In an article about to be published in EPJ Plus, Daan Frenkel from the University of Cambridge, UK, outlines the many pitfalls associated with simulation methods such as Monte Carlo algorithms or other commonly used molecular dynamics approaches.
The context of this paper is the exponential development of computing power in the past 60 years, estimated to have increased by a factor of 1015, in line with Moore's law. Today, short simulations can reproduce a system the size of a bacterium.