Body

In a study that included more than 20,000 adults in China with high blood pressure but without a history of stroke or heart attack, the combined use of the hypertension medication enalapril and folic acid, compared with enalapril alone, significantly reduced the risk of first stroke, according to a study appearing in JAMA. The study is being released to coincide with its presentation at the American College of Cardiology Annual Scientific Session.

New research found that bat activity was generally lower in street-lit areas than in dark locations with similar habitat, which means the popular belief that street lighting is attractive to common bats is not true and they don't benefit from them when feeding on the insects that congregated around them.

Scientists at Benaroya Research Institute at Virginia Mason (BRI) have made an unexpected discovery that overturns a longstanding belief in the biological sciences. Research, led by Chris Amemiya, PhD, a member at BRI, and primarily conducted by Joyce Tang, was published online in today's issue of Current Biology. The research demonstrates that chitin, a molecule that was previously thought to be absent in vertebrates and that has been shown to trigger an allergy/immune reaction in mammals, is endogenously produced in fishes and amphibians.

Researchers in the UK have, for the first time, shown how exhaust pollution from diesel engines is able to affect nerves within the lung. Air pollution is a significant threat to health, they say, and identifying potential mechanisms linking exposure to diesel exhaust and the exacerbation of respiratory diseases may lead to treatments for those affected.

Hair and teeth are ectodermal appendages that share common developmental mechanisms. However, the major structural components making up hair and teeth are very distinct. The hair shaft is essentially made of keratin filaments that are highly cross-linked. Tooth enamel matrix is primarily composed of enamel proteins (amelogenin, ameloblastin) that are degraded and replaced by minerals during enamel maturation. Fully mineralized enamel contains a small fraction of cross-linked organic material that has not been fully characterized.

living beings can keep gene expression in check -- which might partly explain the uncontrolled gene expression found in many cancers.

"Using yeast as a model organism, we studied the Tup1 protein, a negative regulator of gene expression," says Biology Professor Emanuel Rosonina, adding, "This protein binds to some genes and blocks their expression, helping to ensure genes that shouldn't be turned on remain inactive."

Healthy young adults who don't consume caffeine regularly experienced greater rise in resting blood pressure after consumption of a commercially available energy drink -- compared to a placebo drink -- thus raising the concern that energy drinks may increase the risk of cardiac events, Mayo Clinic researchers found.

Results of the study will be presented Saturday, March 14, at the American College of Cardiology's 64th Annual Scientific Session in San Diego.

Our skeletons hold tell-tale signs that show that human bipedalism - walking upright and on two feet - are unique to humans especially when compared to our closest living relatives, apes. Exactly when these signs first appear in our evolutionary history is one of the fundamental questions driving the study of human evolution, or Palaeoanthropology, today.

Metastatic melanoma is the leading cause of skin cancer deaths in the United States; once melanoma has spread (metastasized), life expectancy for patients can be dramatically shortened. At present, the reference therapy for patients diagnosed with metastatic melanoma is Dacarbazine (DTIC), which is associated with poor patient outcomes.

Damage to the spinal cord rarely heals because the injured nerve cells fail to regenerate. The regrowth of their long nerve fibers is hindered by scar tissue and molecular processes inside the nerves. An international team of researchers led by DZNE scientists in Bonn report that help might be on the way from an unexpected quarter: in animal studies, the cancer drug epothilone reduced the formation of scar tissue in injuries to the spinal cord and stimulated growth in damaged nerve cells. Both promoted neuronal regeneration and improved the animals' motor skills.

In the continuing debate over how much vitamin E is enough, a new study has found that high levels of blood lipids such as cholesterol and triglycerides can keep this essential micronutrient tied up in the blood stream, and prevent vitamin E from reaching the tissues that need it.

The research, just published in the American Journal of Clinical Nutrition, also suggested that measuring only blood levels may offer a distorted picture of whether or not a person has adequate amounts of this vitamin, and that past methods of estimating tissue levels are flawed.

Many animals, including humans, acquired essential 'foreign' genes from microorganisms co-habiting their environment in ancient times, according to research published in the open access journal Genome Biology. The study challenges conventional views that animal evolution relies solely on genes passed down through ancestral lines, suggesting that, at least in some lineages, the process is still ongoing.

The origin of life is still a mystery with many unsolved puzzles. How were molecules created? How did they assemble into large structures? Among the conundrums, the "homochirality" phenomenon upon which amino acids and sugars form is particularly fascinating. University of Akron A. Schulman Professor of Polymer Science Tianbo Liu has discovered that Mother Nature's clear bias toward certain amino acids and sugars and against others isn't accidental.

oday marked the publication of the first ever genome-wide association study of rosacea, a common and incurable skin disorder. Led by Dr. Anne Lynn S. Chang of Stanford University's School of Medicine, and co-authored by 23andMe, the study is the first to identify genetic factors for this condition.

The prevalence of type 2 diabetes among 25,000 patients with familial hypercholesterolemia (a genetic disorder characterized by high low-density lipoprotein [LDL] cholesterol levels) was significantly lower than among unaffected relatives, with the prevalence varying by the type of gene mutation, according to a study in the March 10 issue of JAMA.