A new study led by Vanderbilt University Medical Center investigators found new diagnoses of prostate cancer in the U.S. declined 28 percent in the year following the draft recommendation from the United States Preventive Services Task Force (USPSTF) against routine PSA screening for men. The new research, led by first author Daniel Barocas, M.D., MPH, assistant professor of urological surgery and medicine, was posted online in the June 15 issue of The Journal of Urology in advance of publication.
Body
Inside the cell, DNA is tightly coiled and packed with several proteins into a structure called "chromatin", which allows DNA to fit in the cell while also preventing genes from being expressed at the wrong time. Guided by a chemical "barcode", specialized effector proteins can bind chromatin and either unwind it or compact further to activate or silence genes. This system has enormous implications for biology and medicine, e.g. cancer research. However, the efficiency of effector-chromatin interactions have been elusive, especially given the weak binding between the two.
The recent craze for human breast milk amongst certain fitness communities, fetishists and chronic disease sufferers is ill advised say the authors of an editorial published today by the Journal of the Royal Society of Medicine. There is a lucrative online market for adult buyers of human breast milk, with websites and forums describing it as a 'clean' super food that can lead to gains in the gym, and even help with erectile dysfunction and cancer. There are claims that it is more digestible and contains positive immune building properties.
Melanoma patients with high levels of a protein that controls the expression of pro-growth genes are less likely to survive, according to a study led by researchers at Icahn School of Medicine at Mount Sinai and published online in the journal Molecular Cell.
A new study led from Karolinska Institutet in Sweden links male infertility to autoimmune prostatic inflammation. The findings are published in the journal Science Translational Medicine.
Involuntary childlessness is common, and in half of all cases attributable to infertility in the man. Although male infertility has many possible causes, it often remains unexplained.
'Walk through any supermarket and take a look at the labels on food products, and you'll see that many of them contain fructose, often in the form of sucrose (table sugar)' -- that's how Wilhelm Krek, professor for cell biology at ETH Zurich's Institute for Molecular Health Sciences, summarizes the problem with today's nutrition.
Prognosis for breast cancer is relatively good when detected in its early stages, metastatic disease is the cause of 90 percent of all cancer-related deaths. Therefore, learning more about the metastatic process and finding new cures to inhibit disease spread is at the center of clinical attention.
Often referred to as the "body clock", circadian rhythm controls what time of day people are most alert, hungry, tired or physically primed due to a complex biological process that is not unique to humans. Circadian rhythms, which oscillate over a roughly 24-hour cycle in adaptation to the Earth's rotation, have been observed in most of the planet's plants, animals, fungi and cyanobacteria, and are responsible for regulating many aspects of organisms' physiological, behavioral and metabolic functions.
New human heart muscle cells can be formed, but this mainly happens during the first ten years of life, according to a new study from Karolinska Institutet in Sweden. Other cell types, however, are replaced more quickly. The study, which is published in the journal Cell, demonstrates that the heart muscle is regenerated throughout a person's life, supporting the idea that it is possible to stimulate the rebuilding of lost heart tissue.
We've all been there: We eat an entire sleeve of fat-free, low-calorie cookies and we're stuffing ourselves with more food 15 minutes later.
One theory to explain this phenomenon is that artificial sweeteners don't contain the calories or energy that evolution has trained the brain to expect from sweet-tasting foods, so they don't fool the brain into satisfying hunger. However, until now, nobody understood how organisms distinguish between real sugar and artificial sweetener.
Adults who are following the DASH-style eating pattern to lower their blood pressure can expand their protein options to include lean, unprocessed pork, according to research from Purdue University.
'This study supports that the DASH diet can include lean, unprocessed red meats in the appropriate serving sizes,' said Wayne Campbell, a professor of nutrition science.
New recommendations by EULAR for women's health and pregnancy in patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS) were presented today at the European League Against Rheumatism Annual Congress (EULAR 2015). Developed by expert consensus, these evidence-based recommendations provide crucial guidance to support family planning, assisted reproduction, pregnancy and the menopause in these patients.
Housing improvements could reduce malaria cases by half in some settings, according to research published in the open access Malaria Journal.
As mosquitoes become resistant to insecticides and malaria parasites become resistant to drugs, researchers looked at how making changes to houses might contribute to tackling the deadly disease.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found that a drug candidate with anticancer potential can be activated by one of the body's natural responses to cellular stress. Once activated, the agent can kill prostate cancer cells.
"There is no proven drug right now with these activities," said Ben Shen, vice chair of TSRI's Department of Chemistry and senior author of the new study, "so this points the way toward a new therapeutic opportunity."
A Canadian study published in the June issue of the journal CHEST found weight loss reduced asthma severity as measured by airway hyperresponsiveness (AHR) in obese adults. The incidence of asthma is 1.47 times higher in obese people than non-obese people, and a three-unit increase in body mass index is associated with a 35% increase in the risk of asthma.