PORTLAND, Ore. — Researchers at Oregon Health & Science University Doernbecher Children's Hospital have identified a promising new approach to overcoming drug resistance in children with an extremely aggressive childhood muscle cancer known as alveolar rhabdomyosarcoma. Their findings are published online this week in the journal Molecular Cancer Therapeutics and will be featured on the cover of the journal's print edition next month.
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The first global consensus report on meibomian gland dysfunction — a major cause of lid disease and evaporative dry eye — has been published in a special issue of the Investigative Ophthalmology & Visual Science (IOVS) journal. The report is the result of findings from a two-year-long workshop composed of more than 50 leading clinical and basic research experts from around the world.
An international study headed by a UC Davis scientist describes how a component of a potential HIV vaccine opens like a flower, undergoing one of the most dramatic protein rearrangements yet observed in nature. The finding could reveal new targets for vaccines to prevent HIV infection and AIDS. A paper describing the work was published online this week in the journal Proceedings of the National Academy of Sciences.
The first clinical study investigating the use of the AKIN criteria (Acute Kidney Injury Network) in cirrhosis has shown significant benefits that have the potential to change future diagnosis, according to results from a Spanish study presented today at the International Liver Congress.
Berlin, Germany, Thursday 31 March 2011- New data presented at the International Liver CongressTM today show the existence of novel interactions between T cells and hepatocytes that are regulated by HCV infection, providing a novel understanding of how HCV persists in the liver.
The nature of the T cell-hepatocyte interactions alter CD4+ T-cell trafficking and cytokine expression, and may have an impact on T-cell effector function and the outcome of anti-viral immune responses.
Across the globe, adolescence and early adulthood are considered important periods for the development of civic involvement. Civic involvement, in turn, has been shown to promote adolescents' development of initiative, empathy, social relations and skills, and personal growth.
Civic involvement by teens is considered important, and efforts to promote it are widespread. In this context, it's important to gain more insight into this type of involvement to inform efforts to boost youths' participation.
Food security is defined by access to sufficient, safe, and nutritious food to maintain a healthy and active life, according to the World Health Organization. In the United States and Canada, the number of households considered food insecure has increased more than 50 percent over the past four years, with one in three households in the United States experiencing very low food security. Young children and households headed by women are disproportionately affected.
Although adolescents need just as much sleep as younger children, sleep times decrease over the course of development, leaving many teens chronically sleep-deprived. Studies have consistently indicated that insufficient sleep can have a negative effect on many aspects of adolescents' lives, leading to mood disturbances, poorer physical health, and academic difficulties. But few studies have examined how sleep affects the ways adolescents function on a daily basis or how the effects of sleep change over time.
Cincinnati, OH, March 31, 2011 -- Roughly 15% of children suffer from migraines, and approximately one-third of these affected children have migraines with aura, a collection of symptoms that can include weakness, blind spots, and even hallucinations. Although the causes of migraines are unclear, a new study soon to be published in The Journal of Pediatrics suggests a connection between migraine headaches in children and a heart defect called patent foramen ovale, which affects 25% of people in the U.S.
ANAHEIM, March 30, 2011 — In the first report on the uptake and internal processing of triclocarban (TCC) in fish, scientists today reported strong evidence that TCC — an antibacterial ingredient in some soaps and the source of environmental health concerns because of its potential endocrine-disrupting effects — has a "strong" tendency to bioaccumulate in fish. They presented the findings here today at the 241st National Meeting & Exposition of the American Chemical Society.
ANAHEIM, March 30, 2011 — Military personnel and contractors stationed in Iraq risk not only enemy gunfire, suicide bombers, and roadside bombs, but the very air they breathe often is polluted with dust and other particles of a size and composition that could pose immediate and long-term health threats, scientists reported today at the 241st National Meeting of the American Chemical Society.
Speaking at the UK National Stem Cell Network annual science meeting later today (30 March), Professor Miguel Forte will describe research into a new cell therapy for chronic inflammatory conditions such as Crohn's disease. Patient's own blood cells are used to produce a type of cell – Type 1 T regulatory lymphocyte – that can reduce the extent of the disease.
A three-drug cocktail can eliminate the hepatitis C virus in patients far more effectively than the current two-drug regimen, according to researchers at Henry Ford Hospital.
"This study represents a remarkable advance and a potential cure for people with hepatitis C who have not responded to previous therapy," says co-author Stuart C. Gordon, M.D., section chief for the Division of Hepatology at Henry Ford Hospital.
(PHILADELPHIA) Giving girls with Turner syndrome low doses of estrogen, as well as growth hormone, years before the onset of puberty, increases their height and offers a wealth of other benefits, say a team of researchers led by Thomas Jefferson University. Their report is published in the March 31st issue of The New England Journal of Medicine (NEJM).
ST. LOUIS – The drug boceprevir helps cure hard-to-treat hepatitis C, says Saint Louis University investigator Bruce R. Bacon, M.D., author of the March 31 New England Journal of Medicine article detailing the study's findings. The results, which were first reported at the 61st annual meeting of the American Association for the Study of Liver Disease's last November, offer a brighter outlook for patients who have not responded to standard treatment.