Researchers at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, have retrieved nuclear genome sequences from the femur of a male Neandertal discovered in 1937 in Hohlenstein-Stadel Cave, Germany, and from the maxillary bone of a Neandertal girl found in 1993 in Scladina Cave, Belgium. Both Neandertals lived around 120,000 years ago, and therefore predate most of the Neandertals whose genomes have been sequenced to date.
ANN ARBOR, Michigan -- The Fast and the Furious movie franchise meets the Fast N' Loud television series to define an oncogene that drives 35% of prostate cancers.
A new study from researchers at the University of Michigan Rogel Cancer Center finds that the gene FOXA1 overrides normal biology in three different ways to drive prostate cancer. They refer to the three classes as FAST, FURIOUS, and LOUD to reflect their unique features. The findings are published in Nature.
A study of pediatric patients with leukemia demonstrates that they were able to generate T cells against tumor-associated mutations, contradicting previous assumptions that T cells cannot be effectively unleashed on pediatric tumors. Importantly, the findings indicate that pediatric cancers may be more vulnerable to immunotherapies such as checkpoint blockade and other T cell-targeted treatments than previously thought. Tumors often express mutant surface proteins (or neoepitopes) not found in normal cells, which can be recognized and targeted by T cells.
The Himalayan orogenic belt produces frequent large earthquakes that impact population centers for a distance of over 2500 km. In the central region, the 2015 Gorkha earthquake in Nepal, with moment magnitude (MW) 7.8, partially ruptured a ~120-km by 80-km patch of the Main Himalayan Thrust (MHT), the detachment that separates the underthrusting Indian plate from the overriding Himalayan orogeny.
Entanglement is one of the main principles of quantum mechanics. Physicists from Professor Johannes Fink's research group at the Institute of Science and Technology Austria (IST Austria) have found a way to use a mechanical oscillator to produce entangled radiation. This method, which the authors published in the current edition of Nature, might prove extremely useful when it comes to connecting quantum computers.
For the first time, researchers have decoded the genetic programmes that control the development of major organs in humans and other selected mammals - rhesus monkeys, mice, rats, rabbits, and opossums - before and after birth. Using next-generation sequencing technologies, the molecular biologists at Heidelberg University analysed the brain, heart, liver, kidney, testicles, and ovaries.
A Frog Worth Kissing: Natural Defense Against Red Tide Toxin Found in Bullfrogs
By ALIYAH KOVNER
A team led by Berkeley Lab faculty biochemist Daniel Minor has discovered how a protein produced by bullfrogs binds to and inhibits the action of saxitoxin, the deadly neurotoxin made by cyanobacteria and dinoflagellates that causes paralytic shellfish poisoning.
In a study published online in Nature on June 26, research teams led by Dr. YANG Weiwei at the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences (CAS) and Dr. LI Guohui from the Dalian Institute of Chemical Physics of CAS reported a new function of uridine diphosphate glucose (UDP-glucose), a metabolic intermediate in the uronic acid pathway: It impairs lung cancer metastasis by accelerating SNAI1 mRNA decay.
Electronic properties of materials can be directly influenced via light absorption in under a femtosecond (10-15 seconds), which is regarded as the limit of the maximum achievable speed of electronic circuits. In contrast, the magnetic moment of matter has only been able to be influenced up to now by a light and magnetism-linked process and roundabout way by means of magnetic fields, which is why magnetic switching takes that much longer and at least several hundred femtoseconds.
Although the exact causes of multiple sclerosis still remain unknown, it is assumed that the disease is triggered by a combination of genetic and environmental risk factors. But which? In a mouse model of the disease, researchers at the University of Geneva (UNIGE) and the Geneva University Hospitals (HUG) , Switzerland, studied the potential link between transient cerebral viral infections in early childhood and the development of this cerebral autoimmune disease later in life.