Researchers have identified a gene-regulating protein in the brains of mice that triggers the animals' ability to cope with the "behavioral despair" caused by inescapable stress. They said their studies have yielded an animal model of resilience that they will use to explore how antidepressants work on the brain circuitry involved in such stress response.
Led by Eric Nestler, the researchers published their findings in the July 19, 2007, issue of the journal Neuron, published by Cell Press.