ANN ARBOR, Mich. -- You wouldn't think that two Turkish children, some yeast and a bunch of Hungarian fruit flies could teach scientists much.
But in fact, that unlikely combination has just helped an international team make a key discovery about how the brain's "garbage disposal" process works -- and how little needs to go wrong in order for it to break down.
The findings show just how important a cell-cleanup process called autophagy is to our brains. It also demonstrates how even the tiniest genetic change can have profound effects on such an essential function.