Body

Social isolation could be associated with increased inflammation in the body new research from the University of Surrey and Brunel University London has found.

In the largest study of its kind researchers investigated the link between social isolation and loneliness with inflammation in the body. Analysing 30 previous studies in this area researchers found that social isolation could be linked to increased inflammation in the body.

Philadelphia, March 5, 2020--Researchers at Children's Hospital of Philadelphia (CHOP) have found that children with a rare food allergy known as food protein-induced enterocolitis syndrome, or FPIES, have a significantly higher chance of being diagnosed with other allergic conditions, including eczema, traditional food allergy and asthma. But the researchers also found that FPIES did not directly cause those other allergies.

The study was published in the March issue of The Journal of Allergy and Clinical Immunology: In Practice.

Philadelphia, March 5, 2020--Researchers at Children's Hospital of Philadelphia (CHOP) have developed a novel treatment for sepsis - one of the leading causes of hospital death - that enhances the body's bacteria-capturing neutrophil extracellular traps (NETs) so that they more effectively capture infectious bacteria, resist degradation, and improve sepsis outcomes and survival.

An international team of researchers led by scientists at Baylor College of Medicine has new insights into the function of neurofibromin, a tumor suppressor produced by the NF1 gene. It is well known that neurofibromin keeps cancer growth in check by repressing the activity of a cancer driver called Ras. The new research reveals a previously unknown function of neurofibromin -- directly repressing gene expression controlled by the estrogen receptor-α (ER).

Researchers have identified a promising new drug combination that could significantly help the immune system target cancer cells and kill them.

The study published in Cell, describes a treatment that works by combining an intravenous dosage of a well known anti-nausea drug, prochlorperazine (called Stemetil in Australia), with existing cancer treatments.

University of Queensland (UQ) scientist Associate Professor Fiona Simpson, who led the exhaustive research project, said it could lead to new treatments for some cancers.

What The Study Did: The secretion of melatonin is an important indicator of the body's circadian rhythm. An internal circadian rhythm misaligned with the outside world and a low concentration of melatonin secretion have been associated with risk for a variety of diseases. This randomized clinical trial investigated whether cataract surgery, which increases a person's perception of light, affected melatonin secretion in patients 60 and older having their first cataract surgery compared with those whose cataract surgery was delayed.

March 5, 2020, CLEVELAND: Cleveland Clinic researchers have identified a gut microbe generated byproduct - phenylacetylglutamine (PAG) - that is linked to development of cardiovascular disease, including heart attack, stroke and death. The study was published in Cell today.

Psychologists at the University of Bath, King's College London, and Cardiff have found that a common test used by doctors and researchers to measure autistic personality traits lacks reliability and might not be capturing the right signs of autism.

This means that research including scores from this test may lack validity and raises new questions about its use for screening for autism in the general population.

Researchers at the National Institutes of Health and the University of Wisconsin have demonstrated that using artificial intelligence to analyze CT scans can produce more accurate risk assessment for major cardiovascular events than current, standard methods such as the Framingham risk score (FRS) and body-mass index (BMI).

Boston, Mass. - Commonly known as the breast cancer genes, the BRCA gene family plays a role in repairing damaged DNA. Inherited mutations in the genes BRCA1 or BRCA2 raise the risk of developing breast, ovarian, prostate and other cancers. Led by clinician-researchers at Beth Israel Deaconess Medical Center (BIDMC), a first-of-its-kind study provided new evidence about the optimal way to treat patients who carry BRCA mutations - also known as BRCA carriers - who have been diagnosed with breast cancer.

New Haven, Conn. -- People can carry hazardous compounds from cigarette smoke that cling to their bodies and clothes and then release those compounds into non-smoking environments -- exposing people nearby to cigarettes' adverse effects, a new study shows.

BALTIMORE, MD - March 4, 2020 - Using a combination of magnetic resonance imaging (MRI) to target and sample suspicious prostate tissue along with a standard prostate biopsy is significantly more likely to detect the most aggressive prostate cancers than standard biopsy alone. This finding, published today in the New England Journal of Medicine, could allow a higher percentage of prostate cancer patients to avoid unnecessary treatment for slow-growing prostate cancers that are not likely to spread.

An artificial intelligence (AI) device that has been fast-tracked for approval by the Food and Drug Administration may help identify newborns at risk for aggressive posterior retinopathy of prematurity (AP-ROP). AP-ROP is the most severe form of ROP and can be difficult to diagnose in time to save vision. The findings of the National Eye Institute-funded study published online February 7 in Ophthalmology.

TUCSON, Ariz. – Imagine taking a pill to control your pain and, instead, the medication actually increases the pain you feel. That may be the situation for patients who take opioids, but even more so for women, according to groundbreaking research by investigators at the University of Arizona College of Medicine – Tucson in the Department of Pharmacology.

AURORA, Colo. (March 4, 2020)- Newly published research by a CU School of Medicine faculty member and colleagues identifies multiple ways that health care providers and organizations can improve the quality of care provided to trafficked children.

Karen Albright, PhD, associate professor of medicine at the University of Colorado School of Medicine, has edited a special issue of Child Abuse & Neglect, a journal published by the International Society on the Prevention of Child Abuse and Neglect.