Geneticists from Trinity College Dublin have discovered how a specific genetic mutation called H3K27M causes a devastating, incurable childhood cancer, known as diffuse midline glioma (DMG), and - in lab studies working with model cell types - successfully reverse its effects to slow cancer cell growth with a targeted drug.
NOTICE: This summary has been updated to correct misspellings of the last names of both Perspective authors. The Perspective authors are Sanne Cottaar and Paula Koelemeijer. We apologize for our error.
Of the nearly 100 SARS-CoV-2 vaccines currently undergoing clinical trials, only seven are delivered intranasally - despite this vaccine type's long success in providing protection from influenza. In a Perspective, Frances Lund and Troy Randall argue that intranasal vaccines could be beneficial in the continued fight against COVID-19, especially considering respiratory viruses like SARS-CoV-2 predominantly enter the nasal passage first. Currently authorized COVID-19 vaccines are delivered via intramuscular injection, where they elicit systemic immune responses and central immune memory.
Like dreaming of walking through a world they've not yet experienced, the retinas of neonatal mice practice for what mature eyes must later process by generating spontaneous patterns of activity that mimic the perception of directional movement through space, according to a new study. Essential functions in the mammalian visual system, including the ability to locate objects and detect motion, are present even at the first onset of vision. Optic flow, the perceived relative motion of objects and surfaces that seemingly stream by a field of vision during movement, is one of these functions.
Advances in microscopy have enabled researchers to picture loops of DNA strands for the first time. The images reveal how the human genome organises itself in three-dimensional space at much higher resolution than previously possible.
Manipulating RNA can allow plants to yield dramatically more crops, as well as increasing drought tolerance, announced a group of scientists from the University of Chicago, Peking University and Guizhou University.
In initial tests, adding a gene encoding for a protein called FTO to both rice and potato plants increased their yield by 50% in field tests. The plants grew significantly larger, produced longer root systems and were better able to tolerate drought stress. Analysis also showed that the plants had increased their rate of photosynthesis.
A new study showed that a wearable computer vision device can reduce collisions for both people who are blind or those who are visually impaired and using a long cane and/or guide dog by 37 percent, compared to using other mobility aids alone.
New European Union regulations on batteries could offer a huge boost to the global decarbonisation mission - but only if it leverages its political and economic weight to ensure a fairer global marketplace.
According to a team of scientists and researchers writing in Science, the new regulations, due to come into force from January 2022, have the potential to unify policy on approaches such as recycling, use of recycled raw materials, and creating a circular economy.
Newly-hatched pterosaurs may have been able to fly but their flying abilities may have been different from adult pterosaurs, according to a new study.
Pterosaurs were a group of flying reptiles that lived during the Triassic, Jurassic and Cretaceous Periods (228 to 66 million years ago). Due to the rarity of fossilised pterosaur eggs and embryos, and difficulties distinguishing between hatchlings and small adults, it has been unclear whether newly-hatched pterosaurs were able to fly.
A research team led by Wim Annaert (VIB-KU Leuven) uncovered the early assembly of gamma-secretase, a protein complex linked to numerous cellular processes including the development of Alzheimer's disease. In a first step, two dimeric subcomplexes are formed, which independently exit the ER and only afterwards assemble into a four-subunit complex. This 'buckle up' mechanism is thought to prevent premature assembly and activity. The new insights are very relevant, as gamma-secretase is an important potential therapeutic target for Alzheimer's and other conditions.
In a new study, published recently in the journal Circulation Research, scientists discover how the production of protective molecules known as specialised pro-resolving mediators (SPM) is altered in patients with COVID-19.
The results suggest that treatments which increase SPM production, such as dexamethasone or SPM based drugs, could play a key role in limiting inflammation in these patients.
Currently there is little understanding around the mechanisms that lead to uncontrolled inflammation in patients with COVID-19.
Alexandria, Va., USA - Jiachen Lin, Harvard School of Dental Medicine, Boston, Mass., USA., presented the poster "Burden of Oral Diseases in Emerging Countries: A Prediction Model" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Meeting of the Canadian Association for Dental Research (CADR), on July 21-24, 2021.
Since early 2019, researchers have been recording and analysing marsquakes as part of the InSight mission. This relies on a seismometer whose data acquisition and control electronics were developed at ETH Zurich. Using this data, the researchers have now measured the red planet's crust, mantle and core - data that will help determine the formation and evolution of Mars and, by extension, the entire solar system.
Mars once completely molten
Astronomers using two of the world's most powerful radio telescopes have made a detailed and sensitive survey of a large segment of our home galaxy -- the Milky Way -- detecting previously unseen tracers of massive star formation, a process that dominates galactic ecosystems. The scientists combined the capabilities of the National Science Foundation's Karl G. Jansky Very Large Array (VLA) and the 100-meter Effelsberg Telescope in Germany to produce high-quality data that will serve researchers for years to come.
Around 470 million years ago, plants began to conquer the terrestrial surfaces. The first examples had a small axis terminated by a structure capable of forming spores, almost like current mosses. The appearance of plant organs mediated the explosive radiation of land plants, which shaped the surface of our planet and allowed the establishment of terrestrial animal life.