When it comes to certain molecules, shape makes all the difference. The shape of limonene, for instance, a compound produced by citrus fruits, determines whether it tastes like orange juice or turpentine. In the case of therapeutics, the 3D shape of a molecule can be critical to activity.
Monday, July 6, 2018 - Johns Hopkins researchers in collaboration with Insilico Medicine, a biotechnology company based in Rockville Maryland, identify that silencing of the GULP1 gene expression by methylation plays an important role in ovarian carcinogenesis.
Transplantation followed by antiviral therapy cured hepatitis C in 100 percent of patients receiving kidneys from infected donors
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Bottom Line: Postmenopausal bleeding is a common symptom among most women with endometrial cancer but most women with postmenopausal bleeding won't be diagnosed with endometrial cancer, findings that raise questions about how to best manage postmenopausal bleeding for the early detection of endometrial cancer.
For the first time, researchers at University of California San Diego School of Medicine and Imperial College London, with international collaborators, have determined that Kawasaki Disease (KD) can be accurately diagnosed on the basis of the pattern of host gene expression in whole blood. The finding could lead to a diagnostic blood test to distinguish KD from other infectious and inflammatory conditions.
Results of the international study published on August 6 in JAMA Pediatrics.
Cocaine relapse was significantly reduced in a preclinical model when brain-derived neurotropic factor (BDNF) was applied to the nucleus accumbens deep in the brain immediately before cocaine-seeking behavior, report investigators at the Medical University of South Carolina (MUSC) in an article published online in June 2018 by Addiction Biology. "We discovered that a very common protein in the brain has an additional significant role in addiction relapse," says lead author Ana-Clara Bobadilla, Ph.D., a postdoctoral scholar in the laboratory of Peter Kalivas, Ph.D., at MUSC.
HOUSTON - (Aug. 3, 2018) - Rice University researchers have found that fracture-resistant "rebar graphene" is more than twice as tough as pristine graphene.
Graphene is a one-atom-thick sheet of carbon. On the two-dimensional scale, the material is stronger than steel, but because graphene is so thin, it is still subject to ripping and tearing.
An avalanche is an extremely complex event, with countless parameters and physical variables coming into play from the time the avalanche is triggered until it ends. Johan Gaume, a researcher in the Laboratory of Cryospheric Sciences (CRYOS) and SLF,* has created a highly accurate digital simulation of an avalanche based on these parameters. His work, which offers unprecedented insight into how avalanches work, could be used to improve risk management in the mountains. It was published today in Nature Communications.**
Almost everyone who eats fast food is familiar with the frustration of trying to squeeze every last drop of ketchup out of the small packets that accompany french fries.
A collaborative study by researchers at Tokyo Institute of Technology has developed a new technique to decode motor intention of humans from Electroencephalography (EEG). This technique is motivated by the well documented ability of the brain to predict sensory outcomes of self-generated and imagined actions utilizing so called forward models. The method enabled for the first time, nearly 90% single trial decoding accuracy across tested subjects, within 96 ms of the stimulation, with zero user training, and with no additional cognitive load on the users.