Some 2.6 million third trimester stillbirths worldwide occur every year, according to the first comprehensive set of stillbirth estimates, published today within a special series in the medical journal The Lancet.
Every day more than 7,300 babies are stillborn. A death occurs just when parents expect to welcome a new life.
Infectious disease is a huge cause of death globally, and is a particular threat to newborns whose immune systems respond poorly to most vaccines. A new approach developed at Children's Hospital Boston, using an adjuvant (an agent to stimulate the immune system) along with the vaccine, shows promise in a study of blood from Gambian infants. Results will appear in the open-access journal PLoS ONE on April 13.
Animal cell membranes are a bilayer of phospholipids (charged fat molecules) made up to various degrees of fatty acids that must be acquired from the diet. The essential polyunsaturated fatty acids have been shown to be important in resistance to a variety of diseases and in coping with changes in body temperature. It is generally believed that mammals are unable to alter the proportions of essential fatty acids in their cell membranes except by changing their diets.
For the first time, scientists at Toronto General Hospital, University Health Network have shown in a clinical trial that the Toronto XVIVO System can safely and effectively treat, re-assess and improve the function of high-risk donor lungs so that they can be successfully transplanted into patients. The use of this technique could significantly expand the donor organ pool and improve outcomes after transplantation.
ANN ARBOR, Mich.---The ongoing spread of non-native mussels in the Great Lakes has caused "massive, ecosystem-wide changes" throughout lakes Michigan and Huron, two of the planet's largest freshwater lakes, according to a new University of Michigan-led study.
The blitzkrieg advance of two closely related species of mussels---the zebra and quagga---is stripping the lakes of their life-supporting algae, resulting in a remarkable ecological transformation and threatening the multibillion-dollar U.S. commercial and recreational Great Lakes fisheries.
DALLAS – April 14, 2011 – A natural hormone known to inhibit aging can also protect kidneys against renal fibrosis, UT Southwestern Medical Center researchers have demonstrated.
Scientists led by Dr. Makoto Kuro-o, associate professor of pathology, showed in mice that the anti-aging hormone Klotho suppressed both renal fibrosis – a common complication of chronic kidney disease – and the spread of cancer. The findings are available online in the Journal of Biological Chemistry.
It is well known that the human body has a highly developed immune system to detect and destroy invading pathogens and tumor cells. Now, researchers at the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have shown that the body has a second line of defense against cancer – healthy cells. A new study shows that normal mammary epithelial cells, as they are developing, secrete interleukin 25, a protein known for its role in the immune system's response to inflammation, for the express purpose of killing nearby breast cancer cells.
To ensure normal fetal development and prevent disease, it is crucial that certain genes are on or off in the right time intervals. Researchers in Professor Kristian Helin's group at BRIC, University of Copenhagen, have now shown how the TET1 enzyme controls the activity of our genes. The results are just published in the journal Nature.
Control of our genes
MANHATTAN, Kan. -- A new biophysical and biochemical study may lead to better understanding of how structural flexibility controls the interaction of a protein that is closely involved with cancer, aging and other chronic diseases -- thereby facilitating future development of better therapeutic strategies, according to a Kansas State University biochemist.
Researchers at the Johns Hopkins Bloomberg School of Public Health have developed a non-steroid based strategy for improving the lung's innate immune defense and decreasing inflammation that can be a problem for patients with chronic obstructive pulmonary disease (COPD). In a study published in the April 13 edition of the journal Science Translational Medicine, the Johns Hopkins researchers targeted the Nrf2 pathway using sulforaphane, an ingredient that is present in broccoli in a precursor form, to enhance the Nrf2 pathway in the lung that mediates the uptake of bacteria.
With the collapse of the Soviet Union, Russians were faced with more than the demise of a political system. Working-age men began dying in droves, and the country saw a 40 percent surge in deaths between 1990 and 1994.
The killer was often alcohol – that much was clear. And for years, many economists and political scientists have blamed Russia's lurch toward democracy and capitalism for driving those men to drink. They reasoned that privatization left many people unskilled and unemployable, ushering in a sense of listlessness and depression that mixed too easily with cheap vodka.
WASHINGTON, DC – Walking on a treadmill for one hour a day may slow the progression of nonalcoholic fatty liver disease in obese people with prediabetes by jump-starting their metabolism and slowing the oxidative damage wrought by the condition, say researchers at the Cleveland Clinic. A study of 15 obese people with nonalcoholic fatty liver disease revealed that the daily walks not only increase insulin sensitivity, but improve the liver's polyunsaturated lipid index (PUI), which is thought to be a marker of liver health.
WASHINGTON – Approximately one million Americans suffer a heart attack each year of which some 400,000 attacks are fatal. A key cause of heart attacks is atherosclerosis, a process in which cholesterol builds up in the arteries and impedes the ability of the blood to flow to our most vital organ. Atherosclerosis is often associated with a high-fat diet in humans, but in a new study using an animal model researchers have found that a high-fat diet for a very short period can protect the heart from heart attacks and result in less tissue damage when heart attacks occur.
WASHINGTON – Walking on a treadmill for one hour a day may slow the progression of nonalcoholic fatty liver disease in obese people with prediabetes by jump-starting their metabolism and slowing the oxidative damage wrought by the condition, say researchers at the Cleveland Clinic. A study of 15 obese people with nonalcoholic fatty liver disease revealed that the daily walks not only increase insulin sensitivity, but improve the liver's polyunsaturated lipid index (PUI), which is thought to be a marker of liver health.
CINCINNATI—A new study from researchers at the University of Cincinnati (UC) shows that short-term, high-fat "splurges" within one's diet could elicit cardioprotective properties during a heart attack.
These findings are being presented for the first time at the 2011 Experimental Biology Meeting sponsored by the American Society for Pharmacology and Experimental Therapeutics on April 13 in Washington, D.C.