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Pulmonary arterial hypertension (PAH) is an insidious disease. Symptoms may begin slowly, and even before they appear, extensive damage has caused the obstruction of small arteries leading to increased blood pressure in the lungs. By the time symptoms -- most notably, shortness of breath -- become severe enough for someone with PAH to seek care and obtain a definitive diagnosis, the patient's chances of survival at five years are slightly better than 50 percent on currently available treatments.
By André Julião | Agência FAPESP – Researchers affiliated with the University of São Paulo’s Ribeirão Preto Medical School (FMRP-USP) in Brazil have demonstrated the potential of a leukemia drug, arsenic trioxide, to treat medulloblastoma, a type of brain cancer most common in children. When they tested arsenic trioxide on cells taken from one of the most aggressive subgroups of this type of tumor, they obtained promising results in terms of tumor cell death. The drug also made the tumor cells more sensitive to radiation therapy.
Race and ethnicity did not affect pregnancy and birth outcomes in women with SARS-CoV-2 infection who gave birth at two hospitals in northern Manhattan during the height of the pandemic in New York City, according to a preliminary report from researchers at Columbia University Irving Medical Center and NewYork-Presbyterian.
The study - one of the first to examine the impact of race and ethnicity on pregnancy and birth outcomes in women with COVID-19 during the height of the pandemic in New York City -- was published in Obstetrics & Gynecology.
San Juan Capistrano, Calif. - A new study shows significant benefits of the Ellipsys® Vascular Access System in easily and safely creating durable vascular access for end-stage renal disease (ESRD) patients who require hemodialysis.
A scientific analysis of more than 2,000 brain scans found evidence for highly reproducible sex differences in the volume of certain regions in the human brain. This pattern of sex-based differences in brain volume corresponds with patterns of sex-chromosome gene expression observed in postmortem samples from the brain's cortex, suggesting that sex chromosomes may play a role in the development or maintenance of sex differences in brain anatomy.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that the blood protein vitronectin is a promising drug target for dry age-related macular degeneration (AMD), a leading cause of vision loss in Americans 60 years of age and older.
A new nanoparticle vaccine for SARS-CoV-2, the virus that causes COVID-19, has shown hints of protection and immunity in a preclinical study, safely eliciting the production of antibodies and antiviral T cell responses in mice and pigtail macaques. The vaccine generated robust immune responses with a single injection in mice - an important goal for vaccine researchers. Although more studies are needed to establish its protection, the vaccine represents a promising candidate for a badly needed, practical vaccine for COVID-19.
BOSTON - When prostate cancer progresses to a more-dangerous metastatic state, it does so by resurrecting dormant molecular mechanisms that had guided the fetal development of the prostate gland but had been subsequently switched off, say scientists from Dana-Farber Cancer Institute.
A new study shows that genetic pre-screening could reduce the number of screening tests needed to identify individuals at risk for osteoporotic fractures. Douglas P.
BOSTON - (July 20, 2020) - Every doctor recommends regular aerobic exercise, since greater aerobic fitness is important for achieving better overall health. But Joslin Diabetes Center scientists now have discovered that some benefits of aerobic exercise may be dampened by higher-than-normal blood sugar levels, a condition known as hyperglycemia.
New Rochelle, NY, July 20, 2020--A new study has shown that although 86% of women seen at an outpatient gynecology clinic had a cardiovascular risk factor and 40.1% had at least one cardiovascular symptom, the awareness of cardiovascular risk factors and symptoms was low. The study, which showed the feasibility of using a simple screening tool in the outpatient gynecology setting for cardiovascular risk assessment, is published in Journal of Women's Health, a peer-reviewed publication from Mary Ann Liebert, Inc., publishers.
Phase 2 randomised controlled trial of a recombinant adenovirus type-5-vectored COVID-19 vaccine (Ad5-vectored COVID-19 vaccine) was conducted in China in April 2020 and involved more than 500 people
The primary objective of the study was to evaluate the immune response and safety of the vaccine, and to determine the most suitable dose for a phase 3 trial
Phase 3 trials are needed to confirm whether the vaccine candidate effectively protects against SARS-CoV-2 infection
(Edmonton, AB) A new blood test that reliably predicts outcomes for heart failure patients could lead to new diagnostics and treatments for COVID-19 patients as well, according to newly published research from cardiologists at the University of Alberta.
A replicating RNA vaccine, formulated with a lipid-based nanoparticle emulsion that goes by the acronym LION, produces antibodies against the COVID-19 coronavirus in mice and primates with a single immunization. These antibodies potently neutralize the virus.
The effects occurred within two weeks after administration through injection into a muscle. The level of antibodies generated was comparable to those in people who are recovering from COVID-19.
Scientists report a change in why men seek help for sexual problems, with fewer men complaining about impotence (erectile dysfunction) and premature ejaculation, and more men, especially younger men, complaining about low sexual desire and curvature of the penis (Peyronie's disease).
Presenting the work at the European Association of Urology (virtual) Congress, after recent acceptance for publication, research leader Dr Paolo Capogrosso (San Raffaele Hospital, Milan, Italy) said: