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In early July, the German Institute for Quality and Efficiency in Health Care (IQWiG) conducted two early benefit assessments to investigate whether certain drug combinations with pembrolizumab have advantages in comparison with the respective appropriate comparator therapy for patients with metastatic squamous or non-squamous non-small cell lung cancer (NSCLC). Due to a contradictory presentation of the operationalization of the key outcome "overall survival" in the drug manufacturer's dossiers, the presented data were not interpretable, however.
A study into the impact of flavoured e-cigarettes, on allergic airways disease, suggests that some flavours may worsen the severity of diseases such as asthma. For the first time a model of asthma was used to investigate the effect of a range of popular e-cigarette flavours, with and without nicotine.
The use of e-cigarettes has dramatically increased in the past few years especially among younger smokers - an estimated nine percent of 18-24 year olds in the United States are current e-cigarette users.
Individuals who make concrete plans to meet their goals may engage in more physical activity, including visits to the gym, compared to those who don't plan quite so far ahead, research shows. These research findings, published in Psychological Science, a journal of the Association for Psychological Science, suggest that self-reported levels of a trait called 'planfulness' may translate into real world differences in behavior.
Monash University researchers, along with industry partner Haemokinesis, have developed the world's first blood incubator using laser technology.
This technology can slash blood incubation time to just 40 seconds, compared to the current industry gold standard of five minutes.
The study shows that laser incubation can improve pre-transfusion testing for millions of patients undergoing blood transfusions across the world, including those having major surgery, women in labour or casualties of mass trauma.
New research presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD) in Barcelona, Spain (16-20 September) shows that in patients with type 1 diabetes, hospitalization for either ketoacidosis or a hyperglycaemic (high blood sugar) coma are both linked to a subsequent increase in the risk of attempting suicide. The study is by Dr Jean Michel Petit, CHU (University Hospital) Dijon, France, and colleagues.
Fluoride varnish has become a popular anti-cavity treatment for children, and it isn't hard to see why. It's relatively easy to apply, and not just for dentists or dental hygienists. Pediatricians can do it as well, with minimal instruction. The sticky varnish goes on with a brush and then dries in a few hours. There's little risk of children swallowing the fluoride, as they might with other topical treatments such as gels.
"Good morning. Bill. Please. Step onto the scale. Touch the metal pads." The device records an electrocardiogram from Bill's fingers and - more importantly - circulation pulsing that makes his body subtly bob up and down. Machine learning tools compute that Bill's heart failure symptoms have worsened.
PHILADELPHIA -- (Sept. 18, 2019) -- Researchers at The Wistar Institute have described the role of mitochondrial fission factor (MFF) in controlling survival of cancer cells, suggesting the protein could represent a promising therapeutic target. They also found that expression of MFF is regulated by Myc, a ubiquitous mediator of cell proliferation that contributes to development of many cancer types. These results were published online in the journal EBioMedicine.
LGBT+ women face barriers when accessing healthcare, according to a review published in the International Journal of Environmental Research and Public Health.
The research, led by Professor Catherine Meads of Anglia Ruskin University (ARU), examined the experiences of LGBT+ women in the UK between 2010 and 2018 by analysing numerous studies in different health areas.
It showed similar problems faced by sexual minority women, who frequently experienced ignorance and prejudice from healthcare professionals, as well as barriers when raising concerns and complaints.
PHILADELPHIA (September 19, 2019) - Disparities in rates of sexually transmitted infections (STIs) and HIV between Black/African American and Hispanic/Latino adolescents and their white counterparts are well documented. Culturally and developmentally appropriate efforts targeted to help these youth establish healthy practices to lower their risk of sexually transmitted infections are warranted. However, such interventions present unique challenges in recruiting and retaining research participants.
Non-alcoholic fatty liver disease (NAFLD) is the build-up of fat in the liver due to factors other than alcohol. It affects about a quarter of the adult population globally, but its cause remains unknown. Now, researchers have linked NAFLD to gut bacteria that produce a large amount of alcohol in the body, finding these bacteria in over 60% of non-alcoholic fatty liver patients. Their findings, publishing September 19 in the journal Cell Metabolism, could help develop a screening method for early diagnosis and treatment of non-alcoholic fatty liver.
(PHILADELPHIA) - From 2000 to 2014, rates of filled opioid prescriptions after eye surgery rose considerably, despite reduced invasiveness of these procedures, according to a new study by researchers in the Perelman School of Medicine at the University of Pennsylvania.
Early palliative care is associated with better survival in patients with advanced lung cancer, according to a study by VA Portland Health Care System and Oregon Health and Science University researchers.
New Orleans, LA - Research conducted by Suresh Alahari, PhD, Professor of Biochemistry and Genetics at LSU Health New Orleans School of Medicine, has found that metformin, a commonly prescribed drug for Type 2 Diabetes, may be effective in treating cancers that lack a protein called Nischarin. The findings are published online in the International Journal of Cancer available here.
What The Study Did: This randomized clinical trial compared the outcomes of heart attack, stroke or death from cardiovascular causes among 6,000 patients with type 2 diabetes who were treated with the glucose-lowering medications linagliptin or glimepiride.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
Authors: Nikolaus Marx, M.D., of Aachen University in Aachen, Germany, is the corresponding author.
(doi:10.1001/jama.2019.13772)