It is now possible to predict who the best candidate for receiving an organ transplant is, know whether clients of a bank will return the loans they request, choose the films that best coincide with the interests of consumers or even select someone's ideal partner. Mathematical algorithms constantly analyse millions of items of data, identify patterns and make predictions about all areas of life. But in most cases, the results give little more than a closed prediction that cannot be interpreted and which is often affected by biases in the original data.
Characterization of unique PMEPA1 gene splice variants (isoforms d and e) from RNA Seq profiling pro
The cover for issue 4 of Oncotarget features Figure 8, "Model for biological function categorization of PMEPA1 isoforms (c, d, and e) in the context of prostate cancer," by Sharad, et al.
31 January 2020, Cambridge - Researchers at EMBL's European Bioinformatics Institute (EMBL-EBI) and Queen Mary University of London have led a study to categorise which genes are essential for supporting life. The results from this study could be a useful new resource to help researchers identify mutations responsible for rare childhood diseases.
CHAMPAIGN, Ill. -- Artificial sweeteners such as sucralose provide the seductive taste of sweetness without the calories contained in sugar - a seeming win-win for people who need to control their blood sugar and insulin levels or weight.
However, simply tasting or consuming sucralose may affect blood glucose and insulin levels on glucose tolerance tests, scientists at the University of Illinois found in a new study.
Antiretroviral drugs are the gold standard for the treatment of HIV infection. They are highly effective in suppressing replication of the virus but require lifelong daily application and can be associated with side effects. Due to the high mutability of HIV and its capacity for rapid adaptation, combinations of antiretroviral agents are required to prevent the development of drug re-sistance and treatment failure.
Broadly neutralizing antibodies targeting HIV
On January 24, 2020, the French Ministry of Health confirmed the first three cases of patients affected by the Wuhan coronavirus. On January 29, 2020, the Institut Pasteur, which is responsible for monitoring respiratory viruses in France, sequenced the whole genome of the coronavirus known as "2019-nCoV", becoming the first institution in Europe to sequence the virus since the start of the outbreak.
Intratumoral injection of SD-101 induces significant anti-tumor immunity in preclinical and clinical studies, especially when combined with PD-1 blockade.
As well as sequencing the whole genome of coronavirus 2019-nCoV, the Institut Pasteur continued to work on the samples taken from the first confirmed cases. The quality of these initial samples enabled rapid cell-culture isolation of the new virus. The Institut Pasteur's scientists now have access to the virus responsible for the infection. The isolation of the virus paves the way for new diagnostic, therapeutic and prophylactic approaches.
Adults living with HIV in Washington, D.C., were more likely to feel higher levels of emotional and physical well-being if they attended religious services regularly, prayed daily, felt "God's presence," and self-identified as religious or spiritual, according to research published online Jan. 29, 2020, in Psychology of Religion and Spirituality. By contrast, patients living with HIV who had the lowest levels of quality of life and more mental health challenges were privately religious, potentially eschewing organized religion due to fears about being stigmatized or ostracized.
Physicists at Washington University in St. Louis have proposed a way to use data from ultra-high energy neutrinos to study interactions beyond the standard model of particle physics. The 'Zee burst' model leverages new data from large neutrino telescopes such as the IceCube Neutrino Observatory in Antarctica and its future extensions.