Ospemifene (tradename: Senshio) is approved for the treatment of moderate to severe symptomatic vulvovaginal atrophy (VVA) in post-menopausal women who are not candidates for local vaginal oestrogen therapy. The drug has been on the market in Germany since May 2016. In an early benefit assessment, the German Institute for Quality and Efficiency in Health Care (IQWiG) has now examined whether it has advantages or disadvantages in comparison with the appropriate comparator therapy.
Body
Many cancers only become a mortal danger if they form metastases elsewhere in the body. Such secondary tumours are formed when individual cells break away from the main tumour and travel through the bloodstream to distant areas of the body. To do so, they have to pass through the walls of small blood vessels. Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim and Goethe University Frankfurt have now shown that tumour cells kill specific cells in the vascular wall.
For the first time, researchers have revealed the nanostructure of the mesoporous magnesium carbonate Upsalite® and pore size control was achieved without organic templates or swelling agents. By controlling the pore structure of the material the amorphous phase stabilisation exerted on poorly soluble drug compounds can be tuned and the drug delivery rate can be tailored.
Future Science Group (FSG) today announced the publication of a new article in Future Science OA examining the effects of diabetes on hospitalization risk, chances of multiple admissions, and length of hospitalization stay, for patients suffering from solid-organ malignancies such as breast, colorectal, lung and pancreas, among others.
The BioScience Talks podcast features discussions of topical issues related to the biological sciences.
Cold seeps are places where hydrocarbons, mostly methane, emanate from the sea floor. Unlike the hydrothermal vents, the fluids and bubbles are no hotter than the surrounding seawater, thus the name.
But like the hydrothermal vents, cold seeps can support high densities of specialized life forms through a process called chemosynthesis.
These seeps can dramatically influence many aspects of the overall seabed community, even in the frigid and dark Arctic Ocean, new study featured in Marine Ecology Progress Series shows.
Toronto, August 10, 2016 - Could a small drop in the alcohol content of beer or other drinks reduce the harmful effects of alcohol in society at large?
A new review in Lancet Gastroenterology & Hepatology, which explores the evidence, suggests this approach may be worth pursuing. Alcohol accounts for significant death and disability worldwide. Among those aged 20-39, nearly one-quarter of deaths can be attributed to alcohol, according to the World Health Organization.
Despite the United Nations Millennium Development Goal of a 75 percent reduction in maternal deaths by 2015, the estimated maternal mortality rate for 48 U.S. states and the District of Columbia actually increased by 26.6 percent from 2000 to 2014, according to a new study co-authored by Boston University School of Public Health (BUSPH) researchers.
Pancreatic cancer cells avert starvation in dense tumors by ordering nearby support cells to supply them with an alternative source of nutrition. This is the finding of a study in cancer cells and mice published August 10 in Nature. The study was led by researchers from NYU Langone Medical Center, the Dana Farber Cancer Institute at Harvard, and the University of Michigan Medical School.
(Boston)-- A new study, based on data from the Framingham Heart Study (FHS) suggests a simple test of physical functioning may be able to help physicians identify individuals who are at a higher risk for developing Alzheimer's disease and stroke.
These findings, which appear in the Journal of Alzheimer's Disease, provide hope that there are easy-to-test clinical markers that will help physicians identify individuals who are at increased risk for common age-related neurological diseases.
Ripped pants or a torn shirt usually means a trip to the tailor or a garbage can is in one's future. But scientists could be closing in on a new solution. They report in the journal ACS Applied Materials & Interfaces a fabric coating made of squid proteins that allows rips in cotton, linen and wool to "heal" themselves.
During the annual top conference of the Special Interest Group for Computer Graphics (SIGGRAPH) of the Association for Computing Machinery (ACM), which took place in Anaheim, USA, IST Austria Professor Bernd Bickel and his group present an algorithm that allows improved technical modelling of planar-rod structures consisting of interlocking wires. After designing an aesthetically pleasing structure, e.g. a car or a duck, the contours of the objects are re-calculated with the new algorithm.
Hot dogs are the perfect summer fare. But knowing for sure what you're getting inside a bun can be difficult. Now scientists have devised a method that could help prevent frankfurter fraud, which is especially important for those who can't eat certain types of meats. They report their approach in ACS' Journal of Agricultural and Food Chemistry.
Even brief exposures of the eggs of Atlantic haddock to low concentrations of dispersed crude oil can cause severe and usually deadly deformities in developing fish, an international research team has found.
The findings indicate that oil spills at high latitudes could have serious impacts on some of the world's most important fisheries, including those for haddock, cod and pollock.
Olympics officials already contending with the illegal use of steroids among athletes are now being proactive about a potential new trend in performance enhancement: gene doping. Although tests for this type of cheating won't be performed until after the Games, the results could still mean bad news for implicated athletes. An article in Chemical & Engineering News (C&EN), the weekly newsmagazine of the American Chemical Society, explores how experts are planning to catch cheating athletes.