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R21/Matrix-M becomes the second malaria vaccine candidate ever to start a phase III licensure trial
This builds on the recent finding of high level efficacy of this vaccine in a phase IIb trial in children in Burkina Faso, published today in The Lancet
The first phase III trial doses were administered by the team at the Malaria Research and Training Centre, Bamako, Mali, one of five trial sites across West and East Africa
Sophia Antipolis, 6 May 2021: One in four heart attack patients have atypical symptoms such as breathing difficulties, extreme exhaustion, and abdominal pain, according to a study published today in European Heart Journal - Acute Cardiovascular Care, a journal of the European Society of Cardiology (ESC).1 Patients with atypical symptoms were less likely to receive emergency help and more likely to die within 30 days compared to those with chest pain.
After reviewing a database of gene mutations in children with autism spectrum disorder (ASD), a team of Medical University of South Carolina (MUSC) researchers decided to study a specific gene mutation that likely caused ASD in a girl. They demonstrated that the mutation was damaging to the gene, and that female, but not male, mice lacking a working copy of the gene also showed ASD-associated symptoms. Better understanding the interplay between genetics and sex in ASD could set the stage for developing sex-specific treatments for autism.
A recent study from the University of Helsinki monitors the breakthrough progresses in the development of microneedles for immunotherapy and discusses the challenges regarding their production. Researchers suggest using microneedles for immunotherapy due to the high abundance of immune cells under the skin. The aim is to vaccinate or treat different diseases, such as cancer and autoimmune disorders, with minimal invasiveness and side effects.
There is currently no consensus on what quality end-of-life care for children with cancer looks like, or how to measure and deliver it; however, investigators recently assembled an expert panel to help fill this void.
A large study from Denmark and Norway published by The BMJ today sheds more light on the risk of rare blood clots in adults receiving their first dose of the Oxford-AstraZeneca covid-19 vaccine.
The findings show slightly increased rates of vein blood clots including clots in the veins of the brain, compared with expected rates in the general population. However, the researchers stress that the risk of such adverse events is considered low.
Many people with diabetes endure multiple, painful finger pricks each day to measure their blood glucose. Now, researchers reporting in ACS Sensors have developed a device that can measure glucose in sweat with the touch of a fingertip, and then a personalized algorithm provides an accurate estimate of blood glucose levels.
A new service piloted at Penn Medicine allowed a proportion of patients to avoid hospitalization by providing them with greater support after visiting the emergency department. The vast majority of the patients enrolled in the service - nearly 9 out of 10 - did not need to return to the hospital for care in the month that followed their initial visit. The study was published in Healthcare.
The new Danish-Norwegian study is the first study to document possible adverse events in relation to the COVID-19 vaccine Vaxzevria? from AstraZeneca, in which all vaccine recipients have been followed systematically, as opposed to previous studies, which have relied primarily on reported adverse reactions.
The new study was a cooperation between Danish and Norwegian research institutions.
Scientists from Russia and Italy studied a new axis of the pathway that prevents the development of liver fibrosis. The role of GILZ protein in curbing the disease progression was shown in a study using mice models and confirmed by clinical data. These findings can be used in the treatment of liver fibrosis in humans. The research was published in the journal Cell Death & Disease.
New Haven, Conn. -- A Yale-led study reveals that new medicines and vaccines approved for use in the United States are often unavailable in countries that hosted their clinical trials, suggesting that the benefits of drug research are not being shared equitably among populations that participate in testing.
A new mutation found in a gene associated with an increased risk of atrial fibrillation poses a significantly increased risk for heart failure in Black people.
The discovery, made by researchers at the University of Illinois Chicago, could change current guidelines that recommend against genetic testing in people with atrial fibrillations, also known as AFib.
According to a new study published in the journal Research in Social and Administrative Pharmacy, hospitals that participate in the 340B Drug Pricing Program provide more medication access services -- which are services that help remove barriers to accessing necessary medications -- than comparably sized non-340B hospitals.
The majority of top-rated fertility apps collect and even share intimate data without the users' knowledge or permission, a collaborative study by Newcastle University and Umea University has found.
Researchers are now calling for a tightening of the categorisation of these apps by platforms to protect women from intimate and deeply personal information being exploited and sold.
University of Bristol research into octopus vision has led to a quick and easy test that helps optometrists identify people who are at greater risk of macular degeneration, the leading cause of incurable sight loss.