Body

Penn researchers find similar outcomes for patients with severe aortic stenosis who undergo transcatheter aortic valve replaceme

CHICAGO - Nearly 1.5 million Americans have aortic stenosis (AS), the narrowing of the aortic valve opening which restricts blood flow to the aorta. Historically, patients have been treated with open-heart surgery, although recent research has suggested that transcatheter aortic valve replacement (TAVR) may be a better, less invasive treatment option for some high-risk patients.

New procedure could improve success rate of cell transplant to cure type 1 diabetes

Boston, MA-- New research suggests pretreating cells with a peptide hormone may improve the success rate of pancreatic islet cell transplants, a procedure that holds great promise for curing Type 1 diabetes. The results will be presented Saturday, April 2, at the Endocrine Society's annual meeting, ENDO 2016, in Boston.

Rates of death and stroke equivalent for surgery and TAVR at 2 years

Intermediate-risk patients with severe aortic stenosis who receive minimally invasive transcatheter aortic valve replacement, known as TAVR, have similar rates of death and disabling strokes after two years compared with those undergoing standard open heart surgical replacement, according to a study presented at the American College of Cardiology's 65th Annual Scientific Session. Patients receiving TAVR also experienced shorter hospital stays and lower incidence of some major complications compared with those undergoing surgery.

Common flame retardant chemical disrupts a hormone that is essential to life

Boston, MA-- Brominated fire retardants, used in many consumer products and known to cause hormonal irregularities, overstimulates an adrenal gland hormone in a way that may lead to the development of cardiovascular disease, new research in human cells finds. Researchers will present their study results Saturday at the Endocrine Society's 98th annual meeting in Boston.

Anabolic steroid abuse is associated with increased systolic hypertension risk

Boston, MA-- Anabolic androgenic steroid (AAS) abuse is associated with severe blood pressure (BP) increase and hypertension, new research reports. The results of the study will be presented in a poster Saturday, April 2, at ENDO 2016, the annual meeting of the Endocrine Society, in Boston.

Daytime and nighttime blood pressures were considerably higher among ongoing AAS abusers than among former abusers and non-users, and most ongoing abusers had hypertension during the night.

Pituitary insufficiency is prevalent after blast concussion in military veterans

Boston, MA-- A study in military veterans finds that explosive blast-related concussions frequently result in hormone changes leading to problems such as sleep disturbances, fatigue, depression and poor quality of life. The research, to be presented Saturday at the Endocrine Society's 98th annual meeting in Boston, evaluated hormone levels in 41 male veterans who had been deployed to Iraq or Afghanistan.

Study supports broader use of statins in intermediate-risk populations

Lowering cholesterol with statins significantly reduced adverse cardiovascular events in people with average cholesterol and blood pressure levels who were considered to be at intermediate risk for heart disease, while the use of blood pressure-lowering medications was beneficial only in those with higher blood pressure levels, according to three separate reports from the large HOPE-3 trial presented at the American College of Cardiology's 65th Annual Scientific Session.

In some men, taking testosterone while dieting may help lose fat, not muscle

Boston, MA-- In obese middle-aged men, losing weight while dieting normally depletes both fat and muscle. But adding testosterone treatment may help them lose only fat and retain their muscle, new research suggests. The study results will be presented in a poster Saturday, April 2, at ENDO 2016, the annual meeting of the Endocrine Society, in Boston.

SSRI antidepressants promote bone loss during lactation

Boston, MA-- Antidepressant use with selective serotonin reuptake inhibitors (SSRIs) during pregnancy and breast-feeding causes decreased bone density in mothers that may put them at higher risk of broken bones later in life, a new study suggests. Researchers will present the results of their animal study Friday at the Endocrine Society's 98th annual meeting in Boston.

Aromatase inhibitors plus growth hormone may help short adolescent boys grow taller

Boston, MA-- Aromatase inhibitors, when used for up to three years in combination with growth hormone, may effectively and safely help very short adolescent boys grow taller, new research suggests. The study results will be presented Sunday, April 3, at ENDO 2016, the annual meeting of the Endocrine Society in Boston.

Bone density lower with use of ADHD stimulant medicine

Boston, MA-- Children and teenagers who take stimulant drugs to treat attention-deficit hyperactivity disorder (ADHD) may have lower bone density than their peers who do not take these medications, a new study finds. The study results will be presented Friday at the Endocrine Society's 98th annual meeting in Boston.

Stimulants, such as methylphenidate (Ritalin and other brands) and amphetamine, are frequently a treatment of ADHD, a condition that affects more than 6 million children in the United States, according to the Centers for Disease Control and Prevention (CDC).

Early childhood antibiotics may change gut microbes and lead to adolescent prediabetes

Boston, MA-- Young children who take antibiotics may disrupt their gut's microbial ecosystem and be more likely to develop prediabetes in adolescence, new research from Greece reports. The study results will be presented in a poster Sunday, April 3, at ENDO 2016, the annual meeting of the Endocrine Society, in Boston.

Penn researchers find transcatheter aortic valve replacement better for patients with severe aortic stenosis

CHICAGO - Aortic stenosis (AS), the narrowing of the aortic valve opening which restricts blood flow to the aorta, afflicts nearly 1.5 million people in the United States, with approximately 500,000 of them suffering severe aortic stenosis. While open-heart surgery has historically been the recommended treatment for AS, some patients at high or extreme risk are not considered good candidates.

International technology-based competition associated with more exercise

CHICAGO (April 3, 2016) -- A competition that used technology to encourage and track physical activity was effective at helping participants lose weight and exercise more in both developed and developing countries, according to a study presented at the American College of Cardiology's 65th Annual Scientific Session.

Icahn School of Medicine at Mount Sinai to present findings at ACC

Researchers from the Icahn School of Medicine at Mount Sinai will present their Late-Breaking Clinical Trial findings and other important research results advancing the field of cardiovascular medicine at the American College of Cardiology's (ACC) 65th Annual Scientific Session and Expo in Chicago, from April 2 to 4. Mount Sinai Heart is ranked No. 7 in the nation by U.S. News & World Report in its 2015 "Best Hospitals" issue.

The new findings advance our scientific knowledge of: