Body

San Diego, Calif. - An emerging cancer therapy has colorectal tumors surrounded. Presenters at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) are unveiling a novel radioimmunotherapy that combines a cancer-seeking antibody with potent radionuclide agents, resulting in complete remission of colorectal cancer in mouse models.

Theranostic drugs are powerful newcomers in oncology's arsenal. In addition to providing targeted treatment, in many cases they double as imaging agents that can monitor the effectiveness of therapy.

San Diego, Calif. - Malignant neuroendocrine tumors (NETs) are relatively rare, notoriously difficult to treat, and associated with poor long-term survival. According to research presented at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI), an investigative blood test could predict how patients will respond to peptide receptor radionuclide therapy (PRRT) before they commit to a course of treatment.

TUCSON, Ariz. - Sixty-five is the age when many people retire, kick back and take it easy. And so it often is with the human immune system.

After years of fending off influenza and other infectious diseases, the immune system gradually starts to lose its oomph for fighting infection. As a result, viruses, bacteria and other microbial intruders are a common killer of adults 65 and older.

RICHLAND, Wash. - After their nanorods were accidentally created when an experiment didn't go as planned, the researchers gave the microscopic, unplanned spawns of science a closer look.

Chemist Satish Nune was inspecting the solid, carbon-rich nanorods with a vapor analysis instrument when he noticed the nanorods mysteriously lost weight as humidity increased. Thinking the instrument had malfunctioned, Nune and his colleagues moved on to another tool, a high-powered microscope.

When a molecule emits a blink of light, it doesn't expect it to ever come back. However researchers have now managed to place single molecules in such a tiny optical cavity that emitted photons, or particles of light, return to the molecule before they have properly left. The energy oscillates back and forth between light and molecule, resulting in a complete mixing of the two.

Columbus, Ohio - A new study suggests that blocking an enzyme called PRMT5 in tumor cells could be a promising new strategy for the treatment of glioblastoma (GB), the most aggressive and lethal form of brain cancer.

The study by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) shows that knocking down PRMT5 (protein arginine methyltransferase 5) might force the cells into senescence and slow or stop tumor growth.

Pain-relieving prescription opioids are the subject of a new original investigation and research letter published online by JAMA Internal Medicine.

In the original investigation, Anupam B. Jena, M.D., Ph.D., of Harvard Medical School, Boston, and coauthors analyzed pharmacy claims from a 20 percent random sample of Medicare beneficiaries in 2011 to estimate the frequency of opioid prescribing at hospital discharge among those patients who did not have an opioid prescription 60 days prior to hospitalization.

Breastfeeding in children who had received no antibiotics before weaning was associated with a decreased number of antibiotic courses after weaning and a decreased body mass index (BMI) later in childhood, according to an article published online by JAMA Pediatrics.

One of the major obstacles with treating cancer is that tumors can conscript the body's immune cells and make them work for them. Researchers at EPFL have now found a way to reclaim the corrupted immune cells, turn them into signals for the immune system to attack the tumor, and even prevent metastasis.

CANCER RESEARCH UK scientists have found a new way to slow the growth of the most aggressive type of breast cancer, according to research published in the journal Oncogene* today (Monday).

The team from Oxford University and the University of Nottingham found that using a drug called JQ1 can alter how cancer cells respond to hypoxia -- or low oxygen -- found in more than 50 per cent of breast tumours overall and most commonly in triple negative breast cancer, the form of the disease that is hardest to treat.

Irvine, Calif. -- The Botox toxin has a sweet tooth, and it's this craving for sugars - glycans, to be exact - that underlies its extreme ability target neuron cells in the body ... while giving researchers an approach to neutralize it.

UPTON, NY--A cube, an octahedron, a prism--these are among the polyhedral structures, or frames, made of DNA that scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory have designed to connect nanoparticles into a variety of precisely structured three-dimensional (3D) lattices. The scientists also developed a method to integrate nanoparticles and DNA frames into interconnecting modules, expanding the diversity of possible structures.

The science of breeding chickens has revealed part of the mystery of how certain female animals are able to store sperm long-term. Droplets of fat transferred from female cells to sperm cells may contribute to keeping sperm alive.

Females of some types of insects, reptiles, and birds can store sperm from multiple males within specialized sperm storage areas of their reproductive tracts. Different animals can store sperm for days or years. Stored sperm can fertilize multiple eggs over time, meaning females do not need to mate again to fertilize additional eggs.

Despite recent progress, the organization and ecological properties of the intestinal microbial ecosystem remain under investigated. Using a manually curated metabolic module framework for (meta-)genomic data analysis, Sara Vieira-Silva, Gwen Falony and colleagues from the Jeroen Raes lab (VIB/KU Leuven) studied species-function relationships in gut microbial genomes and microbiomes.

Amsterdam, June 13, 2016 - Tiny molecular scaffolding that joins molecules together could be the key to our battle against antibiotic resistance. Research published in Bioorganic & Medicinal Chemistry Letters shows that carbon nanodot scaffolding assembled with small molecules called polyamines can kill some dangerous drug-resistant bacteria, including Acinetobacter baumanii and Klebsiella pneumonia.