Body

Life has adapted to all sorts of extreme environments on Earth, among them, animals like the deer mouse, shimmying and shivering about, and having to squeeze enough energy from the cold, thin air to fuel their bodies and survive.

Cancer researchers from the University of Zurich have identified a key signaling pathway in B-cell lymphoma, a malignant type of blood cancer. They demonstrate that the signaling pathway can be blocked using compounds that are already in clinical development. This finding might be extremely important for the diagnosis, prognosis and treatment of this disease in the future.

In a breakthrough in the understanding of how cancer does its deadly work, researchers at the University of Virginia School of Medicine have shown that many cancers - including nearly all pancreatic cancers - enslave and deform mitochondria, the powerhouses of cells, to create an environment more conducive to tumor growth.

Physical activity that makes you puff and sweat is key to avoiding an early death, a large Australian study of middle-aged and older adults has found.

The researchers followed 204,542 people for more than six years, and compared those who engaged in only moderate activity (such as gentle swimming, social tennis, or household chores) with those who included at least some vigorous activity (such as jogging, aerobics or competitive tennis).

Nutrition and metabolism are closely linked with reproductive health. Several reproductive disorders including polycystic ovary syndrome, amenorrhea, and ovarian cancer have been linked to malnutrition, diabetes, and obesity. Furthermore, fasting in numerous species can result in decreased fertility, because the development of immature egg cells, called oocytes, is arrested. Understanding how nutrients accumulate in immature oocytes will provide valuable insights into the link between metabolic disease and reproductive dysfunction.

While testosterone replacement therapies may be controversial in males, new research may extend this controversy to females too. That's because research involving mice suggests that there is an association between low levels of androgens (which includes testosterone), and atherosclerosis and obesity in females.

Genetic studies in humans, zebrafish and mice have revealed how two different types of genetic variations team up to cause a rare condition called Hirschsprung's disease. The findings add to an increasingly clear picture of how flaws in early nerve development lead to poor colon function, which must often be surgically corrected. The study also provides a window into normal nerve development and the genes that direct it.

The results appear in the April 2 issue of the American Journal of Human Genetics.

A vital self-destruct switch in cells is hijacked - making some pancreatic and non small cell lung cancers more aggressive, according to new research which found that mutations in the KRAS gene interferes with protective self-destruct switches, known as TRAIL receptors, which usually help to kill potentially cancerous cells.

Methicillin-resistant Staphylococcus aureus (MRSA), an antibiotic-resistant superbug, can cause life-threatening skin, bloodstream and surgical site infections or pneumonia. Researchers at the University of California, San Diego School of Medicine now report that cigarette smoke may make matters worse. The study, published March 30 by Infection and Immunity, shows that MRSA bacteria exposed to cigarette smoke become even more resistant to killing by the immune system.

Based on research in fruit flies, it has long been suspected that the most common mutation linked to both sporadic and familial Parkinson's disease (PD) wreaks its havoc by altering the function of mitochondria in neurons that produce the neurotransmitter dopamine.

Using stem cells derived from patients who have PD, scientist at the Buck Institute have confirmed that finding in human cells for the first time.

In a new paper, Buck researchers provide a valuable tool for testing potential treatments for the progressive, incurable neurodegenerative disease.

The findings, which have been published in the American Journal of Clinical Nutrition, are in line with previous studies of eating habits that indicated a link between high consumption of dairy products and a reduced risk of type 2 diabetes.

However, the new study indicates that it is high-fat dairy products specifically that are associated with reduced risk.

Researchers found that consuming the fish herring and mackerel, as well as three kinds of fish oils, raised blood levels of the fatty acid 16:4(n-3), which experiments in mice suggest may induce resistance to chemotherapy used to treat cancer, according to a study published online by JAMA Oncology.

Patients with cancer often adopt lifestyle changes and those changes often include the use of supplements. But there is growing concern about the use of supplements while taking anticancer drugs and the possible effect on treatment outcomes, according to the study background.

Supplemental folic acid can enhance blood vessel dilation in older adults, according to Penn State researchers, suggesting that folic acid supplements may be an inexpensive alternative for helping older adults to increase skin blood flow during heat waves and reduce cardiovascular events.

When Jonas the lemur died in January, just five months short of his thirtieth birthday, he was the oldest of his kind. A primate called a fat-tailed dwarf lemur, Jonas belonged to a long-lived clan. Dwarf lemurs live two to three times longer than similar-sized animals.

In a new study, Duke University researchers combed through more than 50 years of medical records on hundreds of dwarf lemurs and three other lemur species at the Duke Lemur Center for clues to their exceptional longevity.

Inhalable particles include all particulate matter with a diameter smaller than 10 micrometers (PM10). In this group a distinction is made between even finer particles smaller than 2.5 micrometers (PM2.5) in diameter, which can deeply enter the lung, and ultrafine particles with diameters less than 0.1 micrometers (100 nanometers), which can also enter the blood stream.