An isolated population of honeybees, the Cape bees, living in South Africa has evolved a strategy to reproduce without males. A research team from Uppsala University has sequenced the entire genomes of a sample of Cape bees and compared them with other populations of honeybees to find out the genetic mechanisms behind their asexual reproduction.
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Scientists have won new knowledge on the molecular background of fat and energy metabolism disorders through a large-scale proteomic study with mice. The proteome is the entire set of proteins - in this case, proteins from the livers of mice. A research group specialising in proteomics, led by ETH Zurich Professor Ruedi Aebersold, and a group specialising in mitochondrial physiology and liver diseases, led by EPFL Professor Johan Auwerx, worked together on this ground-breaking project.
In today's Science, the Global Alliance for Genomics and Health (GA4GH) calls for a federated data ecosystem for sharing genomic and clinical data. The authorship, which includes Richard Durbin, Julia Wilson, Stephen Keenan, and David Lloyd of the Wellcome Trust, as well as a diverse team of international leaders in academia, research, medicine, and industry, argues that a common framework of principles, protocols, and interoperable technical systems are necessary to enable responsible and effective data sharing.
PULLMAN, Wash. - Skin cells typically spend their entire existence in one place on your body. But Washington State University researchers have seen how the cells will alter the proteins holding them in place and move to repair a wound.
"And they walk," said Jonathan Jones, director of WSU's School of Molecular Biosciences and lead author of a paper on the phenomenon in the FASEB Journal.
With a better understanding of the process behind the cell movement, scientists might be able to manipulate and enhance it so wounds heal more quickly.
CINCINNATI--Early findings by researchers at the University of Cincinnati (UC) College of Medicine suggest that the use of a second generation cancer drug, carfilzomib, may provide an improved approach for the reduction of antibodies in potential kidney transplant candidates. The research team includes members from UC Transplant Clinical Research, UC's Division of Hematology Oncology and the Cincinnati Children's Hospital Medical Center's Biomedical Informatics division.
A 3-inch monogamous hermaphrodite proves the saying "there's plenty more fish in the sea" isn't always the case.
For the tiny fish found in the coral reefs off Panama, a lifelong relationship with its partner doesn't come without some give and take. In fact, the faithful pair owe their evolutionary success to trading male and female roles: According to an April 2016 University of Florida study in the journal of Behavioral Ecology, the fish switch genders at least 20 times each day.
A special issue of the academic journal Deep-sea Research II, published recently, is devoted to expanding understanding of the global issue of chemical munitions dumped at sea.
A select group of garter snakes can thank their ancestors for the ability to chow down on a poisonous newt and live to tell the tale.
Researchers are resurrecting ancient bacterial protein complexes to determine how 3.5-billion-year-old cells functioned versus cells of today. Surprisingly, they are not that different, reports a study published June 9 in Cell Chemical Biology. Despite a popular hypothesis that primordial organisms had simple enzyme proteins, evidence suggests that bacteria around 500 million years after life began already had the sophisticated cellular machinery that exists today.
Large animals hunted for their parts--such as elephant ivory and shark fins--are in double jeopardy of extinction due to their large body size and high value, according to a new analysis reported in the Cell Press journal Current Biology on June 9. The study reveals underappreciated risk to marine species similar to that of iconic terrestrial species, but elevated by key differences in the sea.
CINCINNATI - As the promise of using regenerative stem cell therapies draws closer, a consortium of biomedical scientists reports about 30 percent of induced pluripotent stem cells they analyzed from 10 research institutions were genetically unstable and not safe for clinical use.
Failure of an enzyme to break down DNA spilling into the bloodstream as cells die may be a major driver of inflammation in lupus. This is the finding of a study in both mice and human patients led by researchers at NYU Langone Medical Center and published online June 9 in the journal Cell.
Researchers at Columbia University's Mailman School of Public Health and Columbia University Medical Center, and NewYork-Presbyterian, found that patients who did not adhere to their medication schedule for chronic conditions, such as hypertension, diabetes, and thyroid disease, prior to a breast cancer diagnosis were twice as likely to skip oral adjuvant hormonal therapy.
An estimated more than 72,000 cases of unrepaired cleft lip and/or palate exist in 28 of India's 29 states and poor states with less health infrastructure had higher rates, according to an article published online by JAMA Facial Plastic Surgery.
Published in JAMA Oncology, Principal Investigator of Vall d´Hebron Institute of Oncology´s (VHIO) Translational Genomics Group, Team Leader of translational genomics and targeted therapeutics in solid tumors at the August Pi I Sunyer Biomedical Research Institute (IDIBAPS), and Head of Medical Oncology at the Hospital Clínic in Barcelona, Aleix Prat has led a study showing the intrinsic subtyping of breast cancer by means of a genomic test as the most important prognostic factor in advanced or metastatic hormone-sensitive breast cancer.