Body

Baby it’s warm inside … we have 200 microbes for every human cell. Agricultural Research Service

We are all populated by microbes – helpful or otherwise – which form a community known as a microbiome. Recent research by Ryan Newton and co-workers has shown that sewage-based analysis of the human microbiome can be used to diagnose health issues at a population level.

Researchers from Manchester, working with scientists in California, have found that certain molecules long thought to promote cancer growth, in fact suppress tumours, suggesting that therapeutic approaches should aim to restore, rather than block, their activity.

Geneticists from the University of Leicester have discovered that millions of modern Asian men are descended from 11 powerful dynastic leaders who lived up to 4,000 years ago - including Mongolian warlord Genghis Khan.

The study, which is funded by the Wellcome Trust and published in the journal European Journal of Human Genetics, examined the male-specific Y chromosome, which is passed from father to son, in more than 5,000 Asian men belonging to 127 populations.

Why men have more heart disease than premenopausal women has been unclear, but a new study shows that the sex hormones testosterone and estrogen alter cardiovascular risk factors in a way that raises a man's risk of heart disease. Results of the study will be presented Saturday at the Endocrine Society's 97th annual meeting in San Diego.

The molecular complex that guides an important class of proteins to correct locations in cell membranes does so by forming a dimeric structure with a protective pocket, according to a new report. This structure shields tail-anchored membrane proteins - which have roles in a wide variety of cellular functions from neurotransmitter release to insulin production - from harmful aggregation or misfolding as they move through the inner environment of a cell. The findings clarify the mechanism behind a fundamental biological process.

The composition of intestinal bacteria and other micro-organisms--called the gut microbiota--changes over time in unhealthy ways in black men who are prediabetic, a new study finds. The results will be presented Friday at the Endocrine Society's 97th annual meeting in San Diego.

Using a mouse model of rheumatoid arthritis, scientists have discovered that a form of cellular immunotherapy by intravenous administration of monocytic myeloid-derived suppressor cells, or M-MDSCs, might be an effective treatment for the disease in humans. In a report published in the March 2015 issue of the Journal of Leukocyte Biology, researchers show that M-MDSCs are capable of inhibiting T cell proliferation, as well as B cell proliferation and antibody production. As a result, the arthritic mice experienced improvements in their symptoms.

Exposure to low doses of hormone-disrupting chemicals early in life can alter gene expression in the liver as well as liver function, increasing the susceptibility to obesity and other metabolic diseases in adulthood, a new study finds. Results of the animal study will be presented Friday at the Endocrine Society's 97th annual meeting in San Diego.

Brief exposure in infancy to several industrial chemicals that are common in the human environment, particularly bisphenol A (BPA), caused fatty liver disease in adulthood, the researchers found in rats.

New research with mice undercuts widely held belief that ubiquinone protects cells against damage from free radicals.

The popular dietary supplement ubiquinone, also known as Coenzyme Q10, is widely believed to function as an antioxidant, protecting cells against damage from free radicals. But a new study by scientists at McGill University finds that ubiquinone is not a crucial antioxidant -- and that consuming it is unlikely to provide any benefit.

The St. Jude Children's Research Hospital--Washington University Pediatric Cancer Genome Project reports that a highly aggressive form of leukemia in infants has surprisingly few mutations beyond the chromosomal rearrangement that affects the MLL gene. The findings suggest that targeting the alteration is likely the key to improved survival. The research appeared online ahead of print this week in the scientific journal Nature Genetics.

Sitting for many hours per day is associated with increased coronary artery calcification, a marker of subclinical heart disease that can increase the risk of a heart attack, according to research scheduled for presentation at the American College of Cardiology's 64th Annual Scientific Session in San Diego. Coronary artery disease is the most common type of heart disease and the leading cause of death in the United States.

A new study by researchers at the Intermountain Medical Center Heart Institute has found that screening for and treating depression could help to reduce the risk of heart disease in patients with moderate to severe depression.

A new study scheduled for presentation at a meeting of the American College of Cardiology found that screening for and treating depression could help to reduce the risk of heart disease in patients with moderate to severe depression.

Male partners of infertile obese females may increase the odds of conceiving a child by improving their own weight and dietary habits, preliminary results from a pilot study from Canada suggest. The results will be presented Thursday, March 5, at ENDO 2015, the annual meeting of the Endocrine Society in San Diego.

Exposure to hormone-altering chemicals called phthalates - which are found in many plastics, foods and personal care products - early in pregnancy is associated with a disruption in an essential pregnancy hormone and adversely affects the masculinization of male genitals in the baby, according to research led by the University of Pittsburgh Graduate School of Public Health.