group, African American men have the lowest five-year survival rate for colorectal cancer (CRC). A major factor contributing to this dire situation is low adherence to recommended early detection screening, like colonoscopy and home-based stool testing kits. Yet, published research on effective strategies to increase screening for this group specifically are minimal. These findings were published today in a special health inequities and disparities issue of the journal PLOS ONE.

New Rochelle, NY, September 16, 2020—Intracranial abnormalities on CT scan in patients with traumatic brain injury (TBI) can be predicted by glial fibrillary acidic protein (GFAP) levels in the blood. These interim findings from the TRACK-TBI study are published in the peer-reviewed Journal of Neurotrauma. Click here to read the article now.

Leesburg, VA, September 16, 2020--According to ARRS' American Journal of Roentgenology (AJR), ultrasound-guided carpal tunnel release (UGCTR) quickly improves hand function and reduces hand discomfort, making UGCTR a safe, effective, and less invasive alternative to traditional open or endoscopic surgery.

The cover for issue 37 of Oncotarget features Figure 7, "The combination of romidepsin and KU60019 is synergistic in a xenograft model of MCL," by Scotto, et al. which reported that the antiproliferative effect induced by histone deactylase inhibitors is associated with the up-regulated expression of the cyclin-dependent kinase inhibitor p21. Paradoxically, the increased expression of p21 correlates with a reduced cell killing to the drug.

DALLAS, Sept. 16, 2020 -- Heart transplant patients who received hearts from severely obese donors had similar short-term outcomes and long-term survival as patients who received hearts from non-obese donors, according to new research published today in Circulation: Heart Failure, an American Heart Association journal.

DALLAS, Sept. 16, 2020 -- Better heart health, as measured by the American Heart Association's Life's Simple 7 (LS7) scale, was associated with a significantly lower risk of developing high blood pressure (also known as hypertension) in middle-aged, Black and white adults, according to new research published today in the Journal of the American Heart Association, an open access journal of the American Heart Association.

Hennigsdorf/ Berlin, Germany, September 16, 2020 - 4TEEN4 Pharmaceuticals GmbH ("4TEEN4") announces data on the efficacy of its lead product, Procizumab, that promptly restored cardiac dysfunction in a preclinical sepsis model by inhibiting the cardiac depressant factor DPP3. The current findings indicate that DPP3 plays an important role in septic cardiomyopathy. Sepsis is a dysregulated host response to an infection that ultimately leads to organ dysfunction.

Initial findings reported by the Arizona COVID-19 Genomics Union (ACGU) suggest that following Arizona's first reported case of COVID-19 in late January, the state experienced no subsequent cases that went undetected and was COVID-free until at least 11 distinct incursions occurred between mid-February and early April.

The published results appear in the scientific journal mBio.

For many people who are struggling to conceive, in-vitro fertilization (IVF) can offer a life-changing solution. But the average success rate for IVF is only about 30 percent. Investigators from Brigham and Women's Hospital and Massachusetts General Hospital are developing an artificial intelligence system with the goal of improving IVF success by helping embryologists objectively select embryos most likely to result in a healthy birth.

The ASF pathogen is a virus which infects domestic pigs and wild boar and which leads to a severe, often lethal, disease in these animals. It is transferred via direct contact or with excretions from infected animals, or through ticks. The ASF virus is endemic to infected wild animals in Africa, but there have also repeatedly been outbreaks in southern Europe. The pathogen has been spreading north-westwards since 2007 from Georgia through Armenia, Azerbaijan and Russia. Cases of ASF have been registered in wild boar along with outbreaks in domestic pigs in the Baltic states since 2014.

Cell therapy for cardiac regeneration, while promising, has been hampered by issues with long-term survival of the transplanted cells. Now, a technique that combines three different types of cells in a 3D cluster could improve its efficacy in reducing scar tissue and improving cardiac function after a heart attack.

The SARS-CoV-2 pandemic has put the use of personal protective equipment (PPE), including face masks, under the global spotlight. However a paper published in Anaesthesia (a journal of the Association of Anaesthetists) reveals that masks do not always fit correctly and hospitals can lack the time and financial resources to ensure every healthcare worker has a mask that fits correctly.

Increasingly, everyday activities and services are shifting online, making the ability to use the internet an essential skill. The current COVID-19 pandemic has further highlighted the importance of digital connectivity, especially for older and vulnerable adults, for their continued contact with family and friends. Digital Ambassadors, a Singapore Government initiative to ensure all Singaporeans have access to the fundamental digital tools, helps older adults learn how to use technological tools.