The wolves and moose of Isle Royale have done it again. They've surprised the scientists who have spent more than half a century studying them.
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New research suggests that infection with a probiotic strain of E. coli bacteria could help treat an reduce the negative effects of another E. coli infection that may be associated with Crohn's disease. Researchrs from the University of Auckland, New Zealand publish their results in the April 2011 issue of the journal Applied and Environmental Microbiology.
ANAHEIM, March 31, 2011 — In a scientific advance literally plucked from the waste heap, scientists today described a key step toward using the billions of pounds of waste chicken feathers produced each year to make one of the more important kinds of plastic. They described the new method at the 241st National Meeting & Exposition of the American Chemical Society, being held here this week.
Results from an international study presented today at the International Liver Congress have shown Obeticholic Acid (OCA) is a safe and effective treatment in patients suffering from Primary Biliary Cirrhosis (PBC) as demonstrated by substantial decreases in the levels of alkaline phosphatase (AP) enzyme in the blood, a key marker for PBC.
In this double blind parallel group study, 59 patients received 10 or 50mg of OCA or a placebo once a day for 12 weeks. After 12 weeks the 10mg group showed the greatest reduction in AP levels.
NEW YORK (March 31, 2011) -- Researchers at Weill Cornell Medical College have shown that it is possible to immunize mammals to control fertility. They say their technique could possibly be used on other mammals -- including humans -- because fertility hormones and their receptors are species-non-specific and are similar in both females and males. For pets, the technique could be an alternative to castration and adverse effects of hormone administration.
CLEVELAND -- Dr. Leona Cuttler, a pediatric endocrinologist and growth hormone expert from University Hospitals Rainbow Babies and Children's Hospital, is the co-author of an editorial in the New England Journal of Medicine commenting on a new study that found giving girls with Turner syndrome low doses of estrogen, as well as growth hormone, years before the onset of puberty, increases their height and offers other benefits.
A new study uncovers a previously unrecognized link between tobacco smoking and a gene known to influence the cardiovascular system, possibly identifying an early stage of smoking-associated cardiovascular pathology. The research, published by Cell Press in the April issue of The American Journal of Human Genetics, may serve to guide future research strategies aimed at identifying and counteracting mechanisms of smoking-induced pathology.
Myotonic dystrophy type 1 (DM1) is the most common inherited muscular dystrophy in adults. New research published by Cell Press online on March 31st in the journal Cell Stem Cell, uses human embryonic stem cells to make a clinically-important contribution to the understanding of this disease, and highlights the incredible potential that embryonic stem cells hold for unraveling the complex molecular mechanisms involved in a variety of human conditions.
DURHAM, N.C. – New genomic analyses suggest that the most common genetic variants in the human genome aren't the ones most likely causing disease. Rare genetic variants, the type found most often in functional areas of human DNA, are more often linked to disease, genetic experts at Duke University Medical Center report.
The study was published in the American Journal of Human Genetics on March 31.
Biologists at UC San Diego have identified the molecular mechanisms triggered by starvation in fruit flies that enhance the nervous system's response to smell, allowing these insects and presumably vertebrates—including humans—to become more efficient and voracious foragers when hungry.
Their discovery of the neural changes that control odor-driven food searches in flies, which they detail in a paper in the April 1 issue of the journal Cell, could provide a new way to potentially regulate human appetite.
Hospitals can reduce the risk of life-threatening bloodstream infections in children with peripherally inserted central venous catheters by assessing daily the patient's progress and removing the device as early as possible, according to a new Johns Hopkins Children's Center study published online March 31 in the journal Clinical Infectious Diseases.
The findings will be presented on Saturday, April 2, at the annual meeting of the Society for Healthcare Epidemiology of America.
Berlin, Germany, Thursday 31 March 2011- New data presented at the International Liver CongressTM today show the existence of novel interactions between T cells and hepatocytes that are regulated by HCV infection, providing a novel understanding of how HCV persists in the liver.
The nature of the T cell-hepatocyte interactions alter CD4+ T-cell trafficking and cytokine expression, and may have an impact on T-cell effector function and the outcome of anti-viral immune responses.
A new discovery published in the April 2001 issue of Journal of Leukocyte Biology (http://www.jleukbio.org) raises hope that new treatments for illnesses like Crohn's disease and ulcerative colitis are on the horizon. That's because they've identified IL-23, a cytokine used by the immune system to ward off disease, as a major contributor to the inflammation that is the hallmark of these illnesses.
A two-year trial of entecavir followed by lamivudine (LAM) in patients with chronic hepatitis B virus (HBV) infection resulted in a virologic rebound rate of 24% and 12% drug-resistance rate. Patients who continued on entecavir therapy throughout the study period had undetectable HBV DNA at the two-year endpoint. Details of this trial are published in the April issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases.
In what could be a potential breakthrough in the battle against AIDS and a major development in the rational design of new drugs, scientists have engineered a new protein that prevents the virus from entering cells. This protein is based on a naturally occurring protein in the body that protects cells from viruses, except the man-made version does not cause inflammation and other side effects at the dosages needed to inhibit AIDS. This discovery was published in the April 2011 issue of The FASEB Journal (http://www.fasebj.org).