Turmeric, a bright yellow spice from south Asia belonging to the ginger family, is the main ingredient in curries — and ancient wisdom suggests that it's also good for your health. Taking this wisdom to the laboratory, Tel Aviv University researchers have discovered that turmeric's active ingredient called curcumin amplifies the therapeutic activity of highly toxic anti-inflammatory drugs used to fight colon cancer when used at high doses.
Body
Jerusalem, March 1, 2011 – A pathway whereby bacteria communicate with each other has been discovered by researchers at the Hebrew University of Jerusalem. The discovery has important implications for efforts to cope with the spread of harmful bacteria in the body.
Immunological research at the University of Haifa, Israel, has made a new breakthrough, revealing a critical component in the "decision-making" process of white blood cells that play a role in the healing process from bacterial inflammation. "The process that we have discovered can assist in the development of drugs that are based on the natural processes that take place in the human body, unlike most of the existing drugs that attempt to curb inflammation by artificial means," explains Dr. Amiram Ariel of the Department of Biology at the University of Haifa, who headed the study.
Manipulation of cells by a new microfluidic device may help clinicians improve a promising cancer therapy that harnesses the body's own immune cells to fight such diseases as metastatic melanoma, non-Hodgkin's lymphoma, chronic lymphocytic leukemia and neuroblastoma.
Boston, MA - Melatonin is known to have cancer-protective properties, and shift work can induce desynchrony of the circadian system, reducing melatonin production. Shift work has been thought to have important health impacts, with evidence linking shift work to an increased risk of several cancers including breast, endometrial, prostate, and colorectal, and non-Hodgkin lymphoma. In a recent study, researchers at Brigham and Women's Hospital (BWH) found that shift work may be associated with a reduced risk of skin cancer in women.
German researchers have found a significant association of IL28B genotypes to interferon-based antiviral treatment outcome, and to graft inflammation caused by hepatitis C virus (HCV). The study determined that the presence of G-allele serves as a marker for severe HCV-induced graft inflammation, as well as a predictor for unsuccessful treatment. Study findings—the largest to report on the role IL28B variants in a transplant cohort with recurrent HCV—are published in the March issue of Liver Transplantation, a journal of the American Association for the Study of Liver Diseases.
A promising new way to inhibit cholesterol production in the body has been discovered, one that may yield treatments as effective as existing medications but with fewer side-effects.
A multinational study has identified a key gene mutation responsible for type 2 diabetes in nearly 10 percent of patients of white European ancestry.
The study, which originated in Italy and was validated at UCSF, found that defects in the HMGA1 gene led to a major drop in the body's ability to make insulin receptors – the cell's sensor through which insulin tells the cell to absorb sugar. This drop in insulin receptors leads to insulin resistance and type 2 diabetes, according to the paper.
In times of uncertainty employers should engage more openly with their staff and drop the jargon to improve communication and allow feedback, according to a paper in this month's International Journal of Productivity and Quality Management.
(Mar. 2, 2011) – HOBOKEN, NJ – The American Heart Association estimates 35 percent of adults in the U.S. suffer from metabolic syndrome, a group of risk factors characterized by obesity and the simultaneous presence of heart disease risk factors with high blood pressure, blood sugar and lipids. In patients with metabolic syndrome, high blood pressure and blood glucose gradually impair kidney function, which in turn affects the organ's ability to filter waste from the body.
The 18th Conference on Retroviruses and Opportunistic Infections is being held at the Hynes Convention Center in Boston from February 27 through March 2. Day three of this major HIV/AIDS research conference included the following selected presentations from scientists supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
iPrEx Update
MADISON — Animals' capacity to adapt is a factor in how they are likely to respond to changing climate conditions.
This conclusion of a new study published March 2 in the Proceedings of the Royal Society B is not especially surprising, says author Brandon Barton, but confirms the importance of accounting for local adaptation when determining the likely ecological effects of climate change.
Some shark species are able to navigate to specific locations up to 50km away, a new study published in the British Ecological Society's Journal of Animal Ecology has found. Re-analysing tracking data from tagged sharks, ecologists found that while some species such as blacktip reef sharks swim in a pattern known as a "random walk", others such as tiger sharks can at times hunt for prey or mates by using "directed walks", accurately navigating long distances across open ocean, often at night.
Have the suspension of central performance management of the 18 week referral to treatment target, and a relaxation of the four hour Accident and Emergency target, changed waiting times asks John Appleby, Chief Economist at the King's Fund in this week's BMJ?
The English National Health Service was once notorious for its excessive waiting times. In December 1999, nearly 160,000 patients were still waiting over six months for their first outpatient appointment and over 50,000 were still waiting over a year for a bed in hospital.
Intensive adherence counseling around the time of HIV treatment initiation significantly reduces poor adherence and virologic treatment failure in sub-Saharan Africa whereas using an alarm device has no effect, according to a study in this week's PLoS Medicine by Michael Chung from the University of Washington, Seattle, USA, and colleagues.
The findings of this study define an adherence counseling protocol that is effective; these findings are relevant to other HIV clinics caring for large numbers of patients in sub-Saharan Africa.