Naringenin, an antioxidant derived from the bitter flavor of grapefruits and other citrus fruits, may cause the liver to break down fat while increasing insulin sensitivity, a process that naturally occurs during long periods of fasting.
Body
Use of an experimental targeted drug to treat metastatic melanoma tumors with a specific genetic signature was successful in more than 80 percent of patients in a phase 1 clinical trial. Results of the trial of PLX4032, an inhibitor of a protein called BRAF that is overactive in more than half of all melanomas, appear in the August 26 New England Journal of Medicine.
Oyster reefs are on the decline, with over-harvesting and pollution reducing some stocks as much as 98 percent over the last two centuries.
A type of high-tech imaging can be used to distinguish the foodborne pathogen Campylobacter from other microorganisms as quickly as 24 hours after a sample is placed on solid media in a Petri dish, according to a study published by U.S. Department of Agriculture (USDA) scientists.
RIVERSIDE, Calif. – Drought-tolerant crops have moved closer to becoming reality.
A collaborative team of scientists has made a significant advance on the discovery last year by the University of California, Riverside's Sean Cutler of pyrabactin, a synthetic chemical that mimics a naturally produced stress hormone in plants to help them cope with drought conditions.
PITTSBURGH, Aug. 25 – Vitamin D may be an effective therapy to treat and even prevent allergy to a common mold that can cause severe complications for patients with cystic fibrosis and asthma, according to researchers from Children's Hospital of Pittsburgh of UPMC, the University of Pittsburgh School of Medicine and Louisiana State University School of Medicine.
A collaborative team of scientists led by researchers at The Medical College of Wisconsin, in Milwaukee, has used the tools of structural biology to understand how a synthetic chemical mimics abscisic acid (ABA), a key stress hormone that helps plants cope with adverse environmental conditions such as drought. The results are published online in Nature Structural & Molecular Biology in advance of print publication later.
A unique experiment at Rice University that forces bacteria into a head-to-head competition for evolutionary dominance has yielded new insights about the way Darwinian selection plays out at the molecular level. An exacting new analysis of the experiment has revealed precisely how specific genetic mutations impart a physical edge in the competition for survival.
The new research, which could lead to more effective strategies to combat antibiotic drug resistance, was the most downloaded article this month in the journal Molecular Systems Biology.
San Francisco, California – August 25, 2010 – FibroGen, Inc., today announced results of a 2-year clinical study demonstrating that surgical implantation of biosynthetic corneas formulated with the company's proprietary recombinant human type III collagen (rhCIII) restored vision and promoted nerve regeneration (restoring sensitivity) in patients who had corneal damage and significant vision loss. The results of this phase 1, investigator-sponsored study were published today in Science Translational Medicine.1
In real estate, location is everything. The same might be said of lipids – those crucial cellular fats and oils that serve as building blocks for cells and as key energy sources for the body.
CAMBRIDGE, Mass. -- Scientists at Harvard University have sketched a new map of the "evolutionary labyrinth" species must traverse to reach eusociality, the rare but spectacularly successful social structure where individuals cooperate to raise offspring.
PHILADELPHIA –- An international study led by biologists and neuroscientists from the University of Pennsylvania has identified a new genetic risk factor for amyotrophic lateral sclerosis, commonly known as ALS or Lou Gehrig's disease.
Conrado Soria, Ph.D., a research assistant and co-first author of the study, quickly realized that E1B-55K was only half of the story. "The inability of the E1B-55K-mutant virus to replicate in normal cells was not because the virus failed to degrade p53," he explains.
New research uncovers what may be a primary neuron-damaging insult that occurs in an inherited form of a devastating neurodegenerative disorder. The study published in the journal Neuron describes a critical mechanistic link between a mutant protein and disease pathogenesis in an animal model of amyotrophic lateral sclerosis (ALS).