Body

Imagine stuffing yourself with a day's worth of food in two hours or less. Imagine feeling disgusted, depressed and guilty once you finally stop. Then imagine doing it again, repeatedly and uncontrollably, once a week or more for months on end.

Forestry access roads can have undesirable outcomes on fish populations living in remote lakes due to increased access, reveals research written by Len Hunt and Nigel Lester of the Ontario Ministry of Natural Resources, recently published in the journal North American Journal of Fisheries Management.

Choosing "greener" household cleaners, computers, and other consumer products could become as easy as reading a product's label thanks to a movement under way to develop universal guidelines for determining whether chemical products and chemical processes are environmentally friendly. That's the topic of an article in Chemical & Engineering News (C&EN), ACS' weekly newsmagazine.

CINCINNATI—An international team led by a University of Cincinnati (UC) researcher has shown how a bacterial community evolves to survive hostile host defenses in the body.

Amsterdam, 12 May 2010 – Elsevier, a world-leading publisher of scientific, technical and medical information products and services, today announced it has built a new iPhone application, Scopus Alerts (Lite) (http://tinyurl.com/scopusmob), that gives researchers mobile access to the Searching and Alerting features of Scopus, the world's largest abstract and citation database.

Results of a nationwide telephone survey have shown that the rate of peanut allergies in children more than tripled from 1997 to 2008. The data are reported in the May 12 issue of the Journal of Allergy and Clinical Immunology.

Probiotics are a group of live microorganisms administered in adequate amounts which confer a beneficial health effect on the host. This bacterial community plays a pivotal role in human nutrition and health by promoting the supply of nutrients, preventing pathogen colonization and shaping and maintaining normal mucosal immunity. While the precise mechanistic basis of the beneficial effects of probiotics is obscure and will most likely vary depending on the strain and species used.

Hepatocellular carcinoma (HCC) responds poorly to chemotherapy owing to MDR. Recent studies have shown the tumors derived from the colon, kidney, or adrenal cortex, and HCC exhibited overexpression of MDR1/P-gp. This overexpression results in a primary MDR phenotype of these cancers. Tumor derived cell lines are one of the most important tools for investigation of the biological mechanisms directly leading to drug resistance in patients.

A recent case report published on May 14, 2010 in World Journal of Gastroenterology describes the imaging features of a ruptured superior mesenteric artery aneurysm,which created a giant hematoma and mimicked a pancreatic mass, with mild dilatation of main pancreatic duct.

Duodenocaval fistula (DCF) is an uncommon but lethal clinical entity. The high mortality has been attributed to the difficulty of diagnosis before attempts at definitive therapy.

A case report and review of literature to be published on May 14, 2010 in the World Journal of Gastroenterology addresses the diagnostic significance of computed tomography (CT) and magnetic resonance imaging (MRI) for DCF.

It has so far not been proven that the long-acting insulin analogues (LAIAs) insulin detemir (trade name: Levemir) and insulin glargine (trade name: Lantus), which are approved for the treatment of type 1 diabetes, offer patients an additional benefit versus long-acting human insulin. This applies to adults as well as to children and adolescents. This is the result of the final report published by the Institute for Quality and Efficiency in Health Care (IQWiG) on 19 April 2010.

Treating serious gum disease in diabetics can help to lower their blood sugar levels, a study has shown.

Researchers have found that reducing inflammation of the gums in people with diabetes can help lower the risk of serious complications associated with the condition, such as eye problems and heart disease.

The study – led by the University of Edinburgh– analysed the findings of previous research into the link between diabetes and serious gum disease – known as periodontal disease.

The findings are published as part of the international Cochrane Collaboration.

Cholangiocarcinoma (CCA) is a malignant tumor, characterized by a poor prognosis and unresponsive to conventional chemotherapeutic agents. Therefore, searching for novel and effective therapeutic agents for CCA is necessary. In previous studies, several caged xanthones from G. hanburyi have been reported to be potent antiproliferatives as well as having anticancer and anti-tumor activities and they induce apoptosis in various cancer cell lines. However, the molecular target of these compounds remains unclear.

Diabetes mellitus is a chronic metabolic disease resulted from, either decreased production of insulin or increased resistance to it from peripheral tissues or both factors combined together. While medical treatment remains the mainstay of treatment for diabetes, some surgical procedures, such as Roux-en-Y gastric bypass, have demonstrated some potential to be a treatment option for diabetes.