Body

New research published this week in JAMA Oncology has found a lack of racial and ethnic diversity in clinical trials for cancer drugs.

The study--conducted by researchers from UBC, the University of Texas MD Anderson Cancer Center, the Fred Hutchinson Cancer Center in Seattle and Baylor University in Texas--raises concerns about the effectiveness of cancer drugs in some patients, especially since genetic differences may affect how well a patient responds to a drug.

Using questionnaire answers from thousands of internal medicine residents, primarily from U.S. training programs, a research team at Johns Hopkins Medicine says it has added to the evidence that bullying of medical trainees is fairly widespread. Bullying affects about 14% of medical trainees overall, but is particularly more prevalent among foreign-born trainees.

BOSTON - In a first-of-its kind study, neurologists at Beth Israel Deaconess Medical Center (BIDMC) tested the use of non-invasive electrical stimulation as a novel therapeutic approach to brain tumors.

BOSTON - Researchers at Massachusetts General Hospital (MGH) have taken a key step forward in developing a new, possibly safer contrast agent for use in magnetic resonance imaging (MRI) exams. Contrast enhanced MRI is a widely used diagnostic tool with over 30 million procedures performed annually. Currently, gadolinium-based contrast agents (GBCAs) are used for this purpose, but recently concerns have been raised about the long-term safety of the gadolinium metal ion. The study's senior author is Eric M.

A study from Vanderbilt-Ingram Cancer Center and the Department of Veterans Affairs led by Anna Vilgelm, MD, PhD, and Ann Richmond, PhD, has identified a possible second-line treatment for melanoma patients.

Studying mutant worms has led to the discovery of a receptor that reduces sensitivity to opioid side effects in these organisms. The work implicates the understudied GPR139 receptor in the toxic effect of these painkillers; the authors say GPR139 could be a useful target for increasing opioid safety. Despite side effects like addiction and dependency, opioids such as morphine and fentanyl remain the standard of care for pain relief. These drugs target the mu opioid peptide receptor (MOR).

Researchers at Karolinska Institutet in Sweden have discovered a new sensory organ that is able to detect painful mechanical damage, such as pricks and impacts. The discovery is being published in the journal 'Science'.

Extraterrestrial scientists landing in a football stadium would be struck by the sight of the crowd suddenly standing up and shouting in unison. In a similar manner, since the nineties, researchers have observed a special pattern of neuronal activity in rodents: tens of thousands of nerve cells firing in unison in a part of the brain called the hippocampus. But, like an alien scientist, the researchers have not been able to understand the "language" of the rodents' minds when these mysterious synchronous bursts occurred.

In the current issue of Cardiovascular Innovations and Applications volume 4, issue 2, pp. 121-23; DOI https://doi.org/10.15212/CVIA.2017.0069, C. Richard Conti, Jamie. B Conti, and Jeff Plasschaert from the University of Florida Medical School, Gainesville, FL, USA consider the impact of cardiac rehabilitation programmes.

In the current issue of Cardiovascular Innovations and Applications volume 4, issue 2, pp. 125-134; DOI https://doi.org/10.15212/CVIA.2019.0013, Xiaoyu Zheng, Qingyao Liao, Yue Wang, Hua Li, Xiaodong Wang, Yaohui Wang, Wentao Wu, Junlin Wang, Ling Xiao, and Jing Huang.

In the current issue of Cardiovascular Innovations and Applications volume 4, issue 2, pp. 135-141; DOI https://doi.org/10.15212/CVIA.2019.0015, Ömer Şatıroğlu, Murtaza Emre Durakoğlugil, Hüseyin Avni Uydu, Hakan Duman, Mustafa Çetin, Yüksel Çiçek, and Turan Erdoğan.

BUFFALO, N.Y. -- Higher levels of blood high-density lipoprotein (HDL) -- or good cholesterol -- may improve fatigue in multiple sclerosis patients, according to a new University at Buffalo-led study.

The pilot study, which investigated the effects of fat levels in blood on fatigue caused by multiple sclerosis, found that lowering total cholesterol also reduced exhaustion.

A new fruit fly model that mimics diseases associated with high uric acid levels, such as gout and kidney stones, has revealed new targets for developing treatments for these diseases. Pankaj Kapahi of Buck Institute and colleagues report these findings in a new study published 15th August in PLOS Genetics.

There's currently no known way to prevent older adults with mild cognitive impairment (MCI) from developing Alzheimer's disease.

But there may be a safe and feasible non-pharmacological treatment that may help patients living with MCI, according to a small pilot study in the current issue of the Journal of Alzheimer's Disease led by a neurologist and researcher with Wake Forest Baptist Health.

Research scientists representing Regenstrief Institute, Indiana University School of Medicine and IU Richard M. Fairbanks School of Public Health at IUPUI are joining - and in some cases leading - the global health conversation at the 17th World Congress of Medical and Health Informatics (MedInfo).