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April 16, 2020 - Bars and nightclubs are a promising site for efforts to increase awareness of the risk of opioid overdose due to fentanyl-laced cocaine, suggests a study in the Journal of Public Health Management and Practice (JPHMP). The journal is published in the Lippincott portfolio by Wolters Kluwer.
At the Japanese High-energy Accelerator Research Organization, KEK, in Tsukuba, about 50 kilometers north of Tokyo, the Belle II experiment has been in operation for about one year now. An international team of researchers also from Karlsruhe Institute of Technology (KIT) is searching for exotic particles that are to enhance our understanding of dark matter in the universe. For one of these particles, the so-called Z' boson, mass and coupling strengths have now been limited with previously unattainable accuracy.
STRASBURG, PA- A new study summarizes more than 30 years of clinical experience and describes the clinical course of 28 individuals homozygous for damaging mutations in the UGT1A1 gene who were born between 1984 and 2015 with Crigler-Najjar syndrome. This morbid and life-threatening disorder is characterized by high levels of toxic bilirubin in the blood which can lead to irreversible brain damage or death.
New research from entomologists at UC Davis clears a potential obstacle to using CRISPR-Cas9 "gene drive" technology to control mosquito-borne diseases such as malaria, dengue fever, yellow fever and Zika.
The idea is to create genetically engineered mosquitoes (GEM) that either fail to reproduce, reducing the mosquito population, or that resist carrying viruses and parasites that cause disease. These mosquitoes would be created in a lab and released to interbreed with wild mosquitoes.
PHILADELPHIA - A blood test may be able to detect the most common form of pancreatic cancer while it is still in its early stages while also helping doctors accurately stage a patient's disease and guide them to the appropriate treatment. A multidisciplinary study from the University of Pennsylvania found the test - known as a liquid biopsy - was more accurate at detecting disease in a blinded study than any other known biomarker alone, and was also more accurate at staging disease than imaging is capable of alone.
Coronary artery disease is the most common type of heart disease, according to the Centers for Disease Control and Prevention. About 18.2 million adults in the United States have coronary artery disease.
CT and MRI are established methods for noninvasive cardiac imaging and evaluation of coronary artery disease. CT is particularly useful for high-resolution images of the coronary anatomy, while cardiac MRI can provide information on blood supply to the heart muscle without exposing patients to ionizing radiation.
What The Viewpoint Says: The importance of recognizing and directly addressing the challenges created by COVID-19 era physical distancing in the care of older adults is addressed.
Authors: Michael A. Steinman, M.D., of the University of California, San Francisco, and the San Francisco VA Medical Center, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamainternmed.2020.1661)
The antiviral drug, baloxavir (tradename Xofluza), is the first treatment for influenza with a new mode of "action" to be licensed in nearly 20 years. It was approved in Australia in February 2020 by the Therapeutic Goods Administration (TGA) and has been used to treat influenza in Japan, the USA, and several other countries since 2018.
Preeclampsia is the leading cause of death and disability, for both mothers and babies, killing approximately 76,000 mothers and 500,000 babies globally every year. Despite this, the only cure at present is to deliver the placenta and the baby, with the potential for long term complications.
In recent years stem cell therapies have been investigated in animal models. A review article published in Current Hypertension Reports investigates mesenchymal stem/stromal cells (MSCs) as a potential new treatment for preeclampsia.
An international research team, led by scientists from Mater Research - The University of Queensland, have discovered they can overcome chemotherapy resistance in an ovarian cancer subtype by using low doses of a drug which slows cell growth.
Principal Investigator, Professor John Hooper and his team based at the Translational Research Institute (TRI) in Brisbane, Australia, collaborated with researchers from the Queensland University of Technology (QUT) and the Mayo Clinic in the United States of America.
WASHINGTON -- The Society for Cardiovascular Angiography and Interventions (SCAI) has released a position statement on adult congenital cardiac interventional training, competencies and organizational recommendations. The paper was published online in SCAI's official journal Catheterization and Cardiovascular Interventions and addresses the rapidly growing field of catheter-based interventions in adults with congenital heart disease.
Aspirin is associated with a reduction in the risk of developing several cancers of the digestive tract, including some that are almost invariably fatal, such as pancreatic and liver cancers.
The largest and most comprehensive analysis to date of the link between aspirin and digestive tract cancers, published in the leading cancer journal Annals of Oncology [1] today (Thursday), found reductions in the risk of these cancers of between 22% and 38%.
Obesity increases the risk of developing type 2 diabetes by at least 6 times, regardless of genetic predisposition to the disease, concludes research published in Diabetologia (the journal of the European Association for the Study of Diabetes [EASD]). The study is by Dr Theresia Schnurr and Hermina Jakupovi?, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark, and colleagues.
St. Jude Children's Research Hospital scientists have identified previously unknown functions of the enigmatic enzyme caspase-6. The findings show that caspase-6 is a key regulator of innate immunity, inflammasome activation and host defense. Modulation of caspase-6 could be beneficial for treating viral diseases like influenza and other inflammatory diseases including cancer. The work appears as an advance online publication today in Cell.
WASHINGTON -- Mosquito-transmitted diseases such as malaria, dengue and yellow fever are responsible for hundreds of thousands of deaths every year, according to the World Health Organization (WHO). A new low-cost imaging system could make it easier to track mosquito species that carry disease, enabling a more timely and targeted response.