La Jolla, Calif., January 20, 2016 -- Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have solved the atomic structure of a unique ubiquitin ligase complex. Ubiquitin is best known for its role in protein degradation, but more recently seen as important for cell signaling, DNA repair, anti-inflammatory, and immune responses.
The study, published today in Nature, opens the door for developing a novel class of drug targets for cancer as well as inflammatory diseases such as rheumatoid arthritis, Crohn's disease and psoriasis.