Body

A new study indicates that many young adult female cancer survivors do not receive adequate information about their fertility as part of their survivorship care after completing treatment, despite having concerns about their ability to bear children in the future. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the findings point to the need for better resources to support survivors in making informed decisions about their reproductive options after treatment is completed.

SYRACUSE, NEW YORK -- A hominin in the same genus as humans and an ape nicknamed "Laia" that might provide clues to the origin of humans are among the discoveries identified by the SUNY College of Environmental Science and Forestry (ESF) as the Top 10 New Species of 2016.

Bottom Line: The investigational anticancer therapeutic abemaciclib, which targets CDK4 and CDK6, showed durable clinical activity when given as continuous single-agent therapy to patients with a variety of cancer types, including breast cancer, non-small cell lung cancer (NSCLC), glioblastoma, and melanoma, according to results from a phase I clinical trial.

Journal in Which the Study was Published: Cancer Discovery, a journal of the American Association for Cancer Research.

New findings describe a novel strategy for predicting how circulating influenza viruses will evolve, an approach that may help scientists create better seasonal influenza vaccines.

MADISON, Wis. -- During the 2014-15 flu season, the poor match between the virus used to make the world's vaccine stocks and the circulating seasonal virus yielded a vaccine that was less than 20 percent effective.

While this year's vaccine is a much better match to the circulating seasonal strains of influenza, the shifty nature of the virus and the need to pick the viruses used to make global vaccine stocks well before the onset of the flu season can make vaccine strain selection a shot in the dark.

(BOSTON, May 23, 2016) -- Two new studies raise enough questions about a possible link between childhood cancer and light therapy for newborn jaundice that clinicians should exercise caution in prescribing the treatment for infants whose jaundice is likely to resolve on its own, a pediatric oncologist from Dana-Farber/Boston Children's Cancer and Blood Disorders Center argues in an editorial published today by the journal Pediatrics.

Infarct (tissue damage) volume and hyperglycemia (high blood glucose) were associated with poor neurological outcomes after childhood stroke but hypertension and fever were not, according to an article published online by JAMA Neurology.

After pediatric patients experience an arterial ischemic stroke, there are no evidence-based guidelines available for the best management of blood pressure, blood glucose levels and temperature.

SEATTLE -- Chatting on the phone with a "sleep coach" and keeping a nightly sleep diary significantly improve sleep quality and reduce insomnia in women through all stages of menopause, according to a new study published today in JAMA Internal Medicine.

The study also found that such phone-based cognitive behavioral therapy significantly reduced the degree to which hot flashes, or vasomotor symptoms, interfered with daily functioning.

Two hundred and fifty million years ago, life on earth was in a tail-spin--climate change, volcanic eruptions, and rising sea levels contributed to a mass extinction that makes the death of the dinosaurs look like child's play. Marine life got hit hardest--96% of all marine species went extinct. For a long time, scientists believed that the early marine reptiles that came about after the mass extinction evolved slowly, but the recent discovery of a strange new fossil brings that view into question.

Nanosized Trojan horses created from a patient's own immune cells have successfully treated inflammation by overcoming the body's complex defense mechanisms, perhaps leading to broader applications for treating diseases characterized by inflammation, such as cancer and cardiovascular diseases.

An international team, led by researchers at Houston Methodist Research Institute, described the creation of nanoparticles called leukosomes and evaluated their ability to treat localized inflammation in the May 23 issue of Nature Materials (early online).

Our bodies are constantly and successfully fighting off the development of cells that lead to tumours - but when there is disruption to this process cancer is free to develop.

Walter and Eliza Hall Institute researchers, led by Dr Sandra Nicholson and Dr Nicholas Huntington, together with colleagues from the Queensland Institute of Medical Research, are investigating ways to 'switch on' our Natural Killer (NK) cells.

Whether it's paying the electric bill or taking the clothes out of the dryer, there are many daily tasks that we fully intend to complete and then promptly forget about. New research suggests that linking these tasks to distinctive cues that we'll encounter at the right place and the right time may help us remember to follow through. The research is published in Psychological Science, a journal of the Association for Psychological Science.

The 52nd Annual Meeting of the American Society of Clinical Oncology (ASCO) will include more than 70 research presentations by Dana-Farber Cancer Institute investigators and will attract as many as 30,000 oncology professionals from around the world. Held June 3 to 7 in Chicago at McCormick Place, presentations will cover the latest findings across oncology.

Here is a brief look at select studies Dana-Farber and Dana-Farber/Boston Children's Cancer and Blood Disorders Center researchers are presenting at the meeting:

SAN DIEGO - An endoscopist's knowledge of a positive Cologuard test improves colonoscopy performance, according to a poster presentation at last week's Digestive Disease Week conference.

Cologuard is an at-home, stool-DNA colorectal cancer screening test that has been approved by the U.S. Food and Drug Administration. This test, available by prescription only, is reimbursed by Medicare and covered by an increasing number of commercial health care plans.

(Boston) -- The CRISPR-Cas9 system has come to be known as the quintessential tool that allows researchers to edit the DNA sequences of many organisms and cell types. However, scientists are also increasingly recognizing that it can be used to activate the expression of genes. To that end, they have built a number of synthetic gene activating Cas9 proteins to study gene functions or to compensate for insufficient gene expression in potential therapeutic approaches.