Biophysicists from the Moscow Institute of Physics and Technology and the University of Groningen in the Netherlands have visualized a nearly complete transport cycle of the mammalian glutamate transporter homologue from archaea. They confirmed that the transport mechanism resembles that of an elevator: A "door" opens, ions and substrate molecules come in, the door closes, and they travel through the membrane.
The April 18 special issue of Advances in Atmospheric Sciences, titled, "Antarctic Meteorology and Climate: Past, Present and Future," presents the latest findings from expanded and ongoing research efforts in Antarctic meteorology, weather prediction, climate variability and climate change.
A team of scientists led by the University of Michigan Rogel Cancer Center and Case Comprehensive Cancer Center has identified the binding site where drug compounds could activate a key braking mechanism against the runaway growth of many types of cancer.
The discovery marks a critical step toward developing a potential new class of anti-cancer drugs that enhance the activity of a prevalent family of tumor suppressor proteins, the authors say.
The findings, which appear in the leading life sciences journal Cell, are less a story of what than how.
An immunological test known as a "tetramer assay" can detect and quantify the T cells in a blood sample that are able to recognize a specific antigen, such as a viral protein. Making the molecular probes needed for this type of assay, however, has always been a difficult and time-consuming process.
Genetic research throughout Europe shows evidence of drastic population changes near the end of the Neolithic period, as shown by the arrival of ancestry related to pastoralists from the Pontic-Caspian steppe. But the timing of this change and the arrival and mixture process of these peoples, particularly in Central Europe, is little understood. In a new study published in Nature Communications, researchers analyze 96 ancient genomes, providing new insights into the ancestry of modern Europeans.
Scientists sequence almost one hundred ancient genomes from Switzerland
AMHERST, Mass. - Only 10 years ago, scientists working on what they hoped would open a new frontier of neuromorphic computing could only dream of a device using miniature tools called memristors that would function/operate like real brain synapses.
Multiple sclerosis (MS) is known as "the disease with a thousand faces" because symptoms and progression can vary dramatically from patient to patient. But every MS patient has one thing in common: Cells of their body's own immune system migrate to the brain, where they destroy the myelin sheath - the protective outer layer of the nerve fibers. As a result, an electrical short circuit occurs, which prevents the nerve signals from being transmitted properly.
Many MS medications impair immune memory
Engineers at the McKelvey School of Engineering at Washington University in St. Louis have received federal funding for a rapid COVID-19 test using a newly developed technology.
Srikanth Singamaneni, professor of mechanical engineering and materials science, and his team have developed a rapid, highly sensitive and accurate biosensor based on an ultrabright fluorescent nanoprobe, which has the potential to be broadly deployed.
LA JOLLA--A new study co-led by scientists at the La Jolla Institute for Immunology (LJI) adds increasing evidence that Parkinson's disease is partly an autoimmune disease. In fact, the researchers report that signs of autoimmunity can appear in Parkinson's disease patients years before their official diagnosis.
The research could make it possible to someday detect Parkinson's disease before the onset of debilitating motor symptoms--and potentially intervene with therapies to slow the disease progression.
Overreliance on promises of new technology to solve climate change is enabling delay, say researchers from Lancaster University.
Their research published in Nature Climate Change calls for an end to a longstanding cycle of technological promises and reframed climate change targets.
Contemporary technological proposals for responding to climate change include nuclear fusion power, giant carbon sucking machines, ice-restoration using millions of wind-powered pumps, and spraying particulates in the stratosphere.