Researchers from the Max Planck Institute for Terrestrial Microbiology in Marburg have described a previously unrecognized mechanism of bacterial transcriptional regulation that is obviously widespread in bacteria. In the future, their findings could also help fight antibiotic resistance.
Despite being considered as one of the best studied spiders in the Palearctic, the orb-weaver spiders (family Araneidae) remain poorly known in the central parts of the ecozone. To bridge the knowledge gaps, an international research team of researchers took to the Caucasus, Middle East and Central Asia to study two of those genera: Araniella and Neoscona.
The research - which was undertaken at the University of York - also suggests there was no single point of origin for the world's oldest pottery.
Academics extracted and analysed ancient fats and lipids that had been preserved in pieces of ancient pottery - found at a number of sites on the Amur River in Russia - whose dates ranged between 16,000 and 12,000 years ago.
A genetic mutation that disrupts how DNA sends messages to the rest of a cell has been linked to a large number of blood cancers. Thanks to a collaboration between biologists at Cold Spring Harbor Laboratory (CSHL) and an oncologist at Memorial Sloan Kettering Cancer Center (MSKCC), we now know how the mutation triggers a chain of biological events that lead to most leukemias.
Cleveland Clinic researchers have identified for the first time an explanation of why patients with identical PTEN mutations often have vastly different clinical presentations.
In a new study published in JAMA Network Open, a team of researchers led by Charis Eng, MD, PhD, of Cleveland Clinic Lerner Research Institute's Genomic Medicine Institute, discovered that copy number variations (CNVs) may act as genomic modifiers that influence the risk of autism spectrum disorder (ASD) and/or developmental delay (DD) versus cancer risk in individuals with PTEN mutations.
University of Groningen physicists have visualized hydrogen at the titanium/titanium hydride interface using a transmission electron microscope. Using a new technique, they succeeded in visualizing both the metal and the hydrogen atoms in a single image, allowing them to test different theoretical models that describe the interface structure. The results were published on 31 January in the journal Science Advances.
T cells play a huge role in our immune system's fight against modified cells in the body that can develop into cancer. Phagocytes and B cells identify changes in these cells and activate the T cells, which then start a full-blown program of destruction. This functions well in many cases - unless the cancer cells mutate and develop a kind of camouflage that let them escape the immune system undetected. Researchers at the University of Freiburg and the Leibniz University Hannover (LUH) have now described how a key protein in this process known as "immune escape" becomes activated.
A year-by-year age analysis of colorectal cancer rates among U.S. adults finds a 46% increase in new diagnoses from ages 49 to 50, indicating that many latent cases of the disease are likely going undiagnosed until routine screenings begin at 50, according to a new study in JAMA Network Open.
CHICAGO (January 31, 2020): Virtual antibody crossmatching is a safe and efficient way of selecting kidney transplant recipients. Two years after implementing the process, the Medical University of South Carolina (MUSC) division of transplant surgery, Charleston, concluded that the technique was just as accurate and sensitive as physical crossmatch, the current gold standard, and much quicker.
It's not an over-the-counter drug, but naloxone can now be dispensed by a pharmacist without a prescription in some states. Researchers have found it's made a huge impact on the number of prescriptions being dispensed in Ohio.