Scientists at the European Molecular Biology Laboratory (EMBL) and the German Cancer Research Centre (DKFZ), both in Heidelberg, Germany, have developed a new method that uncovers the combined effects of genes. Published online today in Nature Methods, it helps understand how different genes can amplify, cancel out or mask each others' effects, and enables scientists to suggest genes that interfere with each other in much the same manner that facebook suggests friends.
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A tropical frog – the only one of its kind in the world – is providing conservationists with exclusive insights into the genetic make-up of its closest endangered relatives.
University of Manchester scientists have allowed two critically endangered species of Central American Leaf frogs to interbreed, producing the unique frog – a hybrid of the two species. DNA tests using a harmless mouth swab showed that the two parent frogs were actually very closely related despite being different species.
Scientists on the Norwich Research Park have sequenced the genome of a novel strain of Clostridium botulinum, one of the most dangerous pathogens known to man. The strain produces an unusual botulinum neurotoxin, known as type A5 neurotoxin, which was isolated by the Health Protection Agency (HPA), following a case of wound botulism.
"Many people are now saying: 'Is it really that easy? Then why didn't anyone think of it a long time ago?' But you have to have the right idea at the right time," says Annette Röttger, physicist at the Physikalisch-Technische Bundesanstalt (PTB), in a pleased way. Annette Röttger and her scientific team managed to do something that was previously thought to be impossible: they developed a primary standard for the measurement of short-lived radioactive thoron.
HOUSTON, March 7, 2011 – Cleaning up pollution, protecting soil from erosion and maintaining species-rich ecosystems are some of the goals of a computational ecology project by a University of Houston (UH) scientist and his team. Published recently in a top journal, the work sheds light on a new method to speed up research in the ecology of plants.
Burkitt's lymphoma is one of the most aggressive tumors affecting humans. Multiple alterations in genes that regulate cell proliferation rate explain its aggressive behavior.
WASHINGTON, D.C. (March 7, 2011) -- All our daily activities, from driving to work to solving a crossword puzzle, depend on signals carried along the body's vast network of neurons. Propagation of these signals is, in turn, dependent on myriad small molecules within nerve cells -- receptors, ion channels, and transmitters -- turning on and off in complex cascades.
Microbicides can be used to protect against HIV, and other sexually transmitted diseases, either on their own or with the added protection of a condom. New research published by BioMed Central's open access journal AIDS Research and Therapy has investigated the use of lubricants, originally designed for vaginal application, and has developed and tested new, rectal specific, formulations.
WASHINGTON, D.C. (March 6, 2011) -- From grinding heavy metal to soothing ocean waves, the sounds we hear are all perceptible thanks to the vibrations felt by tiny molecular motors in the hair cells of the inner ear. Researchers at the University of Pennsylvania School of Medicine have now identified the mechanism by which a single amino acid change can disrupt the normal functioning of one of the critical components of that physiology -- a molecular motor protein called myo1c, which resides in the cochlea of the inner ear.
The largest-ever study of its type into coronary heart disease, involving scientists from the University of Leicester, has uncovered 13 new genes that increase risk of heart attacks.
STANFORD, Calif. — Thirteen new gene regions have been convincingly linked to coronary atherosclerosis in a massive, new, international genetics study involving investigators from the Stanford University School of Medicine.
Scientists have identified a single mutated gene that causes Hajdu-Cheney syndrome, a disorder of the bones causing progressive bone loss and osteoporosis (fragile bones). The study, published in Nature Genetics today, gives vital insight into possible causes of osteoporosis and highlights the gene as a potential target for treating the condition.
An international research collaboration has identified 13 new gene sites associated with the risk of coronary artery disease and validated 10 sites found in previous studies. Several of the novel sites discovered in the study, which is being published online in Nature Genetics, do not appear to relate to known risk factors, suggesting previously unsuspected mechanisms for cardiovascular disease.
In an improvement over open-heart surgery, cardiologists now use catheters to eliminate damaged heart tissue in certain patients, such as those with arrhythmias. But this, too, can be a long and painful procedure as many catheters, with different functions, need to be inserted sequentially.