Boston, MA - Researchers at Brigham and Women's Hospital (BWH) have identified a new combination of targeted therapies that, together, may treat two aggressive tumor types that until now have not had effective treatments. These findings are published in Cancer Cell on September 13, 2011.
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LA JOLLA, CA - Oncologists have long sought a powerful "magic bullet" that can find tumors wherever they hide in the body so that they can be imaged and then destroyed. Until recently scientists accepted the notion that such an agent, an agonist, needed to enter and accumulate in the cancerous cells to act. An international research team has now shown in cancer patients that an investigational agent that sticks onto the surface of tumor cells without triggering internalization, an antagonist, may be safer and even more effective than agonists.
CLEMSON, S.C. — Celebrating the end to a successful peach season, Clemson University peach specialist Desmond Layne announced the naming of a new peach cultivar — CaroTiger. The fourth in the "Caro" — for South Carolina — series, this late-season peach will be available to growers in January 2013.
Researchers at Emory University School of Medicine have identified a new type of potential anticancer drug. The compound, named FOBISIN, targets 14-3-3 proteins, important for the runaway growth of cancer cells.
The researchers were using X-rays to see how FOBISIN fits into the clamp-shaped 14-3-3 protein structure. Unexpectedly, the X-rays induced the compound to be permanently bonded to the protein. The finding suggests that compounds like FOBISIN can be used in combination with radiation to trigger potent anticancer activity.
SEATTLE – A research team led by Fred Hutchinson Cancer Research Center has discovered proteins in the blood that are associated with early lung cancer development in mice and humans. The advance brings the reality of a blood test for the early detection and diagnosis of lung cancer a step closer.
The findings, by a team led by Samir Hanash, M.D., Ph.D., head of the Hutchinson Center's Molecular Diagnostics Program and member of its Public Health Sciences Division, are published online Sept. 12 ahead of the Sept. 13 print issue of Cancer Cell.
Lung cancer is one of the most common and deadly types of cancer. Mouse models of lung cancer recapitulate many features of the human disease and have provided new insight about cancer development, progression and treatment. Now, a new study published by Cell Press in the September 13th issue of the journal Cancer Cell identifies protein signatures in mouse blood samples that reflect lung cancer biology in humans.
Researchers at University Medical Center Utrecht, the Netherlands, have discovered a substance that has an adverse effect on nearly all types of chemotherapy - making cancer cells insensitive to the treatment. Chemotherapy often loses effectiveness over time. It is often unclear how or why this happens.
CINCINNATI—With the discovery of a RNA nano-scaffold that remains unusually stable in the body, researchers at the University of Cincinnati (UC) have overcome another barrier to the development of therapeutic RNA nanotechnology.
Peixuan Guo, PhD, Dane and Mary Louise Miller Endowed Chair and professor of biomedical engineering, and his colleagues in UC's College of Engineering and Applied Sciences report the construction of a thermodynamically stable RNA nanoparticle online in the journal Nature Nanotechnology.
HOUSTON -- Gene therapy delivered directly to a particularly stubborn type of breast cancer cell causes the cells to self-destruct, lowers chance of recurrence and helps increase the effectiveness of some types of chemotherapy, researchers at The University of Texas MD Anderson Cancer Center reported in the Sept. 13 edition of Cancer Cell.
PHILADELPHIA - It's no secret that a high-fat diet isn't healthy. Now researchers have discovered a molecular clue as to precisely why that is.
EAST LANSING, Mich. — There are many old wives' tales about what determines a baby's sex, yet it is the tight controls at the gene level that determine an organism's sex in most species. Researchers at Michigan State University have found that even when genetic and genomic mechanisms are disrupted, organisms quickly evolve ways to compensate.
A study published in the October issue of Infection Control and Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of America, uses a famous case of international intrigue and murder to shed new light on the risks health care workers face while treating patients with radiation poisoning.
Flitting among the cool slopes of the Appalachian Mountains is a tiger swallowtail butterfly that evolved when two other species of swallowtails hybridized long ago.
It's a rarity in the animal world, biologists have found.
They discovered that the Appalachian tiger swallowtail, Papilio appalachiensis, evolved from mixing between the Eastern tiger swallowtail, P. glaucus, and the Canadian tiger swallowtail, P. canadensis.