Body

Sophia Antipolis, 24 March 2019: Fathers-to-be who smoke may increase the risk of congenital heart defects in their offspring, according to a study published today in the European Journal of Preventive Cardiology, a journal of the European Society of Cardiology (ESC). For mothers-to-be, both smoking and exposure to secondhand smoke were detrimental.

NEW ORLEANS--Treating women who have thyroid antibodies, but normal thyroid function, with a medicine called Levothyroxine does not make them more likely to deliver a live baby, new research from the United Kingdom suggests. The research will be presented Saturday, March 23 at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La., and published in The New England Journal of Medicine.

NEW ORLEANS--In recent years, women who start taking bisphosphonates (BPs) to treat osteoporosis and prevent fracture have trended from younger to older and from having osteopenia to having osteoporosis, researchers report. The results of the study will be presented on Saturday at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La.

NEW ORLEANS--Obesity may play a role in reproductive problems in women with type 1 diabetes, according to a new study to be presented Saturday, March 23 at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La.

Earlier studies have shown that type 1 diabetes is associated with menstrual irregularities and lower rates of fertility.

NEW ORLEANS--Eating later in the day may contribute to weight gain, according to a new study to be presented Saturday at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La.

Previous studies have suggested that later timing of eating and sleeping are related to obesity, said lead author Adnin Zaman, M.D., of the University of Colorado in Denver, Colo. "However, few studies have assessed both meal and sleep timing in adults with obesity, and it is not clear whether eating later in the day is associated with shorter sleep duration or higher body fat," she said.

Current treatments for tuberculosis (TB) are very effective in controlling TB infection caused by Mycobacterium tuberculosis (Mtb). They don't, however, always prevent reinfection. Why this happens is one of the long-standing questions in TB research.

New research from Washington University in St. Louis explains the cellular processes that allow a sun-loving microbe to "eat" electricity -- transferring electrons to fix carbon dioxide to fuel its growth.

In what is believed to be a first-of-its-kind systematic look at pregnancy frequency and outcomes among imprisoned U.S. women, researchers from Johns Hopkins Medicine say almost 1,400 pregnant women were admitted to 22 U.S. state and all federal prisons in a recent year. They also found that most of the prison pregnancies -- over 90 percent -- ended in live births with no maternal deaths.

Pain relief and end of life care is not being provided equally to people with advanced progressive diseases who were at home during their last three months of life, according to a study of 43,000 people who died across England.

The data for the study was drawn from responses to the National Bereavement Survey (VOICES) in England between 2011 and 2015, which asks families or close relatives to reflect on the quality of care provided to a person who has died.

FINDINGS

Researchers from UCLA's Jonsson Comprehensive Cancer Center have identified a possible new therapeutic strategy using two types of drug inhibitors at once to treat one of the world's deadliest cancers. The combination approach uses one drug that inhibits the process -- known as lysosome -- that allows cancer cells to recycle essential nutrients to survive, and another drug that blocks the pathway used to repair DNA. Researchers found the approach to be promising after testing it on pancreatic cancer cells and mice in the laboratory.

BACKGROUND

Individuals with a history of infection had a two-fold increased risk of developing Sjögren's syndrome in a Journal of Internal Medicine study. Respiratory, skin, and urogenital infections were most prominently associated with this increased risk.

Combining medications that suppress the immune system has been successful in treating young patients with Crohn's disease, but some physicians have been reluctant to use this strategy in older patients because of concerns about safety. Now an Alimentary Pharmacology & Therapeutics study indicates that older patients can be safely and effectively treated with such combined immunosuppression as well.

Several previous studies have demonstrated that moderate alcohol consumption is linked with less severe disease and better quality of life in patients with rheumatoid arthritis, but a new Arthritis Care & Research study suggests that this might not be because drinking alcohol is beneficial.

OAK BROOK, Ill. - The use of digital breast tomosynthesis (DBT), also known as 3-D mammography, may significantly reduce the number of women who undergo breast biopsy for a non-cancerous lesion following an abnormal mammogram, according to a new study published in the journal Radiology.

Unlike standard or full-field digital mammography (FFDM), which captures two x-ray images of the breast from top-to-bottom and from side-to-side, DBT captures multiple images from different angles that are synthesized into 3-D images by a computer.

OAK BROOK, Ill. - Fewer women are assigned to a dense breast category when evaluated with advanced mammographic screening technologies compared to standard digital mammography, according to a new study published in the journal Radiology.