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Researchers at the University of Eastern Finland and Kuopio University Hospital have discovered several new biomarkers that are associated with incident heart failure. In a new study, several inflammatory biomarkers and cell energy metabolites were linked to an increased risk of incident heart failure.
AURORA, Colo. (Dec. 15, 2020) - Researchers at the University of Colorado Anschutz Medical Campus have discovered that fructose stimulates the release of vasopressin, a hormone linked to obesity and diabetes. They also found that water can suppress the hormone and alleviate these conditions in mice.
In the search for new ways to treat the incurable eye disease glaucoma, researchers at Karolinska Institutet and St. Erik Eye Hospital in Sweden have discovered more clues as to its pathogenesis. A new study shows how metabolic disturbance of the neurons coincide with raised pressure in the eye. In animal and cell models, rapamycin and pyruvate treatments were shown to have a protective effect. The study is published in the journal PNAS.
Scientists have shown for the first time that cerebral malaria causes death in adults by triggering oxygen-deprivation in the brain, in new research published in Clinical Infectious Diseases.
Already available treatments, such as hypothermia, may slow brain oxygen-deprivation in cerebral malaria patients. The researchers say these neuronal survival-enhancing approaches could soon be trialled in adults with cerebral malaria, alongside existing anti-malarial treatments, to hopefully improve survival.
JUPITER, Fla. --Dec. 14, 2020--Imagine trying to throw a bullseye when the dartboard lies buried within a crumpled box. That's the challenge faced by scientists working to make new medicines for some "undruggable" diseases, including a type of metastatic breast cancer.
Scientists refer to diseases as "undruggable" when their targets lie on a protein molecule that folds inward, or in a way that shields the active site from would-be treatments.
Since the beginning of the COVID-19 pandemic, there have been reports in the professional literature on possible hearing loss caused by the disease. A new study from Tel Aviv University (TAU), in collaboration with the Galilee Medical Center, finds no evidence of damage to the auditory system as a result of COVID-19 infection.
The study was led by Professor Karen Avraham of TAU's Sackler Faculty of Medicine. The results were published online in the journal Otology & Neurotology on December 8, 2020.
Due to the COVID 19 pandemic and the associated intensive search for therapeutics and vaccines, the chemical substance class of nucleosides is experiencing an enormous increase in interest. Natural and synthetic nucleosides have an antiviral effect and can act as building blocks of ribonucleic acids (RNA). When incorporated into RNA, novel interactions within the macromolecule result with positive consequences for stability and biological effectiveness.
Almost a year ago, COVID-19 began its global rampage, going on to infect about 69.5 million people and kill about 1.6 million as of early this month. From the beginning, most scientists have said that COVID-19 is deadlier than the seasonal flu, while fringe theories have circulated widely, suggesting it is less deadly or flu's equal.
Evidence is accumulating, however, to show just how much deadlier COVID-19 is compared with the flu and the extent of complications related to the two illnesses.
A new paper released by Columbia University Mailman School of Public Health reports a strong association between a high number of adverse childhood experiences (ACEs) and contact with the U.S. justice system. Analyzing data from eleven studies, the researchers found that results were consistent across multiple types of justice system contact and across diverse geographic regions of the country. The findings are published in Pediatrics.
Researchers have developed a way to use a simple home aroma diffuser to test whether N95 and other types of sealing masks, such as KN95 and FFP2 masks, are properly fitted, a result which could be used to help protect healthcare workers and the public from contracting or transmitting COVID-19.
Southampton-led research has shown that implementing point-of-care testing in hospitals to diagnose influenza can lead to better treatment and faster recovery for patients. The researchers are now calling for routine use of these tests to become standard for patients admitted with acute respiratory symptoms during the influenza season.
LOS ANGELES -- Scientists have long known that therapies that target the cancer-driving MAPK pathway are only effective in a handful of cancers with specific mutations in a cancer gene called BRAF, and these cancers that initially respond to the therapy often end up developing resistance to the treatment, resulting in relapse for many patients.
DALLAS - Dec. 14, 2020 - Recently published UT Southwestern research reveals new insights about risk factors for depression based on data from a landmark longitudinal study focused on heart disease.
PHILADELPHIA (December 14, 2020) - National efforts to develop a coronavirus disease 2019 (COVID-19) vaccine at "warp speed" will likely yield a safe and effective vaccine by early 2021. However, this important milestone is only the first step in an equally important challenge: getting a majority of the U.S. public vaccinated.
RICHMOND, Va. (Dec. 14, 2020) -- The first COVID-19 vaccine has received emergency use authorization. Yet a key question remains: Will U.S. adults be willing to get it?
A new study led by a Virginia Commonwealth University professor is among the first to examine the psychological and social predictors of U.S. adults' willingness to get a future COVID-19 vaccine and whether these predictors differ under an emergency use authorization release of the vaccine.