In a breakthrough that could lead to new treatments for patients with malignant melanoma, researchers from Mount Sinai School of Medicine have discovered that a particular protein suppresses the progression of melanoma through regulation of an oncogene, or gene responsible for cancer growth. The study is published in the December 23 issue of Nature.
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A protein implicated in the development of vascular diseases may also contribute to the failure of arteriovenous (AV) fistulas created for vascular access in dialysis patients, according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN).
"Our findings raise the possibility that monocyte chemoattractant protein-1 (MCP-1) may contribute to the relatively poor outcomes regarding the function and longevity of human hemodialysis AV fistulas," comments Karl A. Nath, MB.ChB (Mayo Clinic, Rochester, MN).
HOUSTON — People with higher levels of folate in their red blood cells were more likely to have two tumor-suppressing genes shut down by methylation, a chemical off switch for genes, researchers report in the December issue of Cancer Prevention Research.
ST. PAUL, Minn. –People living in the "stroke belt" states eat more fried fish than people living in the rest of the country, which may contribute to the high rate of death from stroke in those states, according to a study published in the December 22, 2010, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Studies have shown that the omega-3 fatty acids in fish, especially fatty fish, may reduce the risk of stroke. Research has shown that frying fish leads to the loss of the natural fatty acids.
MADISON – To survive in a tumultuous environment, sea urchins literally eat through stone, using their teeth to carve out nooks where the spiny creatures hide from predators and protect themselves from the crashing surf on the rocky shores and tide pools where they live.
CORVALLIS, Ore. – Marine ecologists at Oregon State University have shown for the first time that tiny fish larvae can drift with ocean currents and "re-seed" fish stocks significant distances away – more than 100 miles in a new study from Hawaii.
Researchers at the University of Minnesota have discovered how HIV binds to and destroys a specific human antiviral protein called APOBEC3F. The results suggest that a simple chemical change can convert APOBEC3F to a more effective antiviral agent and that shielding of a common feature shared by related proteins may yield a similar outcome.
Researchers have discovered evidence of a distinct group of "archaic" humans existing outside of Africa more than 30,000 years ago at a time when Neanderthals are thought to have dominated Europe and Asia. But genetic testing shows that members of this new group were not Neanderthals, and they interbred with the ancestors of some modern humans who are alive today.
The journal Nature reported the finding this week. The National Science Foundation's Behavioral and Cognitive Sciences Division partially funded the research.
STANFORD, Calif. — Researchers at the Stanford University School of Medicine have discovered that many cancer cells carry the seeds of their own destruction — a protein on the cell surface that signals circulating immune cells to engulf and digest them. On cancer cells, this "eat me" signal is counteracted by a separate "don't eat me" signal that was described in an earlier study. The two discoveries may lead to better cancer therapies, and also solve a mystery about why a previously reported cancer therapy is not more toxic.
FINDINGS: By determining how corticosteroids act to increase production of red blood cell progenitors, Whitehead Institute researchers have identified a class of drugs that may be beneficial in treating some erythropoietin-resistant anemias. One such anemia is Diamond-Blackfan anemia (DBA), which is frequently treated with corticosteroids, despite their severe side-effects. The identified class of drugs may be able to treat other anemias, including those resulting from trauma, sepsis, malaria, kidney dialysis, and chemotherapy.
Researchers at The Wistar Institute announce the release of an online tool that will help scientists find "gene promoters"—regions along a DNA strand that tell a cell's transcription machinery where to start reading in order to create a particular protein. The Mammalian Promoter Database (MPromDb) integrates the genome sequencing data generated at Wistar with publicly available data on human and mouse genomics. MPromDb pinpoints known promoters and predicts where new ones are likely to be found, the researchers say.
Gaithersburg, MD – On December 14-15, 2010, the U.S. Food and Drug Administration (FDA) convened an Advisory Panel to discuss several scientific issues that may affect the regulation of dental amalgam. At the conclusion of the hearing, the Panel voted to recommend that the FDA conduct further review of the material's safety.
University Park, Pa. -- A computer program that automatically analyzes mounds of satellite images and other data could help climate scientists keep track of complex, constantly changing environmental conditions, according to an international team of researchers.
CAMBRIDGE, Mass. (December 22, 2010) – Whitehead Institute researchers have linked hyperactivity in the mechanistic target of rapamycin complex 1 (mTORC1) cellular pathway, to reduced ketone production, which is a well-defined physiological trait of aging in mice.
Their results are reported in the December 23 edition of the journal Nature.