Researchers at Beth Israel Deaconess Medical Center (BIDMC) have identified a new vitamin B3 pathway that regulates liver metabolism. The discovery provides an opportunity to pursue the development of novel drug therapies to address obesity, type 2 diabetes and related metabolic diseases.
Published in the August 2015 issue of Nature Medicine, the new findings show that a small molecule called N1-methylnicotinamide prevents metabolic complications caused by a high-fat diet.
Patients with low testosterone levels who have then gone on to have testosterone replacement therapy (TRT) could be at lower risk of cardiovascular events such as heart attack or stroke, according to research published today (Thursday) in the European Heart Journal.
Researchers have identified a protein produced by white blood cells that puts the brakes on muscle repair after injury.
By removing the protein CD163 from mice, scientists at Emory University School of Medicine could boost muscle repair and recovery of blood flow after ischemic injury (damage caused by restriction of blood flow).
Researchers from the University of Surrey and Lund University (Sweden) investigated how frequent, long-distance travel is represented in mass and social media. They found that the images portrayed do not take into account the damaging side effects of frequent travel such as jet-lag, deep vein thrombosis, radiation exposure, stress, loneliness and distance from community and family networks.
Cancer cells in neuroblastoma contain a molecule that breaks down a key energy source for the body's immune cells, leaving them too physically drained to fight the disease, according to new research published in the journal Cancer Research today (Saturday).
Cancer Research UK-funded scientists have discovered that the cells in neuroblastoma - a rare type of childhood cancer that affects nerve cells - produce a molecule that breaks down arginine, one of the building blocks of proteins and an essential energy source for immune cells.
New research by scientists at the University of York has given tea and coffee drinkers new information about why their favourite drinks taste as they do.
The study led by Dr Seishi Shimizu, of the York Structural Biology Laboratory in the University's Department of Chemistry, shows that sugar has an important effect in reducing the bitterness of tea and coffee, not just by masking it but by influencing the fundamental chemistry.
A metabolic imbalance caused by radiation from your wireless devices could be the link to a number of health risks, such as various neurodegenerative diseases and cancer, a recent study suggests.
“Oxidative Mechanisms of Biological Activity of Low-intensity Radiofrequency Radiation,” a review article published in Electromagnetic Biology & Medicine, explores experimental data on the metabolic effects of low-intensity radiofrequency radiation in living cells.
More time spent standing rather than sitting could improve your blood sugar, fats in the blood and cholesterol levels, according to a new study published today (Friday) in the European Heart Journal. The study also shows that replacing time spent sitting with time walking could have additional benefits for your waistline and body mass index (BMI).
In patients with chronic kidney disease (CKD), atherosclerosis is exceedingly common and contributes to the development of heart disease, which is the leading cause of death in this group. New research suggests that an organic byproduct generated by intestinal bacteria may be responsible for the formation of cholesterol plaques in the arteries of individuals with decreased kidney function.
Follicular helper Tcells (TFH cells), a rare type of immune cell that is essential for inducing a strong and lasting antibody response to viruses and other microbes, have garnered intense interest in recent years but the molecular signals that drive their differentiation had remained unclear. Now, a team of researchers at the La Jolla Institute for Allergy and Immunology has identified a pair of master regulators that control the fate of TFH cells.
Cancer Research UK scientists have for the first time identified that there are five distinct types of prostate cancer and found a way to distinguish between them, according to a study in EBioMedicine.
The findings could have important implications for how doctors treat prostate cancer in the future, by identifying tumours that are more likely to grow and spread aggressively through the body.
The researchers, from the Cancer Research UK Cambridge Institute and Addenbrooke's Hospital, studied samples of healthy and cancerous prostate tissue from more than 250 men.
Cancer can be caused solely by protein imbalances within cells, a study of ovarian cancer has found.
The discovery is a major breakthrough because, until now, genetic aberrations have been seen as the main cause of almost all cancer.
The research, published today in the journal Oncogene, demonstrates that protein imbalance is a powerful prognostic tool, indicating whether or not patients are likely to respond to chemotherapy and whether a tumour is likely to spread to other sites.
A metabolic imbalance caused by radiation from your wireless devices could be the link to a number of health risks, such as various neurodegenerative diseases and cancer, according to a recent review which claims experimental data links metabolic effects of low-intensity radiofrequency radiation and living cells.
Looking at measurements of the vertebrae - the series of small bones that make up the spinal column - in newborn children, investigators at Children's Hospital Los Angeles found that differences between the sexes are present at birth. Results of the study, now online in advance of publication in the August issue of the Journal of Pediatrics, suggest that this difference is evolutionary, allowing the female spine to adapt to the fetal load during pregnancy.
Washington State University scientists have found that glyphosate, the main ingredient in the herbicide Roundup, does not accumulate in mother's breast milk.
Michelle McGuire, an associate professor in the WSU School of Biological Sciences, is the lead researcher of the study, the first to have its results independently verified by an accredited, outside organization.