Despite a long-standing requirement for medical device makers to include women in studies they submit to the Food and Drug Administration for device approval, only a few include enough women or analyze how the devices work specifically in women, according to research reported in Circulation: Cardiovascular Quality and Outcomes.
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For individuals of white European descent, certain variations of the gene HMGA1 are associated with type 2 diabetes mellitus, according to a study in the March 2 issue of JAMA.
Among patients with sickle cell disease, treatment of a vaso-occlusive crisis (characterized by episodes of severe pain) in the hospital with inhalation of nitric oxide gas for up to 3 days did not result in a shorter time to resolution of the pain, compared to patients who received placebo, according to a study in the March 2 issue of JAMA.
Inhaling nitric oxide gas does not reduce pain crises or shorten hospital stays in people living with sickle cell disease, according to the results of a new study sponsored by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health.
"Nitric Oxide for Inhalation in the Acute Treatment of Sickle Cell Pain Crisis," will be published in the March 2 issue of the Journal of the American Medical Association.
Indiana University scientists have solved a perplexing mystery regarding one of the body's main energy storage molecules, in the process shedding light on a possible route to treatment of a rare but deadly disease in teenagers.
An AIDS vaccine tested in people, but found to be ineffective, influenced the genetic makeup of the virus that slipped past. The findings suggest new ideas for developing HIV vaccines.
The results were published Feb. 27 in Nature Medicine.
This is the first evidence that vaccine-induced cellular immune responses against HIV-1 infection exert selective pressure on the virus. "Selective pressure" refers to environmental demands that favor certain genetic traits over others.
INDIANAPOLIS – Tanning bed exposure can produce more than some tanners may bargain for, especially when they self-diagnose and use the radiation to treat skin eruptions, according to research conducted by the Indiana University School of Medicine Department of Dermatology.
New findings published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research, confirm the risk of breast cancer among women who are obese and not physically active, and suggests additional mechanisms beyond estrogen.
Mild heart failure patients with a particular condition that results in disorganized electrical activity throughout the heart benefit substantially from cardiac resynchronization therapy with defibrillator (CRT–D), according to a study published in the American Heart Association journal Circulation.
Many people suffer from a devastating condition known as critical limb ischemia (CLI) that can lead to muscle wasting and even amputation. The disease is linked to the blockage of blood flow to the skeletal muscle and current treatment options include rehabilitative exercise and surgical bypass of blood vessels. New preclinical research suggests there may be a way to restore blood supply in skeletal muscle without traditional intervention.
In the face of the growing obesity epidemic, much research has focused on the neuronal control of feeding behavior. Agouti-related protein (AgRP) neurons express three proteins that have been implicated in changes in energy balance, but the studies linking AgRP neurons to feeding behavior have produced mixed results.
COLUMBUS, Ohio – New research has identified a small subset of normal white blood cells in the body that gives rise to a rare incurable form of leukemia.
The study, led by investigators at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James), shows that large granular lymphocyte leukemia can occur in a small subset of white blood cells called NKT cells. NKT cells share features of immune cells called T lymphocytes and features of immune cells called natural killer (NK) cells.
Scientists at the UCSF Cardiovascular Research Institute have discovered how a change in growth hormone activity in mice leads to fatty liver disease, a condition whose human counterpart is of rising concern worldwide.
Disruption of a key protein in the pathway that responds to growth hormone could explain how fatty liver disease develops, the researchers said, but may also offer insights into how our bodies regulate fat in general.
MADISON, WI, MARCH 1, 2011 – Methane is an extremely potent greenhouse gas. Wetlands, gas hydrates, permafrost, termites, oceans, freshwater bodies, non-wetland soils, are all natural sources of atmospheric methane; however, the majority of methane presence ca n be accredited to human-related activities. These activities include: such as fossil fuel production, biomass burning, waste management and animal husbandry. The release of methane into the atmosphere by cattle and other large grazing mammals is estimated to account for 12 to 17% of the total global methane release.
Alcoholism is a tough addiction to kick. Eventually, most people return to drinking. But some Dutch and German psychological scientists have tested a short-term regime that promises to help alcoholics stay sober. Their study is published in Psychological Science, a journal of the Association of Psychological Science.