Female cancer patients of reproductive age could preserve their fertility during radiation and chemotherapy through treatments that target the DNA damage response in oocytes (the cells that develop into eggs), an approach that works in animal models.
Jackson Laboratory Assistant Professor Ewelina Bolcun-Filas, Ph.D., and Terri L. Woodward, M.D., assistant professor at the University of Texas MD Anderson Cancer Center, describe the method in "Prolonging Reproductive Life after Cancer: The Need for Fertoprotective Therapies," an opinion article in Cell Press Trends in Cancer.