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HOUSTON ? A Phase II trial led by researchers at The University of Texas MD Anderson Cancer Center found that BK virus (BKV)-specific T cells from healthy donors were safe and effective as an off-the-shelf therapy for BKV-associated hemorrhagic cystitis (BKV-HC), a painful complication common after allogeneic stem cell transplants for patients with leukemia or lymphoma. The study was published today in the Journal of Clinical Oncology.
Boston, MA (May 1, 2021) - A new study, presented today at the AATS 101st Annual Meeting, and simultaneously published in the Journal of the American College of Cardiology, finds that patients suffering from severe mitral regurgitation should be carefully screened and counselled before undergoing transcatheter edge-to-edge mitral repair (TEER). Data showed that up to 95 percent of patients who needed surgery after failed TEER could not have their valves repaired, and needed mitral valve replacement to resolve the issue.
The Worldwide Innovative Network in personalized cancer medicine consortium - WIN Consortium announces the publication of the Digital Display Precision Predictor: the prototype of a global biomarker model to guide treatments with targeted therapy and predict progression-free survival for cancer patients in NPJ Precision Oncology (10.1038/s41698-021-00171-6)
Medical researchers at Flinders University have established a new link between high body mass index (BMI) and breast cancer survival rates - with clinical data revealing worse outcomes for early breast cancer (EBC) patients and improved survival rates in advanced breast cancer (ABC).
In a new study published in a top breast cancer journal- researchers evaluated data from 5 thousand patients with EBC and 3496 with ABC to determine associations between BMI and survival rates across both stages.
Most detailed study to date including 345,000 people from 48 randomised clinical trials finds that blood pressure-lowering medication is effective in adults regardless of starting blood pressure level.
Each 5mmHg reduction in systolic blood pressure lowered the relative risk of cardiovascular events by around 10%, even in people with normal blood pressure and those who had never had a heart attack or stroke.
Scientists have been able to track how a multi-drug resistant organism is able to evolve and spread widely among cystic fibrosis patients - showing that it can evolve rapidly within an individual during chronic infection. The researchers say their findings highlight the need to treat patients with Mycobacterium abscessus infection immediately, counter to current medical practice.
A survey of over 32,000 caregivers of youth in Chicago Public Schools found that around a quarter of children and adolescents were described as stressed, anxious, angry or agitated after pandemic-related school closures and the switch to remote learning. Around a third of youth were described by caregivers as lonely and only one-third were described as having positive social and peer relationships. Across the board, caregivers reported significantly worse psychological well-being after school closures as compared to before. Findings were published in the journal JAMA Network Open.
WASHINGTON, D.C. (APRIL 29, 2021) - Results from a new study find a broad range of patients who typically undergo revascularization for stable ischemic heart disease (SIHD) in the U.S. did not meet enrollment criteria for the ISCHEMIA trial. The data, which was presented today as late-breaking clinical science at the Society for Cardiovascular Angiography & Interventions (SCAI) 2021 Scientific Sessions, demonstrates a minority of SIHD patients referred for coronary intervention in contemporary practice clearly resemble those enrolled in the ISCHEMIA trial.
When heavy ions, accelerated to the speed of light, collide with each other in the depths of European or American accelerators, quark-gluon plasma is formed for fractions of a second, or even its "cocktail" seasoned with other particles. According to scientists from the IFJ PAN, experimental data show that there are underestimated actors on the scene: photons. Their collisions lead to the emission of seemingly excess particles, the presence of which could not be explained.
CLEVELAND--Using ultra-high field magnetic resonance imaging (MRI) to map the brains of people with Down syndrome (DS), researchers from Case Western Reserve University, Cleveland Clinic, University Hospitals and other institutions detected subtle differences in the structure and function of the hippocampus--a region of the brain tied to memory and learning.
New Haven, Conn. -- The choice between two non-invasive diagnostic tests is a common dilemma in patients who present with chest pain. Yale cardiologist Rohan Khera, MD, MS, and colleagues have developed ASSIST©, a new digital decision-aiding tool.
By applying machine learning techniques to data from two large clinical trials, this new tool identifies which imaging test to pursue in patients who may have coronary artery disease or CAD, a condition caused by plaque buildup in the arterial wall.
Amsterdam, April 29, 2021 - The clinical presentation and underlying biology of Parkinson's disease (PD) varies significantly, but attempts to cluster cases into a limited number of subtypes have questionable applicability and relevance, reports the international Task Force for PD Subtypes in the Journal of Parkinson's Disease.
CLEVELAND - In a Correspondence article published in the April 29, 2021 issue of the New England Journal of Medicine, researchers from University Hospitals (UH) Cleveland Medical Center, and New York Presbyterian Hospital - Weill Cornell Medicine in New York, found a substantial reduction in the use of minimally invasive surgery for cervical cancer after publication of the results a major study called the Laparoscopic Approach to Cervical Cancer (LACC) in November 2018.
Researchers at Karolinska Institutet and the Public Health Agency of Sweden have studied newborn babies whose mothers tested positive for SARS-CoV-2 during pregnancy or childbirth. The results show that although babies born of test-positive mothers are more likely to be born early, extremely few were infected with COVID-19. The study, which is published in the esteemed journal JAMA, supports the Swedish recommendation not to separate mother and baby after delivery.
Alzheimer's disease is characterized by the abnormal accumulation and spread of the tau protein in the brain. An international study can now show how tau spreads according to four distinct patterns that lead to different symptoms with different prognoses of the affected individuals. The study was published in Nature Medicine.