Howard Hughes Medical Institute scientists have designed a potential cancer therapy that uses a unique strategy to block mTOR, a molecule that helps drive the growth of many tumors. In animal experiments, the drug reduces the size of tumors that are resistant to earlier-generation mTOR inhibitors.
The work, reported May 18, 2016, in the journal Nature, was led by HHMI investigator Kevan Shokat at the University of California, San Francisco and Neal Rosen at Memorial Sloan Kettering Cancer Center.