People with type 2 diabetes who intensively controlled their blood sugar level during the landmark Action to Control Cardiovascular Risk in Diabetes (ACCORD) Trial Eye Study were found to have cut their risk of diabetic retinopathy in half in a follow-up analysis conducted four years after stopping intensive therapy. Investigators who led the ACCORD Follow-on Eye Study (ACCORDION) announced the results today in New Orleans at the American Diabetes Association annual meeting. The study was supported by the National Institutes of Health's National Eye Institute (NEI).
Body
In a randomized Phase III study of the drug inotuzumab ozogamicin, a statistically significant percentage of patients with acute lymphoblastic leukemia (ALL) whose disease had relapsed following standard therapies, qualified for stem cell transplants.
Inotuzumab ozogamicin, also known as CMC-544, links an antibody that targets CD22, a protein found on the surface of more than 90 percent of ALL cells. Once the drug connects to CD22, the ALL cell draws it inside and dies.
The research article - Targeting the PI3K/AKT/mTOR Pathway in Prostate Cancer Development and Progression: Insight to Therapy, by Dr Claudio Festuccia (University of L'Aquila, Italy) and published in Clinical Cancer Drugs, volume 3, issue 1 - discusses experimental and clinical data on the pharmacological inhibition of the Akt/mTOR pathways. These pathways play a key role in the modulation of cellular proliferation, tumor growth and survival through phosphorylation of different downstream molecules.
DENVER - The old adage "you are what you eat," may be better phrased as "your sleep relates to what you eat." An individual's body composition and caloric intake can influence time spent in specific sleep stages, according to results of a new study (abstract 0088) from researchers at the Perelman School of Medicine at the University of Pennsylvania that will be presented at SLEEP 2016, the 30th annual meeting of the Associated Professional Sleep Societies LLC.
Northwestern Medicine and University of Wisconsin-Madison (UW) scientists have identified a gene that causes severe glaucoma in children. The finding, published in The Journal of Clinical Investigation, validates a similar discovery made by the scientists in mice two years ago and suggests a target for future therapies to treat the devastating eye disease that currently has no cure.
DARIEN, IL - A new study sheds light on the prevalence of insomnia symptoms among female veterans.
Results demonstrate that more than 47 percent of female veterans reported symptoms of insomnia that resulted in functional impairment. Of this sample group, less than one percent had a diagnosis of a sleep disorder based on medical records.
A team of physicists that visualized the internal nanostructure of an intact butterfly wing has discovered two physical attributes that make those structures so bright and colorful.
A new atlas of light pollution documents the degree to which the world is illuminated by artificial skyglow. In addition to being a scourge for astronomers, bright nights also affect nocturnal organisms and the ecosystems in which they live. The "New World Atlas of Artificial Night Sky Brightness" was published in the open access journal Science Advances on June 10, 2016.
Prostate cancer patients may soon have a new option to treat their disease: laser heat. UCLA researchers have found that focal laser ablation - the precise application of heat via laser to a tumor - is both feasible and safe in men with intermediate risk prostate cancer.
Introducing peanut-containing foods during infancy as a peanut allergy prevention strategy does not compromise the duration of breastfeeding or affect children's growth and nutritional intakes, new findings show. The work, funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, is published online on June 10 in the Journal of Allergy and Clinical Immunology.
A workplace outcome study published in The Journal of Occupational and Environmental Medicine (JOEM) found that offices equipped with alcohol-based hand sanitizers and hand sanitizing wipes throughout the building and at employees' desks resulted in 24.3 percent fewer healthcare claims for hand hygiene preventable illnesses -- such as cold, flu and respiratory illnesses -- than the office and employees in the control group without th
The nematode species Dirofilaria repens and Dirofilaria immitis, previously endemic to Southern and Eastern Europe, are transmitted by mosquitoes primarily to canine hosts. The parasites mature inside the dogs, mate, and are passed on to the next host via mosquito vectors. "These nematodes also affect people and cats. But they are only able to reproduce in dogs, where they produce offspring that are then transmitted to mosquitoes," explains study director Hans-Peter Fuehrer of the Institute of Parasitology at Vetmeduni Vienna.
Skin deep or straight to the heart
The Basque Institute of Agricultural Research and Development Neiker-Tecnalia is currently exploring a strategy to remedy soils contaminated by organic compounds containing chlorine (organochlorine compounds). The innovative process consists of combining the application of zero-iron nanoparticles with bioremediation techniques. The companies Ekotek and Dinam, the UPV/EHU-University of the Basque Country and Gaiker-IK4 are also participating in this project known as NANOBIOR.
Coronary or peripheral bypasses are the most frequently performed vascular operations. Although one million patients per year and around the world, undergo this intervention, its failure rate reaches 50%, because of poor vessel healing, leading to vessel graft occlusion. To improve the outcome of bypasses, researchers from the University of Geneva (UNIGE) work together with medical doctors from the Lausanne University Hospital (CHUV). They developed a gel containing microparticles -'GeM', enabling the controlled release of a drug inhibiting cellular over-proliferation.
The number of species that can exist on Earth depends on how the environment changes, according to new research led by the University of Southampton.
By analysing the fossil record of microscopic aquatic creatures called planktonic foraminifera, whose fossil remains now resemble miniaturised popcorn and date back millions of years, the research provided the first statistical evidence that environmental changes put a cap on species richness.