Using a mouse model of rheumatoid arthritis, scientists have discovered that a form of cellular immunotherapy by intravenous administration of monocytic myeloid-derived suppressor cells, or M-MDSCs, might be an effective treatment for the disease in humans. In a report published in the March 2015 issue of the Journal of Leukocyte Biology, researchers show that M-MDSCs are capable of inhibiting T cell proliferation, as well as B cell proliferation and antibody production. As a result, the arthritic mice experienced improvements in their symptoms.
Body
New research with mice undercuts widely held belief that ubiquinone protects cells against damage from free radicals.
The popular dietary supplement ubiquinone, also known as Coenzyme Q10, is widely believed to function as an antioxidant, protecting cells against damage from free radicals. But a new study by scientists at McGill University finds that ubiquinone is not a crucial antioxidant -- and that consuming it is unlikely to provide any benefit.
A new study scheduled for presentation at a meeting of the American College of Cardiology found that screening for and treating depression could help to reduce the risk of heart disease in patients with moderate to severe depression.
Sitting for many hours per day is associated with increased coronary artery calcification, a marker of subclinical heart disease that can increase the risk of a heart attack, according to research scheduled for presentation at the American College of Cardiology's 64th Annual Scientific Session in San Diego. Coronary artery disease is the most common type of heart disease and the leading cause of death in the United States.
A new study by researchers at the Intermountain Medical Center Heart Institute has found that screening for and treating depression could help to reduce the risk of heart disease in patients with moderate to severe depression.
The molecular complex that guides an important class of proteins to correct locations in cell membranes does so by forming a dimeric structure with a protective pocket, according to a new report. This structure shields tail-anchored membrane proteins - which have roles in a wide variety of cellular functions from neurotransmitter release to insulin production - from harmful aggregation or misfolding as they move through the inner environment of a cell. The findings clarify the mechanism behind a fundamental biological process.
Male partners of infertile obese females may increase the odds of conceiving a child by improving their own weight and dietary habits, preliminary results from a pilot study from Canada suggest. The results will be presented Thursday, March 5, at ENDO 2015, the annual meeting of the Endocrine Society in San Diego.
The composition of intestinal bacteria and other micro-organisms--called the gut microbiota--changes over time in unhealthy ways in black men who are prediabetic, a new study finds. The results will be presented Friday at the Endocrine Society's 97th annual meeting in San Diego.
Exposure to hormone-altering chemicals called phthalates - which are found in many plastics, foods and personal care products - early in pregnancy is associated with a disruption in an essential pregnancy hormone and adversely affects the masculinization of male genitals in the baby, according to research led by the University of Pittsburgh Graduate School of Public Health.
Injecting botulinum toxin A (known commercially as Botox) appears to be a safe procedure to improve smiles by restoring lip symmetry in children with facial paralysis, a condition they can be born with or acquire because of trauma or tumor, according to a report in JAMA Facial Plastic Surgery.
A new study has found women who smoke when pregnant are putting their daughters at a greater risk of developing ovarian and breast cancer later in life.
The Australian National University (ANU) study, published in Human Reproduction, found mothers who reported smoking most days while pregnant had daughters who had an earlier age of first menstruation, or menarche.
New research published in Diabetologia shows that use of statins is associated with a 46% increase in the risk of developing diabetes, even after adjustment for confounding factors. The study is by Professor Markku Laakso, Institute of Clinical Medicine, University of Eastern Finland and Kuopio University Hospital, Finland, and colleagues.
Obesity, hypertension and diabetes are known risk factors for heart failure, a chronic condition in which the heart cannot pump enough blood to meet the body's needs. For the first time, scientists have quantified the average number of heart failure-free years a person gains by not developing those risk factors by age 45, according to a study scheduled for presentation at the American College of Cardiology's 64th Annual Scientific Session in San Diego.
Two studies scheduled for presentation at the American College of Cardiology's 64th Annual Scientific Session in San Diego failed to find a connection between testosterone therapy in men and heart problems, contradicting research that prompted the U.S. Food and Drug Administration to investigate its safety. The new studies include a meta-analysis of data from 29 studies involving more than 120,000 men and an observational study from a Wisconsin health system.
Taking omega-3 fatty acids appeared to lower inflammation and guard against further declines in heart function among recent heart attack survivors already receiving optimal standard care, according to results from a randomized, controlled trial to be presented at the American College of Cardiology's 64th Annual Scientific Session in San Diego.