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LOS ANGELES (April 13, 2021) -- The Lundquist Institute (TLI) Investigator Dong W. Chang, MD, and his colleagues' study on critically ill patients and ICU treatments was published in JAMA Internal Medicine. The study - "Evaluation of Time-Limited Trials Among Critically Ill Patients with Advanced Medical Illnesses and Reduction of Nonbeneficial ICU Treatments" - found that training physicians to communicate with family members of critically ill patients using a structured approach, which promotes shared decision-making, improved the quality of family meetings.

Oakland, CA-In the first study to report on the health effects of exposure to a toxic environmental chemical over three human generations, a new study has found that granddaughters whose grandmothers were exposed to the pesticide DDT have higher rates of obesity and earlier first menstrual periods. This may increase the granddaughters' risk for breast cancer as well as high blood pressure, diabetes and other cardiometabolic diseases.

WINSTON-SALEM, N.C. - April 14, 2021 - Investigators at Wake Forest School of Medicine, part of Wake Forest Baptist Health, have identified a set of new genetic markers that could potentially lead to new personalized treatments for lung cancer.

The study appears online in Cancer Research, a journal of the American Association for Cancer Research.

Research by Australian scientists could pave the way to a new treatment for a currently incurable brain cancer in children called Diffuse Intrinsic Pontine Glioma, or DIPG. Affecting about 20 children in Australia each year, DIPG is a devastating disease with an average survival time of just nine months after diagnosis.

The research, led by scientists at Children's Cancer Institute and published this week in the international journal, Cell Reports, offers an exciting new therapeutic approach for the treatment of DIPG by using a new anti-cancer drug.

First study to examine suicides occurring around the world during the COVID-19 pandemic finds that - in high-income and upper-middle-income countries - suicide numbers have remained largely unchanged or have declined in the early months of the pandemic, compared with expected levels.

However, the authors stress that governments must remain vigilant as the longer-term mental health and economic effects of the pandemic unfold and be poised to respond if the situation changes.

PITTSBURGH, April 13, 2021 - Wheezing, coughing that doesn't stop, a pale and sweaty face: clinically, severe asthma attacks look very similar from patient to patient. But biologically, not all severe asthma is the same--and a team of scientists has, for the first time, identified the key difference in people, a finding that has important implications for treatment.

A new study finds that brachytherapy, a common procedure that delivers radiation directly to cancer cells, may continue safely, potentially without delay or antibiotics, in cervical cancer patients following uterine perforation.

According to the World Health Organization, cervical cancer is the fourth most common cancer in women. Treatment for cervical cancer often involves brachytherapy combined with daily radiation therapy. Brachytherapy delivers radiation directly to cancer cells through a tube placed within the uterus.

CLEVELAND, Ohio (April 14, 2021)--Despite all the advances in medicine, some basic questions remain. For example, people cannot be told with any certainty how long they'll live. Nor can it be predicted exactly when a woman's childbearing years will end. However, a new study offers insights into factors that might predict a woman's age at natural menopause. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS).

New research led by the Garvan Institute of Medical Research has revealed how breast cancer cells that develop during or after pregnancy change their environment to form more aggressive tumours.

In experimental models of pregnancy-associated breast cancer, researchers found that cancer cells send signals to the connective tissue around them to trigger uncontrolled inflammation and remodel the tissue, which in turn helps the cancer to spread.

Researchers from the group of Hans Clevers (Hubrecht Institute) developed the first patient-derived organoid model for cervical cancer. They also modelled the healthy human cervix using organoids. In close collaboration with the UMC Utrecht, Princess Máxima Center for pediatric oncology and the Netherlands Cancer Institute, the researchers used the organoid-based platform to study sexually transmitted infections for a herpes virus. The model can potentially also be used to study the human papillomavirus (HPV), which is one of the main causes of cervical cancer.

Below please find link(s) to new coronavirus-related content published today in Annals of Internal Medicine. All coronavirus-related content published in Annals of Internal Medicine is free to the public. A complete collection is available at https://annals.org/aim/pages/coronavirus-content.

April 13th, 2021, Washington, D.C. - The severe health and economic impacts of the COVID-19 pandemic have disrupted food systems and upended livelihoods. Yet pandemic responses have demonstrated the power of well-crafted policies to blunt the impact of major shocks while laying the groundwork for stronger, more resilient food systems, according to the 2021 Global Food Policy Report, released today by the International Food Policy Research Institute (IFPRI).

New research led by a professor at NUI Galway is set to change how doctors treat some patients with high blood pressure - a condition that affects more than one in four men and one in five women.

The study by researchers at NUI Galway, Johns Hopkins University and Harvard Medical School found no evidence that diastolic blood pressure - the bottom reading on a blood pressure test - can be harmful to patients when reduced to levels that were previously considered to be too low.

Cancer patients from the UK were 1.5 times more likely to die following a diagnosis with COVID-19 than cancer patients from European countries.

This is the finding of a study of over 1000 patients - 924 from European countries and 468 from the UK - during the first wave of the COVID-19 pandemic. The research team, led by Imperial College London, say the study highlights the need for UK cancer patients to be prioritised for vaccination.

Artificial intelligence could be one of the keys for limiting the spread of infection in future pandemics. In a new study, researchers at the University of Gothenburg have investigated how machine learning can be used to find effective testing methods during epidemic outbreaks, thereby helping to better control the outbreaks.

In the study, the researchers developed a method to improve testing strategies during epidemic outbreaks and with relatively limited information be able to predict which individuals offer the best potential for testing.