Scientists at the University of Cambridge have successfully created 'mini-lungs' using stem cells derived from skin cells of patients with cystic fibrosis, and have shown that these can be used to test potential new drugs for this debilitating lung disease.
Body
Using melatonin could provide more and better quality sleep compared to using an eye mask and earplugs in a simulated noisy and illuminated environment, according to research published in open access journal Critical Care. This study was carried out on healthy subjects but could have future implications for intensive care unit (ICU) patients.
New research published in Diabetologia shows that in women who have developed gestational diabetes mellitus (GDM) during pregnancy, being obese before the pregnancy and putting on more weight after it massively increases the risk of later developing type 2 diabetes (T2D).
In diseases such as asthma and chronic obstructive pulmonary disease (COPD), the body produces too much mucus, making breathing difficult. New research from Washington University School of Medicine in St. Louis provides clues to potentially counteract inappropriate mucus production.
Researchers at the San Diego Supercomputer Center (SDSC) and the Moores Cancer Center at the University of California, San Diego, have described for the first time the molecular mechanism of cancer development caused by well-known "resistance" mutations in the gene called epidermal growth factor receptor (EGFR). While these mutations were known for quite a long time, the question as to why they cause cancer or make some drugs ineffective was still not answered.
Most animals have a dorso-ventral (back-to-belly) body axis, which determines for instance the localized position of the central nervous system, dorsal in humans, ventral in insects. Surprisingly, despite enormous morphological differences, the same signaling molecules of Bone morphogenetic protein (BMP) molecules establishes the dorso-ventral axis including the central nervous system in both insects and vertebrates, which led to the conclusion that this molecular mechanism was already present in the common ancestor.
Among approximately 19,000 individuals, the use of aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs) was associated with an overall lower risk of colorectal cancer, although this association differed according to certain genetic variations, according to a study in the March 17 issue of JAMA.
A comprehensive study examining clinical trials of more than 95,000 patients has found that glucose or sugar-lowering medications prescribed to patients with diabetes may pose an increased risk for the development of heart failure in these patients.
Cancer cells crowded tightly together suddenly surrender their desire to spread, and this change of heart is related to a cellular pathway that controls organ size. These two stunning observations are reported today by researchers at Georgetown Lombardi Comprehensive Cancer Center in the journal Oncogene.
New research found that bat activity was generally lower in street-lit areas than in dark locations with similar habitat, which means the popular belief that street lighting is attractive to common bats is not true and they don't benefit from them when feeding on the insects that congregated around them.
In a study that included more than 20,000 adults in China with high blood pressure but without a history of stroke or heart attack, the combined use of the hypertension medication enalapril and folic acid, compared with enalapril alone, significantly reduced the risk of first stroke, according to a study appearing in JAMA. The study is being released to coincide with its presentation at the American College of Cardiology Annual Scientific Session.
Hair and teeth are ectodermal appendages that share common developmental mechanisms. However, the major structural components making up hair and teeth are very distinct. The hair shaft is essentially made of keratin filaments that are highly cross-linked. Tooth enamel matrix is primarily composed of enamel proteins (amelogenin, ameloblastin) that are degraded and replaced by minerals during enamel maturation. Fully mineralized enamel contains a small fraction of cross-linked organic material that has not been fully characterized.
Researchers in the UK have, for the first time, shown how exhaust pollution from diesel engines is able to affect nerves within the lung. Air pollution is a significant threat to health, they say, and identifying potential mechanisms linking exposure to diesel exhaust and the exacerbation of respiratory diseases may lead to treatments for those affected.
living beings can keep gene expression in check -- which might partly explain the uncontrolled gene expression found in many cancers.
"Using yeast as a model organism, we studied the Tup1 protein, a negative regulator of gene expression," says Biology Professor Emanuel Rosonina, adding, "This protein binds to some genes and blocks their expression, helping to ensure genes that shouldn't be turned on remain inactive."
Scientists at Benaroya Research Institute at Virginia Mason (BRI) have made an unexpected discovery that overturns a longstanding belief in the biological sciences. Research, led by Chris Amemiya, PhD, a member at BRI, and primarily conducted by Joyce Tang, was published online in today's issue of Current Biology. The research demonstrates that chitin, a molecule that was previously thought to be absent in vertebrates and that has been shown to trigger an allergy/immune reaction in mammals, is endogenously produced in fishes and amphibians.