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A group of our cancer and mathematics researchers at Houston Methodist have developed a clinically-applicable mathematical model to predict patient outcomes to cancer immunotherapy. Vittorio Cristini, Ph.D., and colleagues report in the April 29 issue of Science Advances that they designed this model in a way that allows for a usable quantitative tool to clinical practice.
Sleeping sickness and Chagas disease, caused by the tropical parasites Trypanosoma brucei and Trypanosoma cruzi, constitute a significant socioeconomic burden in low-income countries of sub-Saharan Africa and Latin America, respectively. Drug development for treating these diseases is underfunded. Moreover, current treatments are outdated and difficult to administer, while drug resistance is an emerging concern. In this report, a team of researchers lead by Dr.
Digitization can do a lot in medicine, even save lives. This is shown by the specific case of an 80-year-old patient in Mainz. The passionate Apple Watch wearer showed up in the Chest Pain Unit of the University Medical Center Mainz and complained about typical chest pain, irregular pulse and an intermittent presyncopies - all possible symptoms of coronary artery disease (CAD) and thus possible harbingers of a heart attack. The ECG recorded in the CPU as well as the results from blood testing were normal.
Bethesda, MD (April 30, 2020) -- Toxin exposure appears to have contributed to dramatically higher rates of fatty liver disease among first responders to the attack on the World Trade Center on Sept. 11, 2001, according to research that was selected for presentation at Digestive Disease Week® (DDW) 2020. DDW® data will be published in the May online supplements to Gastroenterology and GIE: Gastrointestinal Endoscopy.
Women whose first baby is born at full term, but who experience complications in pregnancy, have an increased risk of preterm delivery (before 37 weeks) in their next pregnancy, finds a study from Norway published by The BMJ today.
The findings suggest that term complications may share important underlying causes with preterm delivery that persist from pregnancy to pregnancy - and could therefore help identify women at increased risk of preterm delivery, despite having had a previous term birth, say the researchers.
The research, published today in The Lancet Infectious Diseases is the fruit of joint project between investigators from around the world to conduct the largest individual patient data meta-analysis to date under the WWARN umbrella. The study found that artemether-lumefantrine (AL) and other artemisinin-based combination therapies (ACTs) were significantly more effective than quinine, the current recommended treatment.
Medical images for a wide range of diseases, including COVID-19, can now be more easily viewed, compared, and analyzed using a breakthrough web-based imaging platform developed by Massachusetts General Hospital (MGH) and collaborating researchers.
"Potentially inappropriate medications (PIMs)" are treatments that sometimes pose risks that outweigh their benefits, particularly for people who are 65 or older. About 20 to 60 percent of older adults take medicines that may be potentially inappropriate. That can increase the risk for being hospitalized, needing to visit the emergency department, having poor quality of life, and/or experiencing a harmful reaction.
As people age, cancer becomes an increasing health concern. Solid cancer tumors are cancers that don't affect the blood and instead form tumors, or growths of abnormal cells in certain parts of the body. These solid cancer tumors mainly impact people who are 65 and older.
Treatment of low-grade upper tract urothelial cancer usually involves radical surgery to remove the kidney and ureter, highlighting the need for improved treatments. An international team led by researchers at Baylor College of Medicine reports in the journal The Lancet Oncology that an innovative form of local chemotherapy using a mitomycin-containing reverse thermal gel offers a kidney-sparing treatment option for this rare cancer affecting 6,000 to 8,000 new patients in the United States every year.
From the vibrations of the rear-view mirror just as your car reaches precisely 70 miles per hour to a building that collapses when, in an earthquake, it begins to vibrate at a specific frequency, there is untapped energy that could be harnessed for propulsion.
In recent research, Andres J.Goza, found relationships between frequencies and the passive dynamics at play when vehicles move in air or water toward a better understanding of how to use these forces to enhance performance.
DALLAS – April 29, 2020 – Strategies that treat households in the broad vicinity of a recent malaria case with anti-malarial drugs, insecticides, or both could significantly reduce malaria in low-transmission settings, a challenge with approaches currently in use, a study led by UT Southwestern scientists suggests. The findings, published in the April 25, 2020, The Lancet, could bring efforts to eradicate malaria worldwide closer to fruition.
The ability to detect smells predicts recovery and long-term survival in patients who have suffered severe brain injury, a new study has found. A simple, inexpensive 'sniff test' could help doctors to accurately diagnose and determine treatment plans for patients with disorders of consciousness.
A one-hour exercise designed to increase feelings of social belonging administered during the first year of college appears to significantly improve the lives and careers of black students up to eleven years later, psychologists report. The authors say their findings suggest that targeted and timely psychological intervention can be an important tool to interrupt generational sociocultural disadvantages.
Berkeley -- Childhood vaccination may be a powerful tool in the fight against antimicrobial resistance in low- and middle-income countries, finds a new analysis led by researchers University of California, Berkeley.