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Melbourne researchers have identified mechanisms leading to the functional deterioration of the immune system in response to severe viral infections, such as HIV or COVID-19.
It is widely known that severe viral infections and cancer cause impairments to the immune system, including to T cells, a process called immune 'exhaustion'.
Overcoming immune exhaustion is a major goal for the development of new therapies for cancer or severe viral infections.
When cancer metastasizes and spreads throughout the body, it can severely change the prognosis of the disease. It is estimated that metastasis is responsible for 90 percent of cancer deaths.
University of Chicago Medicine investigators have found a new way to slow the metastasis of colon cancer: by treating it with a small molecule that essentially locks up cancer cells' ability to change shape and move throughout the body.
Inflammatory bowel disease (IBD) is a group of intestinal disorders affecting an estimated six to eight million people worldwide. Although there are many treatments for IBD, a number of patients fail to respond long-term, leaving those afflicted with a host of chronic issues, from abdominal pain and cramping to frequent, bloody stools.
August 24, 2020 - Automated patient monitoring systems (PMSs) have been designed to reduce delays in diagnosis of sepsis in hospitalized patients. But so far, studies evaluating these systems have shown inconsistent effects on mortality rates and other patient outcomes, according to an evidence review in a special September supplement to the
New Haven, Conn. -- Less is sometimes more when treating heart patients who go into shock after a heart attack.
ROCHESTER, Minn. - A study of search engine queries addressed the question of whether online searches for chest pain symptoms correlated to reports of fewer people going to the emergency department with acute heart problems during the COVID-19 pandemic.
A new study conducted by a team of researchers, including University of Colorado Denver Business School associate professor Jiban Khuntia, PhD, found while social distancing is an effective preventative measure in the fight against COVID-19, there are significant variations being observed in how and why individuals follow the restrictions.
[Vienna, 24 August 2020] With the first COVID-19 epidemic peak behind them, many countries explained the decrease of infection numbers through non-pharmaceutical interventions. Phrases like "social distancing" and "flatten the curve" have become part of common vocabulary. Yet some explanations fell short: How could one explain the linear rise of infection curves, which many countries display after the first peak, in contrast to the S-shaped curves, expected from epidemiological models?
The mass media's coverage of the pandemic health crisis carries an important responsibility to offer balanced messaging about COVID-19 and public behaviour, Flinders University public health researchers says.
While freely available, trustworthy news is vital - in particular when conveying personal risk and government mandated guidelines - the Flinders University research warns of less favourable issues such as inciting panic or causing stigmatisation in the community by laying blame on certain groups or organisations.
Aerobic exercise clearly benefits young adults with major depression, and a Rutgers-led study suggests it may be possible to predict those who would benefit from behavioral therapy with exercise.
SILVER SPRING, Md.--New research shows that an intensive lifestyle intervention (ILI) aimed at weight loss lowered incidence of obesity-related cancers in adults with overweight or obesity and type 2 diabetes, according to a study published online in Obesity, the flagship journal of The Obesity Society. This study is the only randomized clinical trial that has examined long-term cancer outcomes in an ILI focused on weight loss.
DALLAS, Aug. 24, 2020 -- None of the 41 most common high blood pressure medications increased the risk of depression, while nine medications appeared to lower it, according to a study from Denmark, published today in Hypertension, an American Heart Association journal.
Depression is common among patients with high blood pressure (also called hypertension), heart disease and stroke, and this is the first study to systematically investigate whether individual blood pressure medications might influence the risk of developing depression.
Sophia Antipolis, France - 24 Aug 2020: Deep chest compressions can crack ribs, but they reduce brain damage during cardiac arrest, reports a study presented today at ESC Congress 2020.1
Study author Dr. Irene Marco Clement of University Hospital La Paz, Madrid, Spain said: "Deep chest compressions improve blood flow to the brain, improving survival and brain function."
Philadelphia, August 24, 2020--Despite intensive treatment, high-risk solid tumors like neuroblastoma, Ewing sarcoma, and rhabdomyosarcoma are challenging to cure because the disease in those high-risk patients does not respond to therapy. Conventional chemotherapy given by vein or by mouth delivers only a small amount of the drugs to the tumor, which not only renders the treatment ineffective but also leads to drug resistance and severe side effects, including diarrhea, bone marrow suppression and secondary malignancies.
Nonprescribed fentanyl and stimulants were the primary contributors to overdose mortality, while few people had prescribed opioids in their systems, according to new toxicology research in CMAJ (Canadian Medical Association Journal).