PHILADELPHIA - A machine learning-based tool was able to predict the risk of malignancy among patients presenting with multiple pulmonary nodules and outperformed human experts, previously validated mathematical models, and a previously established artificial intelligence tool, according to results published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

SILVER SPRING, Md.--A systematic review of multiple randomized controlled studies among adults with overweight or obesity showed that greater engagement in self-monitoring using digital health tools was associated with significant weight loss, according to a paper published online in Obesity, The Obesity Society's flagship journal. This is the first comprehensive systematic review to examine the relationship between digital self-monitoring and weight loss.

In the largest genome-wide association study of glaucoma comparing the genes of 34,179 people with the disease to 349,321 control subjects, an international consortium of researchers identified 44 new gene loci and confirmed 83 previously reported loci linked to glaucoma. Loci are considered "genetic street addresses," denoting a specific location on a gene.

The study's authors hope the identification of these genes will lead to new treatment targets for this incurable eye disease that is a leading cause of blindness worldwide.

In the journal Nature Communications, scientists of the German Center for Neurodegenerative Diseases (DZNE) report new findings on the mechanisms of "Niemann-Pick type C disease" (NPC). This rare brain disorder mainly manifests in childhood and includes severe neurological and psychiatric symptoms. Researchers led by Dr. Sabina Tahirovic have now found evidence that already at an early stage, NPC is associated with neuroinflammation and that this condition is triggered by impaired intracellular lipid transport.

CLEVELAND, Ohio (Feb 24, 2021)--The aging population combined with increasing obesity rates has resulted in more women experiencing pelvic organ prolapse. Common treatment options include pelvic reconstructive surgery or the use of pessaries to prop up descending organs. A new study evaluated the long-term effectiveness of pessaries, as well as reasons why women discontinued their use. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS).

ATLANTA - FEBRUARY 24, 2021 - New study reports that early in the 2020 pandemic in the United States, one-third of cancer survivors worried about treatment and cancer care disruptions. Using a mixed methods approach, investigators utilized survivors' own words to more deeply describe their experiences and worries about the pandemic's impact on their overall health.

NEW YORK (February 24, 2021) -- Nearly half of women with uncomplicated urinary tract infections received the wrong antibiotics and almost three-quarters received prescriptions for longer than necessary, with inappropriately long treatment durations more common in rural areas, according to a study of private insurance claims data published today in Infection Control & Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America.

LOS ANGELES (Feb. 11, 2021) -- A new strain of the coronavirus in Southern California, first reported last month by Cedars-Sinai, is rapidly spreading across the country and around the world as travelers apparently carry the virus with them to a growing list of global destinations, according to new research published today in the peer-reviewed Journal of the American Medical Association (JAMA).

According to a new study published in The American Journal of Human Genetics, more than one third of genetic variants that increase the risk of coronary artery disease regulate the expression of genes in the liver. These variants have an impact on the expression of genes regulating cholesterol metabolism, among other things. The findings provide valuable new insight into the genetics of coronary artery disease.

Tohoku University scientists have shown that neuronal and glial circuits form a loosely coupled super-network within the brain. Activation of the metabotropic glutamate receptors in neurons was shown to be largely influenced by the state of the glial cells. Therefore, artificial control of the glial state could potentially be used to enhance the memory function of the brain.

The findings were detailed in the Journal of Physiology.

Social distancing - from mobility restrictions to complete lockdowns -- can take many weeks, possibly even months, a potentially devastating outcome for social and economic stability. One of the challenges is that the sick cannot be selectively isolated, since many of the spreaders remain pre-symptomatic for a period ranging from several days to as much as two weeks - invisible spreaders who continue to be socially active. Hence, it seems that without a population-wide lockdown isolating the carriers cannot be achieved effectively.

In the first few months of their lives, babies cry, babble, gurgle and make a variety of other peculiar sounds. It can be difficult to imagine that they are actually laying the foundations for later speech with these utterances. However, there is a determining element that proves that even their cries can be assigned to a particular language: the speech melody - or, more accurately: prosody.

Leesburg, VA, February 24, 2021--An open-access article in ARRS' American Journal of Roentgenology (AJR) describes the clinical and imaging features of axillary adenopathy detected during screening or diagnostic breast imaging after recent coronavirus disease (COVID-19) vaccination to inform the development of follow-up recommendations.

COVID-19, the disease caused by the pandemic coronavirus SARS-CoV-2, is primarily regarded as a respiratory infection. Yet the virus has also become known for affecting other parts of the body in ways not as well understood, sometimes with longer-term consequences, such as heart arrhythmia, fatigue and "brain fog."

BUFFALO, N.Y. -- A new study illuminates how a gene called HAND2 may have a hand in the timing of human labor.